A Comparative Biology of Microglia Across Species

Sharma, Kaushik; Bisht, Kanchan; Eyo, Ukpong B.

doi:10.3389/fcell.2021.652748

Cited by 18 publications

(21 citation statements)

References 147 publications

(123 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Early entry and the brain colonization enables microglia to perform critical roles in regulating important events of early brain development e.g., neurons' survival, phagocytosis of dying neurons, synaptogenesis, angiogenesis, axons development (8).…”

Section: Microgliamentioning

confidence: 99%

“…In the prenatal and early postnatal phase, microglia actively participate in brain development by stimulating neurogenesis and gliogenesis (e.g., oligodendrocytes), and the brain vasculature. Microglia regulate the neural circuit wiring, apoptosis and survival of neurons, synapse formation and functioning, and myelination (5,8). Thus, microglia are considered either a causal or a contributing factor to almost all brain disorders, from neurodevelopmental disorders to neurodegeneration.…”

Section: Microgliamentioning

confidence: 99%

“…Activated microglia can influence other glial cells and increase the BBB permeability (5,13). Thus, activated microglia enhance their phagocytic functions in order to clear the damaged tissue from remnants of myelin, cellular debris, apoptotic bodies, and pathogens (5,8).…”

Section: Microgliamentioning

confidence: 99%

“…There have been trials to define a precise molecular signature of microglial cells (5,8). Microglia have a unique gene signature determined by the microglia-specific genes, such as Tmem119, P2ry12, Sall1, and Olfml3 (59).…”

Section: Microgliamentioning

confidence: 99%

See 3 more Smart Citations

Neuroglia — development and role in physiological and pathophysiological processes

et al. 2021

View full text Add to dashboard Cite

show abstract

Section: Microgliamentioning

confidence: 99%

Section: Microgliamentioning

confidence: 99%

Section: Microgliamentioning

confidence: 99%

Section: Microgliamentioning

confidence: 99%

See 2 more Smart Citations

Neuroglia — development and role in physiological and pathophysiological processes

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Studying microglia requires the ability to image a wide field of view (due to their migratory nature), deep into tissue at a high temporal and spatial resolution which is difficult to achieve in larger mammalian brains. Microglia are present in both mammalian and non-mammalian vertebrates, and microglia-like cells have been extensively described in invertebrate annelids ( Sharma et al, 2021 ). The existence of distinct microglia in other invertebrates, such as Drosophila , is less clear and suggests they may have arisen convergently in annelids ( Hartenstein and Giangrande, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

A Model of Discovery: The Role of Imaging Established and Emerging Non-mammalian Models in Neuroscience

Haynes

Ulland

Eliceiri

2022

Front. Mol. Neurosci.

View full text Add to dashboard Cite

Rodents have been the dominant animal models in neurobiology and neurological disease research over the past 60 years. The prevalent use of rats and mice in neuroscience research has been driven by several key attributes including their organ physiology being more similar to humans, the availability of a broad variety of behavioral tests and genetic tools, and widely accessible reagents. However, despite the many advances in understanding neurobiology that have been achieved using rodent models, there remain key limitations in the questions that can be addressed in these and other mammalian models. In particular, in vivo imaging in mammals at the cell-resolution level remains technically difficult and demands large investments in time and cost. The simpler nervous systems of many non-mammalian models allow for precise mapping of circuits and even the whole brain with impressive subcellular resolution. The types of non-mammalian neuroscience models available spans vertebrates and non-vertebrates, so that an appropriate model for most cell biological questions in neurodegenerative disease likely exists. A push to diversify the models used in neuroscience research could help address current gaps in knowledge, complement existing rodent-based bodies of work, and bring new insight into our understanding of human disease. Moreover, there are inherent aspects of many non-mammalian models such as lifespan and tissue transparency that can make them specifically advantageous for neuroscience studies. Crispr/Cas9 gene editing and decreased cost of genome sequencing combined with advances in optical microscopy enhances the utility of new animal models to address specific questions. This review seeks to synthesize current knowledge of established and emerging non-mammalian model organisms with advances in cellular-resolution in vivo imaging techniques to suggest new approaches to understand neurodegeneration and neurobiological processes. We will summarize current tools and in vivo imaging approaches at the single cell scale that could help lead to increased consideration of non-mammalian models in neuroscience research.

show abstract

Artificial intelligence for neurodegenerative experimental models

Marzi,

Schilder,

Nott

et al. 2023

Alzheimer's & Dementia

View full text Add to dashboard Cite

INTRODUCTIONExperimental models are essential tools in neurodegenerative disease research. However, the translation of insights and drugs discovered in model systems has proven immensely challenging, marred by high failure rates in human clinical trials.METHODSHere we review the application of artificial intelligence (AI) and machine learning (ML) in experimental medicine for dementia research.RESULTSConsidering the specific challenges of reproducibility and translation between other species or model systems and human biology in preclinical dementia research, we highlight best practices and resources that can be leveraged to quantify and evaluate translatability. We then evaluate how AI and ML approaches could be applied to enhance both cross‐model reproducibility and translation to human biology, while sustaining biological interpretability.DISCUSSIONAI and ML approaches in experimental medicine remain in their infancy. However, they have great potential to strengthen preclinical research and translation if based upon adequate, robust, and reproducible experimental data.Highlights There are increasing applications of AI in experimental medicine. We identified issues in reproducibility, cross‐species translation, and data curation in the field. Our review highlights data resources and AI approaches as solutions. Multi‐omics analysis with AI offers exciting future possibilities in drug discovery.

show abstract

A Comparative Biology of Microglia Across Species

Cited by 18 publications

References 147 publications

Neuroglia — development and role in physiological and pathophysiological processes

Neuroglia — development and role in physiological and pathophysiological processes

A Model of Discovery: The Role of Imaging Established and Emerging Non-mammalian Models in Neuroscience

Artificial intelligence for neurodegenerative experimental models

Contact Info

Product

Resources

About