A biolabel research based on metabonomics reveals the therapeutic potentials of Herba Lysimachiae in synovial diseases: The dual effects on synovial platelet aggregation by prostaglandin E1/E2

Li, Xu‐zhao; Li, Hongmei; Zhang, Shuai-nan; Liu, Qi; Wang, Yumei

doi:10.1016/j.jchromb.2021.122726

Cited by 7 publications

(6 citation statements)

References 33 publications

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“…Joint pathway analysis showed that four proteins (OTC, ASL, GLUL and CPS1) and three metabolites ( l ‐aspartate, N ‐acetylaspartylglutamic acid and citric acid) were involved in two key pathways (alanine, aspartate and glutamate metabolism and arginine biosynthesis; Table 1). These endogenous targets were considered as biolabels, which can be used to characterize the mechanism of ST for the management of brain diseases (Li, Li, et al, 2021; Zhang, He, et al, 2021).…”

Section: Resultsmentioning

confidence: 99%

“…The biolabel research pattern is a novel strategy to integratively analyze the therapeutic potential, mechanism and material basis of herbal medicines (Li, Li, et al, 2021; Li, Zhang, et al, 2021; Zhang, He, et al, 2021). Biolabels are unique information groups consisting of herbal medicine‐sensitive targets (e.g.…”

Section: Introductionmentioning

confidence: 99%

“…endogenous metabolites and proteins), which reflect the holistic effects of herbal medicines on living organisms (Li, Zhang, et al, 2021). In our previous studies (Li, Li, et al, 2021; Li, Zhang, et al, 2021; Zhang, He, et al, 2021), multi‐omics have been used for exploring the biolabels of herbs, based on which their therapeutic potential, mechanism and material basis are topologically analyzed using network pharmacology. In the present research, based on the biolabel research pattern, omics and network pharmacology were combined to analyze the therapeutic potential, mechanism and material basis of ST intervention for the management of brain diseases.…”

Section: Introductionmentioning

confidence: 99%

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Omics combined with network pharmacology reveal the neuroprotective mechanism of Sophora tonkinensis based on the biolabel research pattern: The treatment of Parkinson’s disease against oxidative stress and neuroexcitatory toxicity

Zhang

Liu

et al. 2022

Biomedical Chromatography

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Based on the biolabel research pattern, omics and network pharmacology were used for exploring the neuroprotection of Sophora tonkinensis (ST) in the treatment of brain diseases. Multi‐omics were applied to investigate biolabels for ST intervention in brain tissue. Based on biolabels, the therapeutic potential, mechanism and material basis of ST for treating brain diseases were topologically analyzed by network pharmacology. A Parkinson’s disease (PD) mouse model was used to validate biolabel analysis results. Four proteins and three metabolites were involved in two key pathways (alanine, aspartate and glutamate metabolism and arginine biosynthesis) and considered as biolabels. Network pharmacology showed that ST has the potential to treat some brain diseases, especially PD. Eight compounds (including caffeic acid, gallic acid and cinnamic acid) may serve as the material basis of ST treating brain diseases via the mediation of three biolabels. In the PD model, ST and its active compounds (caffeic acid and gallic acid) may protect dopaminergic neurons (maximum recovery rate for dopamine, 49.5%) from oxidative stress (E3 ubiquitin‐protein ligase parkin, reactive oxygen species, nitric oxide, etc.) and neuroexcitatory toxicity (glutamate dehydrogenase, glutamine, glutamic acid, etc.). These findings indicated that omics and network pharmacology may contribute to the achievement of the objectives of this study based on the biolabel research pattern.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Omics combined with network pharmacology reveal the neuroprotective mechanism of Sophora tonkinensis based on the biolabel research pattern: The treatment of Parkinson’s disease against oxidative stress and neuroexcitatory toxicity

Zhang

Liu

et al. 2022

Biomedical Chromatography

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“…The canonical Wnt pathway is also known as the β‐catenin‐dependent Wnt pathway. Stress kinases and intracellular calcium release are among the more minor well‐studied alternative pathways (Li, Li, Zhang, Liu, & Wang, 2021a).…”

Section: Osteoarthritis and Wnt Signalingmentioning

confidence: 99%

Potential role of nutraceuticals via targeting a Wnt/β‐catenin and NF‐κB pathway in treatment of osteoarthritis

