The Efficacy of Platelet-Rich Plasma for Improving Pain and Function in Lateral Epicondylitis: A Systematic Review and Meta-analysis with Risk-of-Bias Assessment

Chen, Xiao T.; Fang, William; Jones, Ian A.; Heckmann, Nathanael; Park, Caron; Vangsness, C. Thomas

doi:10.1016/j.arthro.2021.04.061

Cited by 20 publications

(10 citation statements)

References 78 publications

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“…In another meta-analysis based on 16 studies, Chen et al, found that despite a significant clinical improvement, they were unable to recommend for or against the use of PRP for lateral epicondylitis. This was due to the small number of comparable studies, a lack of quantification of the specific PRP content, considerable heterogeneity between the randomized control trials, and most effect sizes being equivocal within the framework of two estimated MCID values [47]. Another point of view was presented by de Vos et al, in their systematic review based on six studies, in which the authors stated that there was strong evidence that PRP is not effective in treating chronic lateral elbow tendinosis [17].…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of Lateral Elbow Tendinopathy Treatment Depends on the Content of Biologically Active Compounds in Autologous Platelet-Rich Plasma

Dejnek

Moreira

Płaczkowska

et al. 2022

JCM

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Autologous platelet-rich plasma (PRP) injection is an alternative treatment option for patients with lateral elbow tendinopathy. The treatment is supposed to accelerate tissue regeneration by providing high concentrations of growth factors derived from platelets. The aim of the study was to assess the relationship between the content of biologically active compounds in PRP and the clinical effect of the treatment. Thirty patients with lateral elbow tendinopathy treated with a single PRP injection, were evaluated. The pain intensity (measured by a visual analogue scale (VAS)), the pressure pain threshold (PPT), the grip strength and strength of the main arm and forearm muscle groups, and the functional outcome (measured by the Disability of Arm, Shoulder and Hand (DASH) and Patient-Rated Tennis Elbow Evaluation (PRTEE) questionnaires), were assessed before PRP injection and at one- and three-months follow-up. Flow cytometry measurements of the growth factors and inflammatory cytokines in PRP were performed, and the results were used to establish the relationship between those molecules and the clinical outcome. After three months from the intervention, the minimal clinically important difference in pain reduction and functional improvement was observed in 67% and 83% of patients, respectively. Positive correlations were found between the extent of pain reduction after three months and concentrations in the PRP of platelets, epidermal growth factor (EGF), vascular endothelial growth factor, and platelet-derived growth factors. The concentration of EGF in the PRP significantly correlated with an improvement in grip strength, strength of wrist extensors, and the size of functional improvement measured by the PRTEE. The local injection of PRP is a safe and effective treatment option for lateral elbow tendinopathy, and the clinical outcome is correlated with concentrations of its biologically active compounds.

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Section: Discussionmentioning

confidence: 99%

Effectiveness of Lateral Elbow Tendinopathy Treatment Depends on the Content of Biologically Active Compounds in Autologous Platelet-Rich Plasma

Dejnek

Moreira

Płaczkowska

et al. 2022

JCM

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“…Similarly, recent systematic reviews have also provided conflicting results 46,51,52 . Simental et al performed a meta-analysis of 5 RCTs (n = 276) demonstrating no significant changes in pain (SMD = − 0.51) nor functional scores (SMD = − 0.07) between PRP and placebo injections.…”

Section: Platelet-rich Plasmamentioning

confidence: 99%

“…Similarly, recent systematic reviews have also provided conflicting results 46,51,52 47 . Furthermore, the minimal clinically important difference (MCID) for all the patient-reported outcome measures had exceeded after PRP treatments.…”

Section: Platelet-rich Plasmamentioning

confidence: 99%

Lateral Epicondylitis

et al. 2023

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“…PRP components promote cell recruitment, proliferation, and angiogenesis. It has also been suggested that PRP induces a transient inflammatory response, resulting in a regenerative response and immunomodulatory effects on tenocytes [ 60 ].…”

Section: Lateral Epicondylitismentioning

confidence: 99%

The use of platelet-rich plasma in management of musculoskeletal pain: a narrative review

Thu

2022

J Yeungnam Med Sci

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Musculoskeletal pain is the most common pain reported by patients. Platelet-rich plasma (PRP) is widely used to treat musculoskeletal pain. However, the efficacy of PRP to treat this pain remains controversial. This review highlights the application of PRP in the treatment of musculoskeletal pain. PRP treatment appears to reduce pain and improve function in patients with musculoskeletal pain. However, there are limitations to the currently published studies. These limitations include the PRP preparation methods, type of activators, types of pathology to be treated, methods and times of administration, and association of PRP with other treatments.

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The Efficacy of Platelet-Rich Plasma for Improving Pain and Function in Lateral Epicondylitis: A Systematic Review and Meta-analysis with Risk-of-Bias Assessment

Cited by 20 publications

References 78 publications

Effectiveness of Lateral Elbow Tendinopathy Treatment Depends on the Content of Biologically Active Compounds in Autologous Platelet-Rich Plasma

Effectiveness of Lateral Elbow Tendinopathy Treatment Depends on the Content of Biologically Active Compounds in Autologous Platelet-Rich Plasma

Lateral Epicondylitis

The use of platelet-rich plasma in management of musculoskeletal pain: a narrative review

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