Two-dimensional layered double hydroxide nanoadjuvant: recent progress and future direction

Zhang, Lingxiao; Hu, Jing; Jia, Yingbo; Liu, Rui‐tian; Cai, Ting; Xu, Zhi Ping

doi:10.1039/d1nr00881a

Cited by 53 publications

(43 citation statements)

References 110 publications

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“…A suggested rapid assessment procedure for the introduced indicator CIN 2D was applied to the five most famous 2dNMs, which are important for biomedical applications: graphene nanosheets (GN) and graphene oxide nanosheets (GON) [82] and references within, BNN [83,84], the flat domain of the aloohene [6,[85][86][87], and a single layer of [Mg 2 Al(OH) 6 × Cl] layered double hydroxide (Mg/Al-LDH) [88,89]. One of the most commonly used electrically neutral phospholipids, POPC lipid, was used as the test one.…”

Section: Resultsmentioning

confidence: 99%

Computational Indicator Approach for Assessment of Nanotoxicity of Two-Dimensional Nanomaterials

et al. 2022

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The increasing growth in the development of various novel nanomaterials and their biomedical applications has drawn increasing attention to their biological safety and potential health impact. The most commonly used methods for nanomaterial toxicity assessment are based on laboratory experiments. In recent years, with the aid of computer modeling and data science, several in silico methods for the cytotoxicity prediction of nanomaterials have been developed. An affordable, cost-effective numerical modeling approach thus can reduce the need for in vitro and in vivo testing and predict the properties of designed or developed nanomaterials. We propose here a new in silico method for rapid cytotoxicity assessment of two-dimensional nanomaterials of arbitrary chemical composition by using free energy analysis and molecular dynamics simulations, which can be expressed by a computational indicator of nanotoxicity (CIN2D). We applied this approach to five well-known two-dimensional nanomaterials promising for biomedical applications: graphene, graphene oxide, layered double hydroxide, aloohene, and hexagonal boron nitride nanosheets. The results corroborate the available laboratory biosafety data for these nanomaterials, supporting the applicability of the developed method for predictive nanotoxicity assessment of two-dimensional nanomaterials.

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Section: Resultsmentioning

confidence: 99%

Computational Indicator Approach for Assessment of Nanotoxicity of Two-Dimensional Nanomaterials

et al. 2022

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“…For example, black phosphorous 2D nanosheets can be used in photothermal therapy due to its efficient photothermal conversion property [ 71 ]. Layered double hydroxide can not only perform as lipid regulator to treat CVDs [ 74 ], but can also serve as an immune adjuvant and antigen carrier bi-functional nanoplatform in cancer immunotherapy [ 75 ]. To achieve various biological functions, e.g., magnetic resonance imaging, drug carrying or reactive oxygen species scavenging, appropriate inner nanoparticle selection is essential to fulfill the therapeutic potential of cell membrane coated nanoparticles.…”

Section: Cell Membrane Coated Nanoparticle and Its Applications In Cvdsmentioning

confidence: 99%

Recent Advances of Cell Membrane Coated Nanoparticles in Treating Cardiovascular Disorders

Zhu

et al. 2021

Molecules

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Cardiovascular diseases (CVDs) are the leading cause of death worldwide, causing approximately 17.9 million deaths annually, an estimated 31% of all deaths, according to the WHO. CVDs are essentially rooted in atherosclerosis and are clinically classified into coronary heart disease, stroke and peripheral vascular disorders. Current clinical interventions include early diagnosis, the insertion of stents, and long-term preventive therapy. However, clinical diagnostic and therapeutic tools are subject to a number of limitations including, but not limited to, potential toxicity induced by contrast agents and unexpected bleeding caused by anti-platelet drugs. Nanomedicine has achieved great advancements in biomedical area. Among them, cell membrane coated nanoparticles, denoted as CMCNPs, have acquired enormous expectations due to their biomimetic properties. Such membrane coating technology not only helps avoid immune clearance, but also endows nanoparticles with diverse cellular and functional mimicry. In this review, we will describe the superiorities of CMCNPs in treating cardiovascular diseases and their potentials in optimizing current clinical managements.

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“…Although a large number of reviews have been published on the application of LDH in the fields of supercapacitors, 34,35 electrocatalysis, 36 biomedicine, 37,38 photocatalytic degradation of pollutants 9 and splitting water, 39,40 there are few systematic reviews in the field of photocatalytic reduction of CO 2 . In this review, the photocatalytic theory and the mechanism of photocatalytic reduction of CO 2 over LDH and LDH-based materials are briefly introduced.…”

Section: Introductionmentioning

confidence: 99%

Research progress on photocatalytic reduction of CO₂ based on LDH materials

Guo

et al. 2022

Nanoscale

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Two-dimensional layered double hydroxide nanoadjuvant: recent progress and future direction

Abstract: Layered double hydroxide (LDH) is a ‘sandwich’-like two-dimensional clay material that has been systematically investegated for biomedical application in the past two decades. LDH is an alum-similar adjuvant, which has...

Cited by 53 publications

References 110 publications

Computational Indicator Approach for Assessment of Nanotoxicity of Two-Dimensional Nanomaterials

Computational Indicator Approach for Assessment of Nanotoxicity of Two-Dimensional Nanomaterials

Recent Advances of Cell Membrane Coated Nanoparticles in Treating Cardiovascular Disorders

Research progress on photocatalytic reduction of CO₂ based on LDH materials

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Two-dimensional layered double hydroxide nanoadjuvant: recent progress and future direction

Abstract: Layered double hydroxide (LDH) is a ‘sandwich’-like two-dimensional clay material that has been systematically investegated for biomedical application in the past two decades. LDH is an alum-similar adjuvant, which has...

Cited by 53 publications

References 110 publications

Computational Indicator Approach for Assessment of Nanotoxicity of Two-Dimensional Nanomaterials

Computational Indicator Approach for Assessment of Nanotoxicity of Two-Dimensional Nanomaterials

Recent Advances of Cell Membrane Coated Nanoparticles in Treating Cardiovascular Disorders

Research progress on photocatalytic reduction of CO2 based on LDH materials

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Product

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Research progress on photocatalytic reduction of CO₂ based on LDH materials