Magnetic microspheres based on pectin coated by chitosan towards smart drug release

Lemos, Thalia S.A.; Souza, Jaqueline F. de; Fajardo, André R.

doi:10.1016/j.carbpol.2021.118013

Cited by 49 publications

(20 citation statements)

References 56 publications

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“…The release of drug-eluted chitosan microspheres exhibited a two-stage profile: an initial burst release in the first several days and sustained release in the following stage. As shown in Figure 3 , the 5-FU and CDDP showed a burst release at the beginning, and completed release around 10 days ( Figure 3 A,B); this is a common phenomenon of drug-loaded microspheres [ 42 ]. The initial rapid release can be attributed to the diffusion of drugs adhered to the surface of microspheres.…”

Section: Resultsmentioning

confidence: 99%

Injectable, Anti-Cancer Drug-Eluted Chitosan Microspheres against Osteosarcoma

Zhao

Tian

Shang

et al. 2022

JFB

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The purpose of this study is to fabricate different anti-cancer drug-eluted chitosan microspheres for combination therapy of osteosarcoma. In this study, electrospray in combination with ground liquid nitrogen was utilized to manufacture the microspheres. The size of obtained chitosan microspheres was uniform, and the average diameter was 532 μm. The model drug release rate and biodegradation rate of chitosan microspheres could be controlled by the glutaraldehyde vapor crosslinking time. Then the 5-fluorouracil (5-FU), paclitaxel (PTX), and Cis-dichlorodiammine-platinum (CDDP) eluted chitosan microspheres were prepared, and two osteosarcoma cell lines, namely, HOS and MG-63, were selected as cell models for in vitro demonstration. We found the 5-FU microspheres, PTX microspheres, and CDDP microspheres could significantly inhibit the growth and migration of both HOS and MG-63 cells. The apoptosis of both cells treated with 5-FU microspheres, PTX microspheres, and CDDP microspheres was significantly increased compared to the counterparts of control and blank groups. The anti-cancer drug-eluted chitosan microspheres show great potential for the treatment of osteosarcoma.

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Section: Resultsmentioning

confidence: 99%

Injectable, Anti-Cancer Drug-Eluted Chitosan Microspheres against Osteosarcoma

Zhao

Tian

Shang

et al. 2022

JFB

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“…The absorbance value of each sample was quantified by spectrophotometer at 430 nm and the concentration of released curcumin from each membrane was calculated based on a curcumin standard curve: A = 0.00706 C i − 0.01427. In order to draw the cumulative release rate‐time curves, the concentration was brought into Equations (3)–(5) to calculate the cumulative release rate ( Q i ) 29

W_{r} goodbreak= 50 goodbreak\times C_{i} goodbreak+ 3 goodbreak\times \sum_{i = 1}^{n} C_{i - 1}

W_{r 0} goodbreak= italicma / ((), a goodbreak+ b)

Q_{i} goodbreak= W_{r} / W_{r 0} goodbreak\times 100 %

where W r is the cumulative release of drugs at the i sampling, μg; C i is the concentration of drugs at the i sampling, μg/mL; Q i is the cumulative release rate of Cur at each time interval; W r0 is the actual content of Cur in each composite membrane, μg; m is the mass of each composite membrane, μg; a/a + b is the ratio of Cur to total polysaccharides in each composite membrane.…”

Section: Methodsmentioning

confidence: 99%

Preparation and properties of triethyl citrate plasticized chitosan‐based membranes for efficient release of curcumin

Wei

Zhang

et al. 2021

J of Applied Polymer Sci

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In order to improve the release efficiency and physical properties of single polysaccharide membranes, two types of curcumin (Cur)‐loaded composite membranes have been successfully prepared through chitosan (CS)/carboxymethyl cellulose (CMC), CS/soluble starch (SS) with triethyl citrate (TEC) as a plasticizer. The structure and properties of the membranes were characterized by infrared spectroscopy, scanning electron microscopy, X‐ray diffraction, and thermogravimetry. The results of mechanical tests and drug release experiments show that TEC changes the intermolecular forces in the membrane matrix, makes the membrane more flexible and increases the cumulative release rate of curcumin. The cumulative release rate of Cur in CS/CMC‐Cur and the CS/SS‐Cur membrane can reach 86.5% and 87.3% at 24 h, respectively. Cur release in CS/CMC‐Cur followed the irregular Fickian diffusion behavior, whereas in CS/SS‐Cur followed the non‐Fickian diffusion behavior. The prepared composite membrane performs good thermal stability, tensile resistance and strong inhibitory effect on Escherichia coli.

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“…To further improve the intestinal-targeted release properties, pH- and magnetism-responsive hydrogel beads were prepared, consisting of composite systems made of magnetic nanoparticles mixed with polymers such as carboxymethylcellulose or pectin, and coated with CS [ 308 , 309 , 310 ]. All of these systems prevented release in the GI tract and showed pH-dependent release profiles of the included model drugs; the application of an external magnetic field can further increase the drug release at the targeted intestinal tract, revealing their potential as multi-responsive delivery systems.…”

Section: Chitosan-based Mucosal Drug Delivery Systemsmentioning

confidence: 99%

Multiple Roles of Chitosan in Mucosal Drug Delivery: An Updated Review

et al. 2022

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Chitosan (CS) is a linear polysaccharide obtained by the deacetylation of chitin, which, after cellulose, is the second biopolymer most abundant in nature, being the primary component of the exoskeleton of crustaceans and insects. Since joining the pharmaceutical field, in the early 1990s, CS attracted great interest, which has constantly increased over the years, due to its several beneficial and favorable features, including large availability, biocompatibility, biodegradability, non-toxicity, simplicity of chemical modifications, mucoadhesion and permeation enhancer power, joined to its capability of forming films, hydrogels and micro- and nanoparticles. Moreover, its cationic character, which renders it unique among biodegradable polymers, is responsible for the ability of CS to strongly interact with different types of molecules and for its intrinsic antimicrobial, anti-inflammatory and hemostatic activities. However, its pH-dependent solubility and susceptibility to ions presence may represent serious drawbacks and require suitable strategies to be overcome. Presently, CS and its derivatives are widely investigated for a great variety of pharmaceutical applications, particularly in drug delivery. Among the alternative routes to overcome the problems related to the classic oral drug administration, the mucosal route is becoming the favorite non-invasive delivery pathway. This review aims to provide an updated overview of the applications of CS and its derivatives in novel formulations intended for different methods of mucosal drug delivery.

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Magnetic microspheres based on pectin coated by chitosan towards smart drug release

Cited by 49 publications

References 56 publications

Injectable, Anti-Cancer Drug-Eluted Chitosan Microspheres against Osteosarcoma

Injectable, Anti-Cancer Drug-Eluted Chitosan Microspheres against Osteosarcoma

Preparation and properties of triethyl citrate plasticized chitosan‐based membranes for efficient release of curcumin

Multiple Roles of Chitosan in Mucosal Drug Delivery: An Updated Review

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