Correction to: The effect of vitamin D and magnesium supplementation on the mental health status of attention-deficit hyperactive children: a randomized controlled trial

Hemamy, Mostafa; Pahlavani, Naseh; Amanollahi, Alireza; Islam, Sheikh Mohammed Shriful; McVicar, Jenna; Askari, Gholamreza; Malekahmadi, Mahsa

doi:10.1186/s12887-021-02683-3

Cited by 3 publications

(3 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results obtained in this study pointed out the importance of dietary supplementation as a current therapeutic approach in modern risk stratification to several health issues, such as mental health diseases [27,28], diabetes mellitus [29,30], and cardiovascular insufficiency [31,32] or fungal infections [33,34]. This type of dietary intervention appears to be an available approach to the cost associated with prevention, aiming to optimal therapeutic outcomes [35].…”

Section: Figurementioning

confidence: 69%

5-Hydroxitryptophan Dietary Supplementation in Post-Traumatic Stress Syndrome

ŢINCU¹

2022

FARMACIA

View full text Add to dashboard Cite

Major depressive disorder (MDD) is a common psychological long-term consequence of patients that have been treated in intensive care units together with anxiety disorders (AD) and posttraumatic stress disorder (PTSD). This study aimed to investigate the effect of 5-hydroxytryptophan administration on serotonin levels in critically ill patients and the prevalence of psychiatric disorders in our patients. A randomized controlled trial was conducted in the Anaesthesia and Intensive Care Unit, Clinical Emergency Hospital Bucharest, Romania, on patients admitted for severe non-surgical illness aged from 18 to 55 years. Thirty subjects were recruited and randomized through sealed envelopes with a concealed 1:1 allocation to either treated or control group: Group 1 -placebo (control group) and Group 2 (5-TRP group) -treated with 300 mg of 5-hydroxytryptophan twice daily. After 7 days, Group 2 had higher levels of serum serotonin (230.06 ± 34.96 μg/L) in comparison to the control group (181.20 ± 38.87 μg/L; p < 0.001). The incidence of depression was 24.49% in Group 2 and 42.17% in Group 1 (p < 0.005) after 30 days of observation. Our results suggest that due to his role as an immediate precursor, 5-hydroxytryptophan increases the plasma level of serotonin, with a beneficial effect on anxiety and depression of the treated patients. RezumatTulburarea depresivă majoră (MDD) este o consecință psihologică frecventă pe termen lung a pacienților care au necesitat suport vital în unitățile de terapie intensivă însoțită frecvent de tulburări de anxietate și de tulburarea de stres posttraumatic (PTSD). Studiul de față și-a propus să investigheze efectul administrării de 5-hidroxitriptofan asupra nivelului serotoninei la pacienții în stare critică precum și prevalența tulburărilor psihice la pacienții înrolați. Am realizat un studiu controlat randomizat în cadrul Secției de Anestezie și Terapie Intensivă-Toxicologie, Spitalul Clinic de Urgență București, România cu înrolarea pacienților admiși pentru afecțiuni severe non-chirurgicale, având vârsta cuprinsă între 18 și 55 de ani. Treizeci de participanți au fost recrutați și randomizați prin plicuri sigilate cu o alocare ascunsă 1: 1 fie la grupul tratat, fie la grupul de control: Grupul 1 -placebo (grupul de control) și Grupul 2 (grupul 5-TRP) -tratat cu 300 mg de 5-hidroxitriptofan de două ori zilnic. După 7 zile, grupul 2 a avut niveluri serice de serotonină mai mari (230,06 ± 34,96 μg/L) comparativ cu grupul martor (181,20 ± 38,87 μg/L; p < 0,001). Incidența depresiei a fost de 24,49% în grupul 2 și de 42,17% în grupul 1 (p < 0,005) după 30 de zile de observație. Rezultatele noastre sugerează faptul că, datorită rolului său de precursor imediat, 5-hidroxitriptofanul crește nivelul plasmatic al serotoninei, cu efect benefic asupra anxietății și depresiei pacienților tratați.

show abstract

Section: Figurementioning

confidence: 69%

5-Hydroxitryptophan Dietary Supplementation in Post-Traumatic Stress Syndrome

ŢINCU¹

2022

FARMACIA

View full text Add to dashboard Cite

show abstract

“…Magnesium is vital for absorption of other macronutrients as calcium by converting vitamin D to its active form, which is indispensable for the development and growth of bones in infants and children ( Vormann, 2003 ). Hemamy et al showed that vitamin D (50,000 IU/week) and magnesium (6 mg/kg/day) co-supplementation for a duration of 8-weeks could improve the behavioral function and mental health of children with Attention-Deficit Hyperactivity Disorder (ADHD) ( Hemamy et al, 2021 ). Another interesting finding showed that that higher plasma magnesium and calcium concentrations were negatively related to blood pressure in children aged 6–9 years ( Chen et al, 2021 ).…”

Section: Resultsmentioning

confidence: 99%

Dietary macrominerals: Updated review of their role and orchestration in human nutrition throughout the life cycle with sex differences

Farag

Abib

Qin

et al. 2023

Current Research in Food Science

View full text Add to dashboard Cite

“…The evidence on the improvement of ADHD-related cognitive symptoms with Vit-D supplementation (Elshorbagy et al, 2018) has supported the hypothesis of Vit-D deficiency-related ADHD-resembling cognitive and behavioral traits in CD. In the most recent double-blind placebo-controlled randomized study, Vit-D and magnesium supplementation for 8 weeks in 66 children with ADHD was associated with improvement in either the total or subscores of the SDQ (Hemamy et al, 2021). However, in the present study, the alteration in Vit-D levels of CD did not correlate with the attention-deficit subscores of either SDQc or AT.…”

Section: Discussionmentioning

confidence: 99%

A Clinical Investigation on ADHD-Traits in Childhood Celiac Disease

Efe

Tok

2023

J Atten Disord

View full text Add to dashboard Cite

Objective: There are no definitive results about either the presence of exact comorbidity between celiac disease (CD) and attention-deficit/hyperactivity disorders (ADHD) or etiology. We intend to screen ADHD-related cognitive and behavioral traits in children with biopsy-proven CD and investigate the possible association of these traits with certain vitamin levels, body-mass index, and gluten-free diet (GFD) compliance. Method: A total of 85 children with biopsy-proven CD (the ages of 8–18 years) were compared with age and sex-matched 72 healthy controls in terms of demographics, psychiatric symptoms, certain vitamin levels, and anthropometric measurements. Results: ADHD-like cognitive issues, such as inattention and learning difficulties, as well as psychosomatic symptoms and poor prosocial behavior, were all associated with GFD noncompliance in childhood CD. Conclusion: Untreated CD may predispose to ADHD-resembling symptoms. Physicians should be aware of the probability of ADHD misdiagnosing due to ADHD-resembling cognitive and behavioral traits in untreated CD.

show abstract

Correction to: The effect of vitamin D and magnesium supplementation on the mental health status of attention-deficit hyperactive children: a randomized controlled trial

Cited by 3 publications

References 1 publication

5-Hydroxitryptophan Dietary Supplementation in Post-Traumatic Stress Syndrome

5-Hydroxitryptophan Dietary Supplementation in Post-Traumatic Stress Syndrome

Dietary macrominerals: Updated review of their role and orchestration in human nutrition throughout the life cycle with sex differences

A Clinical Investigation on ADHD-Traits in Childhood Celiac Disease

Contact Info

Product

Resources

About