Effects of betaine on non-alcoholic liver disease

Chen, Weiqiang; Xu, Minjuan; Xu, Minwen; Wang, Yucai; Qing-yan, Zou; Wang, Liefeng

doi:10.1017/s0954422421000056

Cited by 24 publications

(9 citation statements)

References 120 publications

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“…Studies have shown that the lack of betaine contributes to the progression of NAFLD and can interfere with NAFLD through the AMPK signalling pathway, but the specific mechanism remains to be further explored. 16 Nicotinic acid is a compound that has been promoted in clinical practice, and its anti-NAFLD mechanism may be related to inhibiting DGAT2, affecting fatty acid synthesis, and reducing hepatic oxidative stress. 17 Gallic acid is thought to exert anti-NAFLD effects by Food & Function Paper improving glucose and lipid metabolism and the health of the gut microbiota and inhibiting lipid accumulation by interfering with the AMPK signalling pathway.…”

Section: Discussionmentioning

confidence: 99%

A UPLC-Q-TOF/MS and network pharmacology method to explore the mechanism of Anhua fuzhuan tea intervention in nonalcoholic fatty liver disease

Tian

Tang

et al. 2023

Food Funct.

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Section: Discussionmentioning

confidence: 99%

A UPLC-Q-TOF/MS and network pharmacology method to explore the mechanism of Anhua fuzhuan tea intervention in nonalcoholic fatty liver disease

Tian

Tang

et al. 2023

Food Funct.

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“…Given that phosphatidylcholine is required for VLDL synthesis/secretion, part of the pathogenesis of NAFLD is expected to be related to liver choline depletion (31). Several studies have shown the effectiveness of betaine on fatty liver (32)(33)(34)(35). Although choline can also be affected by the betaine pathway because it can be converted into betaine by the oxidation of choline, it can also have a positive effect on increasing the production of VLDL and helping to exporting TG from the liver through the phosphatidylcholine pathway.…”

Section: Discussionmentioning

confidence: 99%

Effect of Citicoline on liver fat content in mice fed a high-fat diet, an experimental study

Sharifi

Jarvand

Ghasemi

2023

Preprint

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Citicoline may have a beneficial role in the protection of hepatocytes because of its role in reducing oxidative stress and its choline part role in the production of VLDL. Choline deficiency leads to liver fat accumulation, which is treated by supplying choline. The purpose of this study was to investigate the hypothesis, of whether the administration of citicoline, the precursor of choline, in mice on a high-fat diet is effective in reducing the amounts of liver fat content. Twenty-four male C57BL/6 mice, after 2 weeks on a high-fat (HF) diet, were randomly assigned to the 4 groups. Control: HF diet mice without intervention, dose 1: HF diet mice with a dose of 10 mg/kg Citicoline, dose 2: HF diet mice with an amount of 20 mg/kg citicoline, and dose 3: HF diet mice with an amount of 30 mg/kg Citicoline. After 8 weeks, the mice’s body weights, liver weights, liver dry weights, and liver fat percentages were measured. All the aspects of ARRIVE and PREPARE guidelines were considered. The differences in liver fat % between the control, dose 1, and dose 2 groups were not statistically meaningful (8.37 ± 0.39, 8.08 ± 0.65, 7.63 ± 0.55, and 7.34 ± 0.65 % for control, dose 1, dose 2, and dose 3 groups respectively; p for ANOVA test: 0.0381). A posthoc Tukey test showed that liver fat % was statistically different only between the control and dose 3 groups (mean diff: 1.03, 95%CI: 0.05 to 2.0). The liver total weight and liver dry weight were not different between the groups (p= 0.94, and p= 0.66 respectively). The intervention did not affect the mice's body weights. It seems that citicoline can be considered as a dietary supplement in the treatment of fatty liver. RCT studies are suggested to test this hypothesis.

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“…BHMT and GNMT are key proteins in the metabolism of betaine to glycine, and downregulation results in increased levels of betaine. Betaine has been shown to reduce liver fat accumulation in rats, improve insulin resistance, and reduce hepatic steatosis ( 53 ). The intervention of MSS may regulate pyruvate metabolism by limiting PCK1, a key enzyme in the process of pyruvate metabolism, and limit the process of gluconeogenesis, while increasing the amount of betaine in the liver, improving the metabolism in the liver of rats fed with the high-fat diet.…”

Section: Discussionmentioning

confidence: 99%

Integrative proteomics and metabolomics of Guizhou Miao Sour Soup affecting simple obese rats

et al. 2022

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Miao Sour Soup (MSS) is a fermented product from the Qiandongnan region of Guizhou Province, which enrich many beneficial ingredients and is widely consumed in the whole China. Fermented food is beneficial to physical health with the potential positive regulating affection on simple obesity. In this study, we analyzed the mechanism of action of MSS to prevent simple obesity induced by high-fat diet by proteomics and metabolomics. Quantitative proteomics with tandem mass tagging labeling and liquid chromatography-mass spectrometry was used to analyze the changes of liver proteins and metabolites after the MSS intervention. MSS intervention upregulated 33 proteins and 9 metabolites and downregulated 19 proteins and 10 metabolites. Bioinformatics analysis showed that MSS could prevent simple obesity by acting on the PPAR signaling pathway, retinol metabolism, fatty acid β-oxidation, fatty acid degradation, fatty acid biosynthesis, glycine, serine and threonine metabolism, pyruvate metabolism, citrate cycle (TCA cycle) and other signaling pathways. This study provides new insights into the use of MSS to prevent simple obesity caused by high-fat diets and the search for healthy eating patterns with MSS.

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Effects of betaine on non-alcoholic liver disease

Cited by 24 publications

References 120 publications

A UPLC-Q-TOF/MS and network pharmacology method to explore the mechanism of Anhua fuzhuan tea intervention in nonalcoholic fatty liver disease

A UPLC-Q-TOF/MS and network pharmacology method to explore the mechanism of Anhua fuzhuan tea intervention in nonalcoholic fatty liver disease

Effect of Citicoline on liver fat content in mice fed a high-fat diet, an experimental study

Integrative proteomics and metabolomics of Guizhou Miao Sour Soup affecting simple obese rats

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