Inflammatory Molecules Associated with Ultraviolet Radiation-Mediated Skin Aging

Ansary, Tuba M.; Hossain, Md Razib; Kamiya, Koji; Komine, Mayumi; Ohtsuki, Mamitaro

doi:10.3390/ijms22083974

Cited by 113 publications

(52 citation statements)

References 111 publications

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“…It has been reported that the ability to perform these functions declines with age [ 1 , 2 ]. Skin aging is classified as endogenous aging, also known as chronological aging, and exogenous aging affected by UV, air pollution, alcoholism, and nutritional imbalance [ 3 ]. The major characteristics of aging skin are thinning and reduced turnover of the epidermis, caused by a delayed recovery of skin damage [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Royal Jelly Protects against Epidermal Stress through Upregulation of the NQO1 Expression

Okumura¹,

Ito²,

Degawa³

et al. 2021

IJMS

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Royal jelly (RJ) is secreted by honeybees and has been used as an apitherapy to obtain healthy skin since ancient times. However, the mechanism of the protective effects of RJ against skin aging and skin diseases caused by skin stress and its components have not been clarified. In this study, we attempted to understand the effect of RJ on epidermal function and observed that NAD(P)H quinone dehydrogenase 1 (NQO1) is significantly induced by RJ in keratinocytes. The expression of NQO1 was also increased in the 3D epidermal skin model. NQO1 is involved in antioxidation and detoxification metabolism, and we found that RJ protects against the epidermal stress caused by UVB and menadione through the upregulation of NQO1. We identified 10-hydroxy-2-decenoic acid (10H2DA), a major fatty acid in RJ, as an active compound in this reaction as it induced the expression of NQO1 and protected the skin against oxidative stress. We demonstrated that the protective effect of RJ against epidermal stress is mediated through the upregulation of NQO1 by 10H2DA.

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Section: Introductionmentioning

confidence: 99%

Royal Jelly Protects against Epidermal Stress through Upregulation of the NQO1 Expression

Okumura¹,

Ito²,

Degawa³

et al. 2021

IJMS

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show abstract

“…Skin photoaging caused by UVB exposure over a long period of time causes histological changes, such as irregular changes in keratinocytes, an increase in the number of fibroblasts and inflammatory cells, and an accelerated increase in cross-linked collagen fiber levels in the dermis (Robert et al, 2009). Furthermore, exposure of the skin to UVB also causes ROS production (Ansary et al, 2021;Geng et al, 2021). Exposure to UVB promotes continuous ROS generation in keratinocytes, and ROS are rapidly removed by enzymatic and nonenzymatic methods.…”

Section: Discussionmentioning

confidence: 99%

Photoprotective effects of sphingomyelin-containing milk phospholipids in ultraviolet B–irradiated hairless mice by suppressing nuclear factor-κB expression

Kim

Choi³

et al. 2022

Journal of Dairy Science

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Ceramide-containing phospholipids improve skin hydration and barrier function and are ideal for use in skin care products. In this study, we evaluated the photoprotective effect of milk phospholipids on the skin condition of UVB-irradiated hairless mice. Skin parameters were assessed following oral administration of milk phospholipids. The UVB irradiation induced photoaging in mice. The animals were divided into 5 groups: a control group (oral administration of saline with no UBV irradiation), UVB group (oral administration of saline with UVB irradiation), and 3 UVB irradiation groups receiving the milk phospholipids at 3 different concentrations of oral administration, 50 mg/ kg (ML group), 100 mg/kg (MM group), and 150 mg/ kg (MH group), for 8 wk. An increase in skin hydration and transepidermal water loss were improved in the 150 mg/kg of milk phospholipid-administered group. Hematoxylin and eosin staining revealed a decrease in epidermal thickness in the milk phospholipid-administered groups (50, 100, and 150 mg/kg of body weight). In particular, the 100 and 150 mg/kg groups showed significant changes in the area, length, and depth of the wrinkles compared with the UVB group. Moreover, the gene expression of matrix metalloproteins was attenuated, and that of proinflammatory cytokines, especially tumor necrosis factor-α, was significantly reduced in the milk phospholipid-administered groups than in the UVB group. The reduced ceramide and increased sphingosine-1-phosphate levels in the skin tissue due to UVB exposure were restored to levels similar to those of the control group following milk phospholipid administration. These results were confirmed to be due to the downregulation of protein expression of nuclear factor kappa-B (NF-κB) and phosphorylated IκB-α (inhibitor of κB α). Collectively, oral administration of milk phospholipids improves skin health through a synergistic effect on photoprotective activity.

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“…Cytokines are another important element in the skin aging process [65]. Upon UV radiation, several inflammatory signaling pathways are activated via different surface receptors such as epidermal growth factor receptors, the TGF receptor, Toll-like receptors, the interleukin 1 (IL-1) receptor, and the TNF receptor [66]. Major cytokines secreted from keratinocytes are interleukins (IL-1, IL-3, IL-6, IL-8, IL-33), colony-stimulating factors (CSFs) (granulocyte macrophage [GM]-CSF, M-CSF, G-CSF), TGF-α, TGF-β, TNF-α, and platelet-derived growth factor [67].…”

Section: Cytokines In Aging Skinmentioning

confidence: 99%

“…Telomere shortening In intrinsic aging [48] In chronological aging [49,52] Oxidative stress and matrix metalloproteinases ROS and photoaging [53,55,56] Signal cascade activated by ROS [58,59,61,63,132,133] Cytokines Cytokines released by UV radiation [65][66][67] Tumor necrosis factor α [69] Interleukins [72,73,[77][78][79][80]134] CCN1 [82,83] Autophagic control Association with aging process [92][93][94][95][96][97][98] Apoptosis Association with aging process [104,[107][108][109] MicroRNAs Chronological aging [113][114][115][116][117][118][119]135] photoaging [120][121][122]…”

Section: Molecular Mechanisms Details Referencesmentioning

confidence: 99%

Structural and Functional Changes and Possible Molecular Mechanisms in Aged Skin

Lee

Hong

Kim

2021

IJMS

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Skin aging is a complex process influenced by intrinsic and extrinsic factors. Together, these factors affect the structure and function of the epidermis and dermis. Histologically, aging skin typically shows epidermal atrophy due to decreased cell numbers. The dermis of aged skin shows decreased numbers of mast cells and fibroblasts. Fibroblast senescence contributes to skin aging by secreting a senescence-associated secretory phenotype, which decreases proliferation by impairing the release of essential growth factors and enhancing degradation of the extracellular matrix through activation of matrix metalloproteinases (MMPs). Several molecular mechanisms affect skin aging including telomere shortening, oxidative stress and MMP, cytokines, autophagic control, microRNAs, and the microbiome. Accumulating evidence on the molecular mechanisms of skin aging has provided clinicians with a wide range of therapeutic targets for treating aging skin.

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Inflammatory Molecules Associated with Ultraviolet Radiation-Mediated Skin Aging

Cited by 113 publications

References 111 publications

Royal Jelly Protects against Epidermal Stress through Upregulation of the NQO1 Expression

Royal Jelly Protects against Epidermal Stress through Upregulation of the NQO1 Expression

Photoprotective effects of sphingomyelin-containing milk phospholipids in ultraviolet B–irradiated hairless mice by suppressing nuclear factor-κB expression

Structural and Functional Changes and Possible Molecular Mechanisms in Aged Skin

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