Silk Fibroin Coated Magnesium Oxide Nanospheres: A Biocompatible and Biodegradable Tool for Noninvasive Bioimaging Applications

Li, Jitao; Khalid, Asma; Verma, R. K.; Abraham, Amanda N.; Qazi, Farah; Dong, Xiuxiu; Liang, Guozheng; Tomljenovic‐Hanic, Snjezana

doi:10.3390/nano11030695

Cited by 25 publications

(29 citation statements)

References 37 publications

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“…Certain factors are crucial in the synthesis of NPs for bioimaging applications. The primary requirement is the synthesis of optical core encapsulating the fluorochrome [ 46 , 47 , 48 , 49 ]. To improve the photostability and for the protection of the optical core, a shell is synthesized.…”

Section: Nanoparticles In Molecular Imagingmentioning

confidence: 99%

Recent Advances in Gadolinium Based Contrast Agents for Bioimaging Applications

et al. 2021

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Gadolinium (Gd) based contrast agents (CAs) (Gd-CAs) represent one of the most advanced developments in the application of Gd for magnetic resonance imaging (MRI). Current challenges with existing CAs generated an urgent requirement to develop multimodal CAs with good biocompatibility, low toxicity, and prolonged circulation time. This review discussed the Gd-CAs used in bioimaging applications, addressing their advantages and limitations. Future research is required to establish the safety, efficacy and theragnostic capabilities of Gd-CAs. Nevertheless, these Gd-CAs offer extraordinary potential as imaging CAs and promise to benefit bioimaging applications significantly.

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Section: Nanoparticles In Molecular Imagingmentioning

confidence: 99%

Recent Advances in Gadolinium Based Contrast Agents for Bioimaging Applications

et al. 2021

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“…environment at prescribed times and at controlled rates (Figure 9a) [122]. Li et al fabricated silk fi broin-coated magnesium oxide nanospheres for noninvasive bioimaging applications (Figure 9b) [123]. The biocompatibility of waveguide material is important when it needs to interface directly with living cells in biomedical applications.…”

Section: Optical Applicationsmentioning

confidence: 99%

Review on Fabrication and Application of Regenerated Bombyx mori Silk Fibroin Materials

Wang

Zhou

et al. 2023

AUTEX Research Journal

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Natural silk fiber derived from the Bombyx mori (B. mori) silkworm has long been used as a luxury raw material in textile industry because of its shimmering appearance and durability, and as surgical suture for its high strength and flexibility. Regenerated silk fibroin, as the main protein extracted from the cocoons of the B. mori silkworm, recently has gained considerable attention due to its outstanding properties, including facile processability, superior biocompatibility, controllable biodegradation, and versatile functionalization. Tremendous effort has been made to fabricate silk fibroin into various promising materials with controlled structural and functional characteristics for advanced utilities in a multitude of biomedical applications, flexible optics, electronics devices, and filtration systems. Herein, reverse engineered silk fibroin extraction methods are reviewed, recent advances in extraction techniques are discussed. Fabrication methods of silk fibroin materials in various formats are also addressed in detail; in particular, progress in new fabrication technologies is presented. Attractive applications of silk fibroin-based materials are then summarized and highlighted. The challenges faced by current approaches in production of silk fibroin-based materials and future directions acquired for pushing these favorable materials further toward above mentioned applications are further elaborated.

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“…The fluorescence properties of MgO NPs studied by Li et al using two-dimensional confocal maps at a 532 nm excitation with a green laser are shown in Figure 21 a [ 224 ]. The scale bar on the right side of Figure 21 a represents the counts (0–1 M counts per second).…”

Section: Magnesium Oxide Nanostructurementioning

confidence: 99%

Microenvironmental Behaviour of Nanotheranostic Systems for Controlled Oxidative Stress and Cancer Treatment

et al. 2022

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The development of smart, efficient and multifunctional material systems for diseases treatment are imperative to meet current and future health challenges. Nanomaterials with theranostic properties have offered a cost effective and efficient solution for disease treatment, particularly, metal/oxide based nanotheranostic systems already offering therapeutic and imaging capabilities for cancer treatment. Nanoparticles can selectively generate/scavenge ROS through intrinsic or external stimuli to augment/diminish oxidative stress. An efficient treatment requires higher oxidative stress/toxicity in malignant disease, with a minimal level in surrounding normal cells. The size, shape and surface properties of nanoparticles are critical parameters for achieving a theranostic function in the microenvironment. In the last decade, different strategies for the synthesis of biocompatible theranostic nanostructures have been introduced. The exhibition of therapeutics properties such as selective reactive oxygen species (ROS) scavenging, hyperthermia, antibacterial, antiviral, and imaging capabilities such as MRI, CT and fluorescence activity have been reported in a variety of developed nanosystems to combat cancer, neurodegenerative and emerging infectious diseases. In this review article, theranostic in vitro behaviour in relation to the size, shape and synthesis methods of widely researched and developed nanosystems (Au, Ag, MnOx, iron oxide, maghemite quantum flakes, La2O3−x, TaOx, cerium nanodots, ITO, MgO1−x) are presented. In particular, ROS-based properties of the nanostructures in the microenvironment for cancer therapy are discussed. The provided overview of the biological behaviour of reported metal-based nanostructures will help to conceptualise novel designs and synthesis strategies for the development of advanced nanotheranostic systems.

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Silk Fibroin Coated Magnesium Oxide Nanospheres: A Biocompatible and Biodegradable Tool for Noninvasive Bioimaging Applications

Cited by 25 publications

References 37 publications

Recent Advances in Gadolinium Based Contrast Agents for Bioimaging Applications

Recent Advances in Gadolinium Based Contrast Agents for Bioimaging Applications

Review on Fabrication and Application of Regenerated Bombyx mori Silk Fibroin Materials

Microenvironmental Behaviour of Nanotheranostic Systems for Controlled Oxidative Stress and Cancer Treatment

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