Nutraceutical Profiling, Bioactive Composition, and Biological Applications of Lepidium sativum L.

Painuli, Sakshi; Quispe, Cristina; Herrera‐Bravo, Jesús; Semwal, Prabhakar; Martorell, Miquel; Almarhoon, Zainab M.; Seilkhan, Ainur; Ydyrys, Alibek; Sharifi‐Rad, Javad; Alshehri, Mohammed M.; Daştan, Sevgi Durna; Taheri, Yasaman; Calina, Daniela; Cho, William C.

doi:10.1155/2022/2910411

Cited by 40 publications

(37 citation statements)

References 106 publications

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“…Obesity is also associated with liver disease. Over time, liver damage results in scarring (cirrhosis), which can lead to liver failure, a life-threatening condition [ 145 , 146 ]. Under this topic, Xie et al [ 147 ] reported on the impact of diosgenin on transforming growth factor (TGF)- β 1-induced hepatic stellate cells and its mechanism of action for antifibrotic effects.…”

Section: Pharmacological Properties Of Diosgenin: Underlying Molecula...mentioning

confidence: 99%

Diosgenin: An Updated Pharmacological Review and Therapeutic Perspectives

Semwal

Painuli

Abu-Izneid

et al. 2022

Oxidative Medicine and Cellular Longevity

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Plants including Rhizoma polgonati, Smilax china, and Trigonella foenum-graecum contain a lot of diosgenin, a steroidal sapogenin. This bioactive phytochemical has shown high potential and interest in the treatment of various disorders such as cancer, diabetes, arthritis, asthma, and cardiovascular disease, in addition to being an important starting material for the preparation of several steroidal drugs in the pharmaceutical industry. This review aims to provide an overview of the in vitro, in vivo, and clinical studies reporting the diosgenin’s pharmacological effects and to discuss the safety issues. Preclinical studies have shown promising effects on cancer, neuroprotection, atherosclerosis, asthma, bone health, and other pathologies. Clinical investigations have demonstrated diosgenin’s nontoxic nature and promising benefits on cognitive function and menopause. However, further well-designed clinical trials are needed to address the other effects seen in preclinical studies, as well as a better knowledge of the diosgenin’s safety profile.

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Section: Pharmacological Properties Of Diosgenin: Underlying Molecula...mentioning

confidence: 99%

Diosgenin: An Updated Pharmacological Review and Therapeutic Perspectives

Semwal

Painuli

Abu-Izneid

et al. 2022

Oxidative Medicine and Cellular Longevity

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“…The synergistic combination of arctigenin and quercetin has been studied in two prostate cancer cell lines, LAPC-4 and LNCaP. The results indicate that this combination can inhibit the expression of oncogenic miRs miR21, miR-19b and miR-148a in LAPC-4 and miR21 and miR-148a in LNCaP cell line way more effectively than quercetin alone [162][163][164].…”

Section: Synergistic Mechanisms Of Quercetin With Anticancer Drugs An...mentioning

confidence: 99%

Potential mechanisms of quercetin in cancer prevention: focus on cellular and molecular targets

et al. 2022

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Over the past few years, the cancer-related disease has had a high mortality rate and incidence worldwide, despite clinical advances in cancer treatment. The drugs used for cancer therapy, have high side effects in addition to the high cost. Subsequently, to reduce these side effects, many studies have suggested the use of natural bioactive compounds. Among these, which have recently attracted the attention of many researchers, quercetin has such properties. Quercetin, a plant flavonoid found in fresh fruits, vegetables and citrus fruits, has anti-cancer properties by inhibiting tumor proliferation, invasion, and tumor metastasis. Several studies have demonstrated the anti-cancer mechanism of quercetin, and these mechanisms are controlled through several signalling pathways within the cancer cell. Pathways involved in this process include apoptotic, p53, NF-κB, MAPK, JAK/STAT, PI3K/AKT, and Wnt/β-catenin pathways. In addition to regulating these pathways, quercetin controls the activity of oncogenic and tumor suppressor ncRNAs. Therefore, in this comprehensive review, we summarized the regulation of these signalling pathways by quercetin. The modulatory role of quercetin in the expression of various miRNAs has also been discussed. Understanding the basic anti-cancer mechanisms of these herbal compounds can help prevent and manage many types of cancer.

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“…Oxidative stress is triggered by an imbalance between the amount of reactive oxygen species/free radicals, which cause harmful effects, and the body’s natural antioxidant defense mechanisms [ 125 , 126 ]. In recent decades, research has focused on finding natural antioxidant substances that can neutralize the negative potential of free radicals [ 127 , 128 , 129 ].…”

Section: Other Pharmacological Propertiesmentioning

confidence: 99%

Anticancer Potential and Other Pharmacological Properties of Prunus armeniaca L.: An Updated Overview

Kitić

Miladinović

Randjelović

et al. 2022

Plants

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Prunus armeniaca L. (Rosaceae)-syn. Amygdalus armeniaca (L.) Dumort., Armeniaca armeniaca (L.) Huth, Armeniaca vulgaris Lam is commonly known as the apricot tree. The plant is thought to originate from the northern, north-western, and north-eastern provinces of China, although some data show that it may also come from Korea or Japan. The apricot fruit is used medicinally to treat a variety of ailments, including use as an antipyretic, antiseptic, anti-inflammatory, emetic, and ophthalmic remedy. The Chinese and Korean pharmacopeias describe the apricot seed as an herbal medicinal product. Various parts of the apricot plant are used worldwide for their anticancer properties, either as a primary remedy in traditional medicine or as a complementary or alternative medicine. The purpose of this review was to provide comprehensive and up-to-date information on ethnobotanical data, bioactive phytochemicals, anticancer potential, pharmacological applications, and toxicology of the genus Prunus armeniaca, thus providing new perspectives on future research directions. Included data were obtained from online databases such as PubMed/Medline, Google Scholar, Science direct, and Wiley Online Library. Multiple anticancer mechanisms have been identified in in vitro and in vivo studies, the most important mechanisms being apoptosis, antiproliferation, and cytotoxicity. The anticancer properties are probably mediated by the contained bioactive compounds, which can activate various anticancer mechanisms and signaling pathways such as tumor suppressor proteins that reduce the proliferation of tumor cells. Other pharmacological properties resulting from the analysis of experimental studies include neuroprotective, cardioprotective, antioxidant, immunostimulatory, antihyperlipidemic, antibacterial, and antifungal effects. In addition, data were provided on the toxicity of amygdalin, a compound found in apricot kernel seeds, which limits the long-term use of complementary/alternative products derived from P. armeniaca. This updated review showed that bioactive compounds derived from P. armeniaca are promising compounds for future research due to their important pharmacological properties, especially anticancer. A detailed analysis of the chemical structure of these compounds and their cytotoxicity should be carried out in future research. In addition, translational pharmacological studies are required for the correct determination of pharmacologically active doses in humans.

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Nutraceutical Profiling, Bioactive Composition, and Biological Applications of Lepidium sativum L.

Cited by 40 publications

References 106 publications

Diosgenin: An Updated Pharmacological Review and Therapeutic Perspectives

Diosgenin: An Updated Pharmacological Review and Therapeutic Perspectives

Potential mechanisms of quercetin in cancer prevention: focus on cellular and molecular targets

Anticancer Potential and Other Pharmacological Properties of Prunus armeniaca L.: An Updated Overview

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