Development of X-ray contrast agents using single nanometer-sized gold nanoparticles and lactoferrin complex and their application in vascular imaging

Inose, Tomoya; Kitamura, Narufumi; Takano-Kasuya, Mayumi; Tokunaga, Masayuki; Une, Norikazu; Kato, C.; Tayama, Mayu; Kobayashi, Y.; Yamauchi, Noriko; Nagao, Daisuke; Aimiya, Takuji; Furusawa, Naoko; Nakano, Yukiko; Kobayashi, Yoshio; Gonda, Kohsuke

doi:10.1016/j.colsurfb.2021.111732

Cited by 11 publications

(2 citation statements)

References 22 publications

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“…AuNPs in medical applications have sparked attention in recent decades due to their intrinsic features, which make them suited for cancer diagnosis and treatment. AuNPs, like many valuable metals, have a superior optical feature called surface plasmon resonance (SPR), which permits them to be employed in near-infrared (NIR) resonant medical imaging modalities, including computed tomography (CT) [5], X-ray scatter imaging [6],…”

Section: Introductionmentioning

confidence: 99%

Monodisperse Gold Nanoparticles: A Review on Synthesis and Their Application in Modern Medicine

Dheyab

Aziz

Khaniabadi

et al. 2022

IJMS

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Gold nanoparticles (AuNPs) are becoming increasingly popular as drug carriers due to their unique properties such as size tenability, multivalency, low toxicity and biocompatibility. AuNPs have physical features that distinguish them from bulk materials, small molecules and other nanoscale particles. Their unique combination of characteristics is just now being fully realized in various biomedical applications. In this review, we focus on the research accomplishments and new opportunities in this field, and we describe the rising developments in the use of monodisperse AuNPs for diagnostic and therapeutic applications. This study addresses the key principles and the most recent published data, focusing on monodisperse AuNP synthesis, surface modifications, and future theranostic applications. Moving forward, we also consider the possible development of functionalized monodisperse AuNPs for theranostic applications based on these efforts. We anticipate that as research advances, flexible AuNPs will become a crucial platform for medical applications.

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Section: Introductionmentioning

confidence: 99%

Monodisperse Gold Nanoparticles: A Review on Synthesis and Their Application in Modern Medicine

Dheyab

Aziz

Khaniabadi

et al. 2022

IJMS

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“…To reduce tissue retention of AuNPs, ultrasmall gold nanoclusters with renal clearance ability were developed for imaging and sensing [6,7]. Nevertheless, they were not reported for PTT use.…”

Section: Introductionmentioning

confidence: 99%

Facile preparation of Au- and BODIPY-grafted lipid nanoparticles for synergized photothermal therapy

Wang¹,

Li²,

Chen³

et al. 2022

Beilstein J. Nanotechnol.

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Gold nanoparticles with large size exhibit preferable properties for photothermal therapy (PTT). However, the prolonged tissue retention and slow elimination of gold nanoparticles limit their therapeutic applications. Previously, gold nanoclusters carrying lipid nanoparticles (Au-LNPs) have been reported after simply mixing Au3+ with preformed diethylenetriaminepentaacetic acid lipid nanoparticles to solve this contradiction. Au-LNPs demonstrated enhanced photothermal effects in comparison to neat gold nanoparticles. To further improve the photothermal activity, we introduced the organic photothermal agent boron dipyrromethene (BODIPY) to Au-LNPs for synergistic PTT. Au- and BODIPY-grafted LNPs (AB-LNPs) were formed by simply mixing Au-LNPs with BODIPY. The BODIPY could be associated stably to Au-LNPs, and the release of BODIPY from AB-LNPs could be accelerated by laser irradiation. AB-LNPs are scalable and showed excellent photothermal effects. AB-LNPs showed enhanced cellular uptake efficiency compared to free BODIPY in 4T1 breast cancer cells. Under laser irradiation, AB-LNPs exhibited synergistic photothermal effects with significantly reduced dosage compared to monotherapy (treatments with Au-LNPs or free BODIPY alone). This study thus provides a facile and adaptive strategy for the development of a scalable and safe high-performance nanoplatform for synergistic PTT in the treatment of cancer and other diseases.

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Gold Nanoparticles as a Tool to Detect Biomarkers in Osteoarthritis: New Insights

Mourya,

Arya,

Singh

et al. 2024

Indian J Microbiol

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Development of X-ray contrast agents using single nanometer-sized gold nanoparticles and lactoferrin complex and their application in vascular imaging

Cited by 11 publications

References 22 publications

Monodisperse Gold Nanoparticles: A Review on Synthesis and Their Application in Modern Medicine

Monodisperse Gold Nanoparticles: A Review on Synthesis and Their Application in Modern Medicine

Facile preparation of Au- and BODIPY-grafted lipid nanoparticles for synergized photothermal therapy

Gold Nanoparticles as a Tool to Detect Biomarkers in Osteoarthritis: New Insights

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