Flavonoids as potential anti-platelet aggregation agents: from biochemistry to health promoting abilities

Sharifi‐Rad, Javad; Quispe, Cristina; Shaheen, Shabnum; Haouari, Mohammed El; Azzini, Elena; Butnariu, Monica; Sărac, Ioan; Pentea, Marius; Ramírez‐Alarcón, Karina; Martorell, Miquel; Kumar, Manoj; Docea, Anca Oana; Cruz‐Martins, Natália; Calina, Daniela

doi:10.1080/10408398.2021.1924612

Cited by 41 publications

(21 citation statements)

References 105 publications

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“…Active compounds or secondary metabolites are produced in plants as a byproduct of various metabolic reactions; although they do not play a primary role in plant reactions, they are important in many plant defence mechanisms and are also known for their biological or therapeutic activities [ 24 – 26 ]. The most important class of secondary metabolites are phenols, flavonoids, terpenoids, alkaloids, saponins, and glycosides [ 27 – 29 ].…”

Section: Bioactive Compoundsmentioning

confidence: 99%

Nutraceutical Profiling, Bioactive Composition, and Biological Applications of Lepidium sativum L.

Painuli

Quispe

Herrera‐Bravo

et al. 2022

Oxidative Medicine and Cellular Longevity

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The roots, leaves, and seeds of Lepidium sativum L., popularly known as Garden cress in different regions, have high economic importance; although, the crop is particularly cultivated for the seeds. In traditional medicine, this plant has been reported to possess various biological activities. This review is aimed at providing updated and critical scientific information about the traditional, nutritional, phytochemical, and biological activities of L. sativum. In addition, the geographic distribution is also reviewed. The comprehensive literature search was carried out with the help of different search engines PubMed, Web of Science, and Science Direct. This review highlighted the importance of L. sativum as an edible herb that possesses a wide range of therapeutic properties along with high nutritional values. Preclinical studies (in vitro and in vivo) displayed anticancer, hepatoprotective, antidiabetic, hypoglycemic, antioxidant, antimicrobial, gastrointestinal, and fracture/bone healing activities of L. sativum and support the clinical importance of plant-derived bioactive compounds for the treatment of different diseases. Screening of literature revealed that L. sativum species and their bioactive compounds may be a significant source for new drug compounds and also could be used against malnutrition. Further clinical trials are needed to effectively assess the actual potential of the species and its bioactive compounds.

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Section: Bioactive Compoundsmentioning

confidence: 99%

Nutraceutical Profiling, Bioactive Composition, and Biological Applications of Lepidium sativum L.

Painuli

Quispe

Herrera‐Bravo

et al. 2022

Oxidative Medicine and Cellular Longevity

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“…It is grounded by scientists that the human brain use 20% of the body's daily intake of O 2 . The human brain has a significant amount of polyunsaturated fatty acids (Sharifi-Rad et al, 2021b). These along with transition metal ions and poor antioxidant enzymes makes the organ vulnerable in front of free radicals (Uttara et al, 2009;Buga et al, 2019;Aloizou et al, 2021).…”

Section: Quercetin Against Oxidative Stressmentioning

confidence: 99%

Neuropharmacological Effects of Quercetin: A Literature-Based Review

et al. 2021

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Quercetin (QUR) is a natural bioactive flavonoid that has been lately very studied for its beneficial properties in many pathologies. Its neuroprotective effects have been demonstrated in many in vitro studies, as well as in vivo animal experiments and human trials. QUR protects the organism against neurotoxic chemicals and also can prevent the evolution and development of neuronal injury and neurodegeneration. The present work aimed to summarize the literature about the neuroprotective effect of QUR using known database sources. Besides, this review focuses on the assessment of the potential utilization of QUR as a complementary or alternative medicine for preventing and treating neurodegenerative diseases. An up-to-date search was conducted in PubMed, Science Direct and Google Scholar for published work dealing with the neuroprotective effects of QUR against neurotoxic chemicals or in neuronal injury, and in the treatment of neurodegenerative diseases. Findings suggest that QUR possess neuropharmacological protective effects in neurodegenerative brain disorders such as Alzheimer’s disease, Amyloid β peptide, Parkinson’s disease, Huntington's disease, multiple sclerosis, and amyotrophic lateral sclerosis. In summary, this review emphasizes the neuroprotective effects of QUR and its advantages in being used in complementary medicine for the prevention and treatment o of different neurodegenerative diseases.

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“…Apigenin is a natural flavonoid that exists in multiple plants, vegetables, fruits, spices, and Chinese herbal medicines (Shankar et al, 2017;Sharma et al, 2019). A bunch of research studies indicated that apigenin exerts anti-inflammatory (Wang and Huang, 2013), antioxidant (Yang et al, 2020), anticancer (Guedj et al, 2020), and antiplatelet aggregation effect (Sharifi-Rad et al, 2021) in various diseases, such as neurodegenerative diseases and epilepsy, which can alleviate pathogenesis and symptoms of them (Sang et al, 2020;Sharma et al, 2020). In recent studies, apigenin showed the ability to induce autophagy and improve autophagic flux in various tissues, such as human skin, cartilage, heart, and retina (Bridgeman et al, 2016;Cho et al, 2019;Zhang et al, 2020b).…”

Section: Introductionmentioning

confidence: 99%

Apigenin Alleviates Intervertebral Disc Degeneration via Restoring Autophagy Flux in Nucleus Pulposus Cells

Xie

Shi

Zuo-xi

et al. 2022

Front. Cell Dev. Biol.

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Oxidative stress–induced apoptosis and senescence of nucleus pulposus (NP) cells play a crucial role in the progression of intervertebral disc degeneration (IVDD). Accumulation of studies has shown that activated autophagy and enhanced autophagic flux can alleviate IVDD. In this study, we explored the effects of apigenin on IVDD in vitro and in vivo. Apigenin was found to inhibit tert-butyl hydroperoxide (TBHP)–induced apoptosis, senescence, and ECM degradation in NP cells. In addition, apigenin treatment can restore the autophagic flux blockage caused by TBHP. Mechanistically, we found that TBHP may induce autophagosome and lysosome fusion interruption and lysosomal dysfunction, while apigenin alleviates these phenomena by promoting the nuclear translocation of TFEB via the AMPK/mTOR signaling pathway. Furthermore, apigenin also exerts a protective effect against the progression of IVDD in the puncture-induced rat model. Taken together, these findings indicate that apigenin protects NP cells against TBHP-induced apoptosis, senescence, and ECM degradation via restoration of autophagic flux in vitro, and it also ameliorates IVDD progression in rats in vivo, demonstrating its potential for serving as an effective therapeutic agent for IVDD.

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Flavonoids as potential anti-platelet aggregation agents: from biochemistry to health promoting abilities

Cited by 41 publications

References 105 publications

Nutraceutical Profiling, Bioactive Composition, and Biological Applications of Lepidium sativum L.

Nutraceutical Profiling, Bioactive Composition, and Biological Applications of Lepidium sativum L.

Neuropharmacological Effects of Quercetin: A Literature-Based Review

Apigenin Alleviates Intervertebral Disc Degeneration via Restoring Autophagy Flux in Nucleus Pulposus Cells

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