Alharbi

Afzal

Altamimi

et al. 2022

Journal of Food Biochemistry

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Osteoarthritis (OA) is a disease due to the aging of the articular cartilage, a post‐mitotic tissue that stays functioning until primary homeostatic processes fail. Because of pain and disability, OA significantly influences national healthcare expenses and patient quality of life. It is a whole‐joint illness characterized by inflammatory and oxidative signaling pathways and significant epigenetic alterations that cause cartilage extracellular matrix degradation. The canonical Wnt pathway (Wnt/β‐catenin pathway) and nuclear factor kappa B (NF‐κB) signaling pathways may function in joint tissues by modulating the activity of synovial cells, osteoblasts, and chondrocytes. However, finding innovative ways to treat osteoarthritis and get the joint back to average balance is still a struggle. Nutraceuticals are dietary supplements that promote joint health by balancing anabolic and catabolic signals. New therapeutic methods for OA treatment have been developed based on many research findings that show nutraceuticals have strong anti‐inflammation, antioxidant, anti–bone resorption, and anabolic properties. For the treatment of osteoarthritis, we explore the possible involvement of nutraceuticals that target the Wnt/β‐catenin and NF‐κB pathways. Practical applications In keeping with the aging population, osteoarthritis is becoming more widespread. In this extensive research, we studied the role of the Wnt/β‐catenin and NF‐κB pathway in OA formation and progression. Nutraceuticals that target these OA‐related signaling pathways are a viable therapy option. Wnt/β‐catenin and NF‐κB signaling pathway are inhibited by polyphenols, flavonoids, alkaloids, and vitamins from the nutraceutical category, making them possible therapeutic drugs for OA therapy.

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“…Biolabels are information groups composed of endogenous targets in living systems that can be used to characterize the effects and mechanisms of herbs (Li et al, 2019). Previous studies have shown that the biolabel‐led research pattern can avoid the limitation of disease models and quickly position the therapeutic potential, mechanism of action, and active compounds of herbs in physiological situations (Li et al, 2020; Li, Li, et al, 2021; Zhang, He, et al, 2021). Metabonomics, proteomics, and bioinformatics belong to systems pharmacology, which can be used to explore the biolabels of herbs (Li et al, 2017; Li et al, 2020; Li et al, 2022; Li, Li, et al, 2021; Zhang et al, 2017; Zhang, He, et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Combination of omics, bioinformatics, molecular docking, and experimental validation to elucidate the hepatoprotective effects, mechanisms, and active compounds of Shandougen

Zhang,

Liu,

2024

Biomedical Chromatography

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Omics, bioinformatics, molecular docking, and experimental validation were used to elucidate the hepatoprotective effects, mechanisms, and active compounds of Shandougen (SDG) based on the biolabel‐led research pattern. Integrated omics were used to explore the biolabels of SDG intervention in liver tissue. Subsequently, bioinformatics and molecular docking were applied to topologically analyze its therapeutic effects, mechanisms, and active compounds based on biolabels. Finally, an animal model was used to verify the biolabel analysis results. Omics, bioinformatics, and molecular docking revealed that SDG may exert therapeutic effects on liver diseases in the multicompound and multitarget synergistic modes, especially liver cirrhosis. In the validation experiment, SDG and its active compounds (betulinic acid and gallic acid) significantly improved the liver histopathological damage in the CCl4‐induced liver cirrhosis model. Meanwhile, they also produced significant inhibitory effects on the focal adhesion pathway (integrin alpha‐1, myosin regulatory light chain 2, laminin subunit gamma‐1, etc.) and alleviated the associated pathological processes: focal adhesion (focal adhesion kinase 1)–extracellular matrix (collagen alpha‐1(IV) chain, collagen alpha‐1(VI) chain, and collagen alpha‐2(VI) chain) dysfunction, carcinogenesis (alpha‐fetoprotein, NH3, and acetylcholinesterase), inflammation (tumor necrosis factor alpha, interleukin‐1 [IL‐1], IL‐6, and IL‐10), and oxidative stress (reactive oxygen species, malonaldehyde, and superoxide dismutase). This study provides new evidence and insights for the hepatoprotective effects, mechanisms, and active compounds of SDG.

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A biolabel research based on metabonomics reveals the therapeutic potentials of Herba Lysimachiae in synovial diseases: The dual effects on synovial platelet aggregation by prostaglandin E1/E2

Cited by 7 publications

References 33 publications

Omics combined with network pharmacology reveal the neuroprotective mechanism of Sophora tonkinensis based on the biolabel research pattern: The treatment of Parkinson’s disease against oxidative stress and neuroexcitatory toxicity

Omics combined with network pharmacology reveal the neuroprotective mechanism of Sophora tonkinensis based on the biolabel research pattern: The treatment of Parkinson’s disease against oxidative stress and neuroexcitatory toxicity

Potential role of nutraceuticals via targeting a Wnt/β‐catenin and NF‐κB pathway in treatment of osteoarthritis

Combination of omics, bioinformatics, molecular docking, and experimental validation to elucidate the hepatoprotective effects, mechanisms, and active compounds of Shandougen

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