Impact of the presence of heart disease, cardiovascular medications and cardiac events on outcome in COVID-19

Villalba, Gonzalo Cabezón; Amat‐Santos, Ignacio J.; Dueñas, Carlos; Otero, Diego López; Catalá, Pablo; Alonso, Álvaro; López-País, Javier; Cacho-Antonio, Carla; Candela, Jordi; Muiños, Pablo Antúnez; Gil, José Francisco López; Ferrero, T Gonzalez; Marcos, Marta; Pérez-Poza, Marta; Rojas, Gino; García, O. Otero; Veras, Carlos; Ramos, Vítor; Uribarri, Aitor; Revilla, Ana; García‐Granja, Pablo Elpidio; Gómez, Itzíar; González-Juanatey, José Ramón; Román, José Alberto San

doi:10.5603/cj.a2021.0034

Cited by 14 publications

(9 citation statements)

References 31 publications

(41 reference statements)

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“…The reason for the increased number of cases is not only due to severe respiratory failure but also cardiac and vascular complications during and after infection [ 5 ]. Ultimately, cardiopulmonary resuscitation in patients with OHCA is associated with poor prognosis, and the COVID-19 pandemic may have worsened morbidity and mortality by impacting individual health and by crowding the healthcare system [ 9 , 10 , 11 , 12 ]. Critically ill COVID-19 patients may experience cardiac arrest, not only during acute hospitalization but also during rehabilitation and postrecovery periods [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

The Influence of COVID-19 on Out-Hospital Cardiac Arrest Survival Outcomes: An Updated Systematic Review and Meta-Analysis

Bielski

Szarpak²,

Jaguszewski

et al. 2021

JCM

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Cardiopulmonary resuscitation in patients with out-of-hospital cardiac arrest (OHCA) is associated with poor prognosis. Because the COVID-19 pandemic may have impacted mortality and morbidity, both on an individual level and the health care system as a whole, our purpose was to determine rates of OHCA survival since the onset of the SARS-CoV2 pandemic. We conducted a systematic review and meta-analysis to evaluate the influence of COVID-19 on OHCA survival outcomes according to the PRISMA guidelines. We searched the literature using PubMed, Scopus, Web of Science and Cochrane Central Register for Controlled Trials databases from inception to September 2021 and identified 1775 potentially relevant studies, of which thirty-one articles totaling 88,188 patients were included in this meta-analysis. Prehospital return of spontaneous circulation (ROSC) in pre-COVID-19 and COVID-19 periods was 12.3% vs. 8.9%, respectively (OR = 1.40; 95%CI: 1.06–1.87; p < 0.001). Survival to hospital discharge in pre- vs. intra-COVID-19 periods was 11.5% vs. 8.2% (OR = 1.57; 95%CI: 1.37–1.79; p < 0.001). A similar dependency was observed in the case of survival to hospital discharge with the Cerebral Performance Category (CPC) 1–2 (6.7% vs. 4.0%; OR = 1.71; 95%CI: 1.35–2.15; p < 0.001), as well as in the 30-day survival rate (9.2% vs. 6.4%; OR = 1.63; 95%CI: 1.13–2.36; p = 0.009). In conclusion, prognosis of OHCA is usually poor and even worse during COVID-19.

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Section: Introductionmentioning

confidence: 99%

The Influence of COVID-19 on Out-Hospital Cardiac Arrest Survival Outcomes: An Updated Systematic Review and Meta-Analysis

Bielski

Szarpak²,

Jaguszewski

et al. 2021

JCM

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“…Cardiovascular disease is a risk factor for hospitalization in patients with respiratory viral infection, and is a contributor to cardiovascular complications and worsened in-hospital outcomes in this population [1] , [2] , [3] . These findings were replicated in studies with patients admitted to the hospital with SARS-CoV-2 infection during the current COVID-19 pandemic [4] , [5] , [6] . Before SARS-CoV-2, the strongest link between cardiovascular disease and worsened in-hospital outcomes for respiratory viral infections was found for influenza, an illness that affected 37.4 to 42.9 million individuals in the United States in the 2018–2019 season [7] .…”

