339 Small Animal Pet-Imaging With Scandium-44-Dotatoc

Scandium-44: Benefits of a Long-Lived PET Radionuclide Available from the 44Ti/44Sc Generator System

“…(14). Small Animal PET Images f of 44 Sc-DOTA-TOC in Tumor Bearing Mice for Kidney and Tumor Region, Clearly Demonstrating Prolonged Visualization of the Experimental Tumors even at 17 hours post Injection [28]. Fig.…”

“…Fig. (14) presents small animal PET images for the kidney and tumor region, clearly demonstrating prolonged visualization of the experimental tumors even at 17 hours post injection [28]. prostate carcinomas demonstrated that both tracers were accumulated in the tissue with both tracer showing similar distribution patterns.…”

“…Organ uptake ex vivo and uptake kinetics in vivo of 44 Sc tracers have been investigated for DOTA-octreotide and DOTA-bombesin derivatives as well as for DOTApuromycin derivatives [27,28,29].…”

Cyclotron production of 44Sc: From bench to bedside

“…A single elution of this generator system produced 100-200 MBq 44 Sc, which was successfully employed for the labeling of DOTATOC [15] and in vivo tumor uptake experiments in mice [16]. Typical tumor uptake with a prolonged period of tumor visualization by PET imaging was demonstrated.…”