Effects of atrial fibrillation on outcomes of influenza hospitalization

Bolton, Alexander; Thyagaturu, Harshith; Ashraf, Muddasir; Carnahan, Ryan M.; Hodgson-Zingman, Denice

doi:10.1016/j.ijcha.2022.101106

Cited by 2 publications

(2 citation statements)

References 38 publications

(43 reference statements)

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“…Influenza infection increases the risk of developing A-fib and flu vaccination tend to downregulate this risk by 18% [ 36 ]. Influenza seems to incite A-fib through direct cardiomyocyte invasion, pro-inflammatory cytokine production and increased sympathetic tone, all of which are instrumental in instigating electrophysical changes necessary for generating arrhythmogenic foci [ 36 , 37 ]. Influenza A virus infected hearts exhibit altered cardiac proteome which specifies high stress and low energy state [ 38 ].…”

Section: Main Textmentioning

confidence: 99%

COVID-19 HEART unveiling as atrial fibrillation: pathophysiology, management and future directions for research

2023

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Background COVID-19 infections are known to cause numerous systemic complications including cardiovascular disorders. In this regard, clinicians recently noticed that patients recovering from COVID-19 infections presented with diverse set of cardiovascular disorders in addition to those admitted to ICU (intensive care unit). COVID-19 heart has multifaceted presentation ranging from dysrhythmias, myocarditis, stroke, coronary artery disease, thromboembolism to heart failure. Atrial fibrillation is the most common cardiac arrhythmia among COVID-19 patients. In the background section, we briefly discussed epidemiology and spectrum of cardiac arrhythmias in COVID-19 patients. Main body In this state-of-the-art review we present here, we present the information regarding COVID-19-induced A-fib in sections, namely mechanism of action, clinical presentation, diagnosis and treatment. Unfortunately, its occurrence significantly increases the mortality and morbidity with a potential risk of complications such as cardiac arrest and sudden death. We included separate sections on complications including thromboembolism and ventricular arrhythmias. Since its mechanism is currently a gray area, we included a separate section on basic science research studies that are warranted in the future to comprehend its underlying pathogenic mechanisms. Conclusions Taken together, this review builds upon the current literature of COVID-19-induced A-fib, including pathophysiology, clinical presentation, treatment and complications. Furthermore, it provides recommendations for future research moving forward that can open avenues for developing novel remedies that can prevent as well as hasten clinical recovery of atrial fibrillation in COVID-19 patients.

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Section: Main Textmentioning

confidence: 99%

COVID-19 HEART unveiling as atrial fibrillation: pathophysiology, management and future directions for research

2023

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“…Patients with underlying atrial fibrillation have a worse prognosis with influenza infection [25]. Influenza infection also increases the risk of haemorrhagic [26] and ischaemic stroke [27] in patients with atrial fibrillation.…”

Section: Cardiac-related Diseasesmentioning

confidence: 99%

Review of Vaccination Recommendations in Guidelines for Non-Communicable Diseases with Highest Global Disease Burden among Adults 75 Years Old and Above

et al. 2023

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This scientific review paper explores international and country-specific healthcare guidelines for non-communicable diseases with the highest burden among individuals aged 75 years and above. The study aims to identify the best vaccination practices and standardize healthcare practices to improve vaccination adherence in this vulnerable population. Given that older people are more prone to infectious illnesses and have higher rates of morbidity and mortality, vaccinations are essential for disease prevention. Despite the proven efficacy of vaccinations, adherence has plateaued in recent years, partly due to a lack of accessibility, public education, and variability in disease-specific guidelines. This paper highlights the need for a more robust and standardized international vaccination model to improve quality of life and reduce disability-adjusted life years among the elderly. The findings of this study call for further research to review the guidelines as more implementations are put in place, including non-English guidelines.

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Effects of atrial fibrillation on outcomes of influenza hospitalization

Cited by 2 publications

References 38 publications

COVID-19 HEART unveiling as atrial fibrillation: pathophysiology, management and future directions for research

COVID-19 HEART unveiling as atrial fibrillation: pathophysiology, management and future directions for research

Review of Vaccination Recommendations in Guidelines for Non-Communicable Diseases with Highest Global Disease Burden among Adults 75 Years Old and Above

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