Section: Introductionmentioning

confidence: 64%

Effects of atrial fibrillation on outcomes of influenza hospitalization

Bolton

Thyagaturu

Ashraf

et al. 2022

IJC Heart & Vasculature

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“…As per our inclusion criteria, all cohort studies were based in Europe and included 23 studies from Spain (14, 16, 17, 22, 28, 29, 32, 33, 35, 50, 54, 57-59, 64, 67, 70, 80, 89, 92, 96, 97, 101), 22 studies from Italy(13, 19, 21, 23, 25, 30, 38, 39, 45, 47, 48, 55, 56, 61, 62, 68, 71, 77, 79, 90, 91, 93), 15 studies from France (20, 24, 27, 31, 40, 41, 43, 53, 60, 63, 65, 74, 76, 86, 99), ten studies from the UK (26, 34, 44, 49, 52, 66, 72, 75, 87, 98), four included patients from more than one country (69, 73, 88, 94), three from Germany (46, 51, 78), two studies from Sweden(36, 100), two from Denmark (42, 83) and one study from Belgium (81), Finland (5), the Netherlands (18), Norway (85) and Poland (37). The diagnosis of COVID-19 was made mainly with a PCR test, except for in five studies in which the diagnosis was made with the ICD Classification (20, 24, <...>…”

Section: Resultsmentioning

confidence: 99%

Prognostic factors for mortality, ICU and hospital admission due to SARS-CoV-2: A systematic review and meta-analysis of cohort studies in Europe

Vardavas

Mathioudakis

Nikitara

et al. 2022

Preprint

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Background: As mortality from COVID-19 is strongly age-dependent, we aimed to identify population subgroups at an elevated risk for adverse outcomes from COVID-19 using age/gender-adjusted data from European cohort studies with the aim to identify populations that could potentially benefit from booster vaccinations. Methods: We performed a systematic literature review and meta-analysis to investigate the role of underlying medical conditions as prognostic factors for adverse outcomes due to SARS-CoV-2, including death, hospitalisation, Intensive Care Unit (ICU) admission, and mechanical ventilation within three separate settings (community, hospital and ICU). Cohort studies that reported at least age and gender-adjusted data from Europe were identified through a search of peer-reviewed articles published until 11th June 2021 in Ovid Medline and Embase. Results are presented as Odds Ratios (ORs) with 95% confidence intervals (95%C.I.) and absolute risk differences (RD) in deaths per 1,000 COVID-19 patients. Findings: We included 88 cohort studies with age/gender adjusted data from 6,653,207 SARS-CoV-2 patients from Europe. Hospital-based mortality was associated with high and moderate certainty evidence for solid organ tumours, diabetes mellitus, renal disease, arrhythmia, ischemic heart disease, liver disease, and obesity, while a higher risk, albeit with low certainty, was noted for chronic obstructive pulmonary disease and heart failure. Community-based mortality was associated with a history of heart failure, stroke, diabetes, and end-stage renal disease. Evidence of high/moderate certainty revealed a strong association between hospitalisation for COVID-19 and solid organ transplant recipients, sleep apnoea, diabetes, stroke, and liver disease. Interpretation: The results confirmed the strong association between specific prognostic factors and mortality and hospital admission. Prioritisation of booster vaccinations and the implementation of non-pharmaceutical protective measures for these populations may contribute to a reduction in COVID-19 mortality, ICU and hospital admissions. Funding: European Centre for Disease Prevention and Control (ECDC) under specific contract No. 10 ECD.11843 within Framework contract ECDC/2019/001 Lot 1B.

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Impact of the presence of heart disease, cardiovascular medications and cardiac events on outcome in COVID-19

Abstract: This article has been peer reviewed and published immediately upon acceptance.It is an open access article, which means that it can be downloaded, printed, and distributed freely, provided the work is properly cited. Articles in "Cardiology Journal" are listed in PubMed.

Cited by 14 publications

References 31 publications

The Influence of COVID-19 on Out-Hospital Cardiac Arrest Survival Outcomes: An Updated Systematic Review and Meta-Analysis

The Influence of COVID-19 on Out-Hospital Cardiac Arrest Survival Outcomes: An Updated Systematic Review and Meta-Analysis

Effects of atrial fibrillation on outcomes of influenza hospitalization

Prognostic factors for mortality, ICU and hospital admission due to SARS-CoV-2: A systematic review and meta-analysis of cohort studies in Europe

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