Exposure to endocrine disruptors and risk of breast cancer: A systematic review

Rocha, Priscilla Roberta Silva; Oliveira, Valdiane Dutra; Vasques, Christiane Inocêncio; Reis, Paula Elaine Diniz dos; Amato, Angélica Amorim

doi:10.1016/j.critrevonc.2021.103330

Cited by 38 publications

(12 citation statements)

References 87 publications

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“…The causes of breast cancer are constantly being updated by researchers. Some established breast cancer risk factors include early age at giving first birth, genetic inheritance [21,22], an unhealthy lifestyle [23], and hazardous environmental exposure [24] that can explain a significant part of breast cancer incidence. Among the proposed risk factors, environmental chemical pollution may increasingly affect the signaling pathways involved in the emergence and progression of metastatic tumor cells.…”

Section: Discussionmentioning

confidence: 99%

Associations between Polyfluoroalkyl Substances Exposure and Breast Cancer: A Meta-Analysis

Jiang

Liu

et al. 2022

Toxics

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Polyfluoroalkyl substances (PFASs) are persistent pollutants that may cause breast cancer. However, associations between exposure to PFASs and the risk of breast cancer are controversial. We retrieved studies on the association between PFASs—perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorohexane sulfonic acid (PFHxS), and perfluorooctane sulfonic acid (PFOS)—and breast cancer risk in women from PubMed, Embase, and the Web of Science. The pooled odds ratios (ORs) or relative risks (RRs) and their 95% confidence intervals (CIs) were extracted or calculated from provided data. Moreover, subgroup and metaregression analyses were performed to distinguish the potential sources of heterogeneity between studies. Lastly, eight original studies were included in the meta-analysis. PFOA and PFHxS were positively correlated with breast cancer risk, and the pooled ORs (and 95% CIs) were 1.32 (1.19 and 1.46) and 1.79 (1.51 and 2.11), respectively. PFNA was negatively correlated with breast cancer risk and the pooled OR (and 95% CIs) was 0.76 (0.6 and 0.96), and PFOS was shown to have no correlation with breast cancer risk and the pooled OR (and 95% CIs) was 1.01 (0.87 and 1.17). All results were merged in a random-effects model with significant heterogeneities (I2 > 90%, p < 0.001). The results demonstrated that PFASs might be potential risk factors for breast cancer, and the compounds in low exposure levels could have a more harmful impact on human health.

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Section: Discussionmentioning

confidence: 99%

Associations between Polyfluoroalkyl Substances Exposure and Breast Cancer: A Meta-Analysis

Jiang

Liu

et al. 2022

Toxics

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“…Research has shown that BPA exhibits genotoxicity, reproductive toxicity, endocrine-disrupting activity, cytotoxicity, neurotoxicity and hepatotoxicity [232]. In women, its presence in the environment has been linked to breast cancer [234], polycystic ovary syndrome, miscarriage, endometrial disorders and premature birth [9,213,230]. In men, BPA has been associated with lower semen quality, fertility, sex hormone levels and sexual dysfunction.…”

Section: Plasticizersmentioning

confidence: 99%

Biochemical Characteristics of Laccases and their Practical Application in the Removal of Xenobiotics from Waters

Gałązka¹,

Jankiewicz²,

Szczepkowski³

2023

Preprint

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Industrialization, intensive farming, rapid population growth and urbanization are the source of a large number of pollutants entering the environment. The current concentration of xenobiotics released into the environment exceeds its natural ability to decompose them. Enzymatic degradation of pollutants seems to be an environmentally friendly process. Due to the wide spectrum of substrate specificity, from inorganic compounds to high molecular weight organic compounds such as PAH or dyes, as well as favorable biochemical properties, laccase has been used in the biological removal of xenobiotics from the environment. It is important to understand the degradation mechanisms of pollutants and to evaluate the final products in terms of their toxicity. The laccase oxidizes the substrates with the simultaneous reduction of molecular oxygen to water, which is the purest reaction co-substrate. That is why it is called a green biocatalyst. The trend is an increase in the production of enzymes related to the intensive development of industry, bioremediation or synthetic chemistry. This leads to the search for laccases with greater activity and stability under extreme conditions. The potential of laccases to degrade xenobiotics can be promoted by improving enzymatic catalytic characterization using protein engineering and other genetic engineering methods.

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“…A growing number of studies have investigated the correlations between EDs and BC onset and progression [41]. Before the mammary gland development is completed, within the third trimester of the first pregnancy, breast tissue is particularly prone to carcinogenic effects and a prolonged exposure to low levels of EDs [42][43][44], can lead to an increased risk of carcinoma in upcoming years [45,46].…”

Section: Synthetic Endocrine Disruptorsmentioning

confidence: 99%

Endocrine Disruptors in Food, Estrobolome and Breast Cancer

Filippone¹,

Rossi²,

Rossi³

et al. 2022

Preprint

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The microbiota is now recognized as one of the major players in human health and disease, in-cluding cancer. As regards breast cancer (BC), a clear link between microbiota and oncogenesis is still to be confirmed. Yet, part of the bacterial gene mass inside the gut, constituting the so called “estrobolome”, influences the sexual hormonal balance and, since the increased exposure to estrogens is associated with an increased risk, it may impact on the onset, progression, and treatment of hormonal dependent cancers, which account for more than 70% of all BCs. The hormonal dependent BCs are also affected by environmental and dietary endocrine disruptors and phytoestrogens which interact with microbiota in a bidirectional way: on one side disruptors can alter the composition and functions of the estrobolome, on the other the gut microbiota influences the metabolism of endocrine active food components. This review highlights the current evidence about the complex interplay between endocrine disruptors, phytoestrogens, microbiome, and BC, within the frames of a new “oncobiotic” perspective.

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Exposure to endocrine disruptors and risk of breast cancer: A systematic review

Cited by 38 publications

References 87 publications

Associations between Polyfluoroalkyl Substances Exposure and Breast Cancer: A Meta-Analysis

Associations between Polyfluoroalkyl Substances Exposure and Breast Cancer: A Meta-Analysis

Biochemical Characteristics of Laccases and their Practical Application in the Removal of Xenobiotics from Waters

Endocrine Disruptors in Food, Estrobolome and Breast Cancer

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