Recent Advances in Gadolinium Based Contrast Agents for Bioimaging Applications

Fatima, Atiya; Ahmad, Wasi Uddin; Saidi, Abdullah Khamis Ali Al; Choudhury, Arup; Chang, Yongmin; Lee, Gang Ho

doi:10.3390/nano11092449

Cited by 48 publications

(25 citation statements)

References 163 publications

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“…Magnetic resonance imaging (MRI) is one of the commonly used clinical diagnostic tools which produces multiplanar and true 3D cross section images of the region of interest in a patient’s body [ 106–108 ]. The technique primarily relies on the water present inside the body, in and around the tissues and organs to produce a contrasted image of a cross-section of that particular organ/tissue [ 109 ].…”

Section: Mri-guided Theranosticsmentioning

confidence: 99%

Challenges and opportunities in the development of metal-based anticancer theranostic agents

2022

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Around 10 million fatalities were recorded worldwide in 2020 due to cancer and statistical projections estimate the number to increase by 60 % in 2040. With such a substantial rise in the global cancer burden, the disease will continue to impose a huge socio-economic burden on society. Currently, the most widely used clinical treatment modality is cytotoxic chemotherapy using platinum drugs which is used to treat variety of cancers. Despite its clinical success, critical challenges like resistance, off-target side effects and cancer variability often reduce its overall therapeutic efficiency. These challenges require faster diagnosis, simultaneous therapy and a more personalized approach towards cancer management. To this end, small-molecule ‘theranostic’ agents have presented a viable solution combining diagnosis and therapy into a single platform. In this review we present a summary of recent efforts in the design and optimization of metal-based small-molecule ‘theranostic’ anticancer agents. Importantly, we highlight the advantages of a theranostic candidate over the purely therapeutic or diagnostic agent in terms of evaluation of their biological properties.

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Section: Mri-guided Theranosticsmentioning

confidence: 99%

Challenges and opportunities in the development of metal-based anticancer theranostic agents

2022

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“…66 Multiple varieties of gadolinium-based nanoparticles have been developed with different functionalities such as enhanced targeting and retention at the target site, better clearance, and higher signal. 67 Apart from gadolinium, other ions such as Mn 2+ and Fe 3+ have also been used as T1 contrast agents. 68,69 Ferromagnetic or superparamagnetic iron-oxide-based nanoparticles have been used as T2 MRI contrast agents for over three decades.…”

Section: Mri Imagingmentioning

confidence: 99%

Nanoparticles as Contrast Agents for Preclinical and Clinical Bioimaging

Ban¹

2022

Preprint

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Visualization of deep biological structures in human and animal bodies is not possible through the naked eye due to the scattering of visible light by tissues in tolerable intensities. Different types of imaging modalities based on electromagnetic and pressure waves have been developed that help us image deep biological tissues with varying resolution and contrast. Some of the most widely used modalities are X-ray imaging, ultrasound imaging, MRI imaging, fluorescence imaging, and photoacoustic imaging. Although these techniques have significantly helped the advancement of our understanding of deep biological tissues and functions, they often require the use of exogenous contrast agents to improve their image quality for better investigation. Nanoparticle-based contrast agents have captivated scientists because of multiple advantages associated with them such as their excellent photophysical and chemical properties, ability to be precisely delivered at the target, and superlative tunability. This article is aimed to give a brief outlook on the recent state of art advances in the usage of nanoparticles for preclinical and clinical bioimaging through fluorescence, photoacoustic, and MRI imaging modalities.

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“… 28 In particular, gadolinium (Gd)-based contrast agents have attracted substantial attention as T1-weighted MRI contrast agents and have been widely used in clinical practice. 29 In addition to traditional MRI, photoacoustic imaging (PA), as a rapidly evolving imaging technology, has great application potential in biomedical field due to its high contrast and high spatial resolution. 30 At the same time, the development of nanotechnology has made a significant contribution to the development of nanoparticle-based contrast agents for PA imaging.…”

Section: Introductionmentioning

confidence: 99%

PAI/MRI Visualization of Tumor Derived Cellular Microvesicles with Endogenous Biopolymer Nanoparticles Modification

Lv¹,

Sun²,

Guo³

et al. 2022

IJN

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Background Tumor derived cellular microvesicles (TDMVs), as excellent drug delivery vehicles in vivo, play an important role in the treatment of cancers. However, it is difficult to obtain intuitional biodistribution behavior and internalization mechanisms of TDMVs in vivo. Thus, it is very urgent and important to establish a stable and reliable visualization technology to track the biological behavior and function of TDMVs. As an endogenous biopolymer, melanin possesses natural biocompatibility and biodegradability, and various biological imaging could be realized by modifying it. Therefore, melanin-based nanoparticles are excellent candidates for in vivo visualization of TDMVs. Methods In this work, the biodistribution and metabolic behavior of TDMVs were visualized by dual-modality imaging with PAI and MRI after incubation with gadolinium ion-chelated melanin nanoparticles. Results In this study, MRI and PAI dual-modality imaging of the in vivo distribution behavior of TDMVs was achieved with the help of MNP-Gd. The good targeting ability of TDMVs at the homologous tumor site was observed, and their distribution and metabolism behavior in the whole body were studied at the meantime. The results indicated that TDMVs preferentially accumulated in syngeneic tumor sites and liver regions after intravenous injection and were eventually metabolized by the kidneys over time. Conclusion This work proposed a novel dual-modal imaging strategy for the visualization of TDMVs, which is of great significance for further understanding the biological mechanisms of extracellular vesicles.

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Recent Advances in Gadolinium Based Contrast Agents for Bioimaging Applications

Cited by 48 publications

References 163 publications

Challenges and opportunities in the development of metal-based anticancer theranostic agents

Challenges and opportunities in the development of metal-based anticancer theranostic agents

Nanoparticles as Contrast Agents for Preclinical and Clinical Bioimaging

PAI/MRI Visualization of Tumor Derived Cellular Microvesicles with Endogenous Biopolymer Nanoparticles Modification

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