Light modulates the effect of antibiotic norfloxacin on photosynthetic processes of Microcystis aeruginosa

Lu, Zhao; Xu, Kui; Juneau, Philippe; Huang, Peihuan; Lian, Yingli; Zheng, Xiaoming; Zhong, Qiuping; Zhang, Wei; Xiao, Fanshu; Wu, Bo; Yan, Qingyun; He, Zhili

doi:10.1016/j.aquatox.2021.105826

Cited by 15 publications

(3 citation statements)

References 63 publications

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“…However, in the same species, Lützhøft and colleagues reported EC 50s of 15 µg L −1 for sarafloxacin and 159 µg L −1 for flumequine [ 247 ]; whilst Halling-Sorensen and colleagues reported an EC 50 of 5 µg L −1 for ciprofloxacin [ 246 ]. In another study, it was found that the effects of norfloxacin on M. aeruginosa were modulated by light, the lowest EC 50 being around 45 µg L −1 at high light intensity [ 249 ]. Ciprofloxacin was very toxic also to Microcystis panniformis , with an EC 50 of 13.56 µg L −1 [ 171 ].…”

Section: Toxicity Of Fqs To Freshwater Organismsmentioning

confidence: 99%

A Review on Fluoroquinolones’ Toxicity to Freshwater Organisms and a Risk Assessment

Pauletto,

De Liguoro

2024

JoX

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Fluoroquinolones (FQs) have achieved significant success in both human and veterinary medicine. However, regulatory authorities have recommended limiting their use, firstly because they can have disabling side effects; secondly, because of the need to limit the spread of antibiotic resistance. This review addresses another concerning consequence of the excessive use of FQs: the freshwater environments contamination and the impact on non-target organisms. Here, an overview of the highest concentrations found in Europe, Asia, and the USA is provided, the sensitivity of various taxa is presented through a comparison of the lowest EC50s from about a hundred acute toxicity tests, and primary mechanisms of FQ toxicity are described. A risk assessment is conducted based on the estimation of the Predicted No Effect Concentration (PNEC). This is calculated traditionally and, in a more contemporary manner, by constructing a normalized Species Sensitivity Distribution curve. The lowest individual HC5 (6.52 µg L−1) was obtained for levofloxacin, followed by ciprofloxacin (7.51 µg L−1), sarafloxacin and clinafloxacin (12.23 µg L−1), and ofloxacin (17.12 µg L−1). By comparing the calculated PNEC with detected concentrations, it is evident that the risk cannot be denied: the potential impact of FQs on freshwater ecosystems is a further reason to minimize their use.

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Section: Toxicity Of Fqs To Freshwater Organismsmentioning

confidence: 99%

A Review on Fluoroquinolones’ Toxicity to Freshwater Organisms and a Risk Assessment

Pauletto,

De Liguoro

2024

JoX

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“…With the rising antibiotic consumption, most antibiotics are not fully metabolized by the livestock and ultimately accumulate in water and soils . Norfloxacin (NOR), a typical fluoroquinolone antibiotic, is active against Gram bacteria, restraining cell division and does not combine with DNA . It is applied to pharmaceuticals industry extensively.…”

Section: Introductionmentioning

confidence: 99%

“…1 Norfloxacin (NOR), a typical fluoroquinolone antibiotic, is active against Gram bacteria, restraining cell division and does not combine with DNA. 2 It is applied to pharmaceuticals industry extensively. Additionally, due to the stable chemical structures, norfloxacin in the environment could not be effectively eliminated or degraded by traditional treatment processes, such as adsorption, 3 biodegradation, 4,5 sludge digestion, 6 and photocatalytic degradation.…”

Section: Introductionmentioning

confidence: 99%

Norfloxacin Degradation by Persulfate Activated with Cu₂O@WO₃ Composites: Efficiency, Stability, Mechanism, and Degradation Pathway

Cai

et al. 2022

Ind. Eng. Chem. Res.

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Tungsten trioxide and cuprous oxide composites were successfully prepared by the solvothermal and coprecipitation method. The obtained composites were comprehensively characterized using scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transform-infrared spectroscopy (FT-IR), Raman, and PL spectroscopy. The Cu2O@WO3/PS system was developed to degrade norfloxacin (NOR) in an aqueous solution. The photodegradation experiments and electrochemical characterization (EIS and photocurrent curves) showed that Cu2O@WO3(2–1) exhibited optimal photocatalytic activity under visible light. Furthermore, the sulfate radical was corroborated to play a predominant role in the photodegradation process, and the possible free radical formation mechanism was put forward. Density functional theory (DFT) calculation and LC-MS were utilized to investigate the intermediates during NOR degradation, and three possible degradation pathways were elucidated. Ecotoxicity analysis by TEST showed that the toxicity of these intermediates was generally weaker than parent NOR. Moreover, the synthetic sample was authenticated to possess good stability and repeatability. This work provided the guidance for available and applicable utilization of persulfate photocatalytic activation technology in pharmaceutical wastewater purification.

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Effects of four antibiotics on the photosynthetic light reactions in the green alga Chlorella pyrenoidosa

Wang,

Liu,

et al. 2024

Comparative Biochemistry and Physiology Part C: Toxicology &

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Light modulates the effect of antibiotic norfloxacin on photosynthetic processes of Microcystis aeruginosa

Cited by 15 publications

References 63 publications

A Review on Fluoroquinolones’ Toxicity to Freshwater Organisms and a Risk Assessment

A Review on Fluoroquinolones’ Toxicity to Freshwater Organisms and a Risk Assessment

Norfloxacin Degradation by Persulfate Activated with Cu₂O@WO₃ Composites: Efficiency, Stability, Mechanism, and Degradation Pathway

Effects of four antibiotics on the photosynthetic light reactions in the green alga Chlorella pyrenoidosa

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Light modulates the effect of antibiotic norfloxacin on photosynthetic processes of Microcystis aeruginosa

Cited by 15 publications

References 63 publications

A Review on Fluoroquinolones’ Toxicity to Freshwater Organisms and a Risk Assessment

A Review on Fluoroquinolones’ Toxicity to Freshwater Organisms and a Risk Assessment

Norfloxacin Degradation by Persulfate Activated with Cu2O@WO3 Composites: Efficiency, Stability, Mechanism, and Degradation Pathway

Effects of four antibiotics on the photosynthetic light reactions in the green alga Chlorella pyrenoidosa

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Norfloxacin Degradation by Persulfate Activated with Cu₂O@WO₃ Composites: Efficiency, Stability, Mechanism, and Degradation Pathway