Cyclotron production of 44Sc: From bench to bedside

Meulen, Nicholas P. van der; Bunka, Maruta; Domnanich, Katharina A.; Müller, Cristina; Haller, Stephanie; Vermeulen, C.; Türler, Andreas; Schibli, Roger

doi:10.1016/j.nucmedbio.2015.05.005

Cited by 87 publications

(100 citation statements)

References 29 publications

(35 reference statements)

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“…Scandium‐44 is receiving current interest owing to its intermediate 3.97 h half‐life, high positron yield, route of production and coordination chemistry . It is typically produced from 44 Ca in a cyclotron, but has the potential to be more conveniently produced via a 44 Ti/ 44 Sc generator system . 44 Sc, which is considered to be a potential alternative to 68 Ga, displays similar coordination chemistry to 68 Ga and could be used to extend the PET scanning window which may result in better images for certain probes .…”

Section: Labelling Strategies and Applicationsmentioning

confidence: 99%

Antibody Fragment and Affibody ImmunoPET Imaging Agents: Radiolabelling Strategies and Applications

Carroll

Yahioglu

et al. 2018

ChemMedChem

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Antibodies have long been recognised as potent vectors for carrying diagnostic medical radionuclides, contrast agents and optical probes to diseased tissue for imaging. The area of ImmunoPET combines the use of positron emission tomography (PET) imaging with antibodies to improve the diagnosis, staging and monitoring of diseases. Recent developments in antibody engineering and PET radiochemistry have led to a new wave of experimental ImmunoPET imaging agents that are based on a range of antibody fragments and affibodies. In contrast to full antibodies, engineered affibody proteins and antibody fragments such as minibodies, diabodies, single‐chain variable region fragments (scFvs), and nanobodies are much smaller but retain the essential specificities and affinities of full antibodies in addition to more desirable pharmacokinetics for imaging. Herein, recent key developments in the PET radiolabelling strategies of antibody fragments and related affibody molecules are highlighted, along with the main PET imaging applications of overexpressed antigen‐associated tumours and immune cells.

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Section: Labelling Strategies and Applicationsmentioning

confidence: 99%

Antibody Fragment and Affibody ImmunoPET Imaging Agents: Radiolabelling Strategies and Applications

Carroll

Yahioglu

et al. 2018

ChemMedChem

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“…RADIOCHEMISTRY AND IMAGING OF 43,44 SC 43,44g Sc has been proposed as a matched-pair theranostic radioisotope that is a longer-lived alternative to 68 Ga for imaging analogs of 177 Lu. Scandium exists in the 13 oxidation state and is suitable for labeling of DOTA-derivatized biomolecules (24). In studies investigating 44g Sc as an imaging surrogate for 177 Lu, 44g Sc-labeled cm09 (DOTAfolate conjugate) was determined to have comparable properties, with pharmacokinetics nearly identical to the same compound labeled with 177 Lu (25).…”

mentioning

confidence: 99%

Production and Use of the First-Row Transition Metal PET Radionuclides^43,44Sc,⁵²Mn, and⁴⁵Ti

Chaple

Lapi

2018

J Nucl Med

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With the increasing focus on a more personalized approach to medicine using imaging techniques to select patients for targeted treatment or theranostic strategies, interest in the development of new radionuclides is expanding. Through the development of production and radiochemistry techniques, several new radiometals are being added to the toolbox of the nuclear imaging community. 43,44g,m Sc, 52g Mn, and 45 Ti are all emerging transition metal radionuclides and will be discussed in this short review. Each of these nuclides has unique imaging characteristics and shows promise for the development of new molecular imaging agents.

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“…Generator produced 44 Sc is eluted from 44 Ti (halflife = 59 years) using an ammonium acetate solution. 169,170 This variety of production methods makes scandium a versatile radiometal that could be widely used in the future, with the source being selected according to the user's requirements. 169,170 This variety of production methods makes scandium a versatile radiometal that could be widely used in the future, with the source being selected according to the user's requirements.…”

Section: Scandium-44mentioning

confidence: 99%

Current advances in ligand design for inorganic positron emission tomography tracers ⁶⁸Ga, ⁶⁴Cu, ⁸⁹Zr and ⁴⁴Sc

2016

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A key part of the development of metal based Positron Emission Tomography probes is the chelation of the radiometal. In this review the recent developments in the chelation of four positron emitting radiometals, Ga,Cu, Zr andSc, are explored. The factors that effect the chelation of each radio metal and the ideal ligand system will be discussed with regards to high in vivo stability, complexation conditions, conjugation to targeting motifs and complexation kinetics. A series of cyclic, cross-bridged and acyclic ligands will be discussed, such as CP256 which forms stable complexes with Ga under mild conditions and PCB-TE2A which has been shown to form a highly stable complex withCu. Zr andSc have seen significant development in recent years with a number of chelates being applied to each metal - eight coordinate di-macrocyclic terephthalamide ligands were found to rapidly produce more stable complexes with Zr than the widely used DFO.

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Cyclotron production of 44Sc: From bench to bedside

Cited by 87 publications

References 29 publications

Antibody Fragment and Affibody ImmunoPET Imaging Agents: Radiolabelling Strategies and Applications

Antibody Fragment and Affibody ImmunoPET Imaging Agents: Radiolabelling Strategies and Applications

Production and Use of the First-Row Transition Metal PET Radionuclides^43,44Sc,⁵²Mn, and⁴⁵Ti

Current advances in ligand design for inorganic positron emission tomography tracers ⁶⁸Ga, ⁶⁴Cu, ⁸⁹Zr and ⁴⁴Sc

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Cyclotron production of 44Sc: From bench to bedside

Cited by 87 publications

References 29 publications

Antibody Fragment and Affibody ImmunoPET Imaging Agents: Radiolabelling Strategies and Applications

Antibody Fragment and Affibody ImmunoPET Imaging Agents: Radiolabelling Strategies and Applications

Production and Use of the First-Row Transition Metal PET Radionuclides43,44Sc,52Mn, and45Ti

Current advances in ligand design for inorganic positron emission tomography tracers 68Ga, 64Cu, 89Zr and 44Sc

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Production and Use of the First-Row Transition Metal PET Radionuclides^43,44Sc,⁵²Mn, and⁴⁵Ti

Current advances in ligand design for inorganic positron emission tomography tracers ⁶⁸Ga, ⁶⁴Cu, ⁸⁹Zr and ⁴⁴Sc