Maternal blood metal concentrations and whole blood DNA methylation during pregnancy in the Early Autism Risk Longitudinal Investigation (EARLI)

Aung, Max T.; Bakulski, Kelly M.; Feinberg, Jason I.; Dou, John; Meeker, John D.; Mukherjee, Bhramar; Loch‐Caruso, Rita; Ladd‐Acosta, Christine; Volk, Heather E.; Croen, Lisa; Hertz‐Picciotto, Irva; Newschaffer, Craig J.; Fallin, Daniele

doi:10.1080/15592294.2021.1897059

Cited by 16 publications

(10 citation statements)

References 59 publications

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“…Trace metals exposure also affected fetal gene methylation levels. Cadmium (Cd), lead (Pb), total mercury (Hg), manganese (Mn) and selenium (Se) were associated with CpG sites (Aung et al, 2021). Especially, Pd was associated with CYP24A1 (cg01243877) ( P < .001) and arsenic (As) was associated with CYP2A4 and CYP7B1 (Waalkes et al, 2004).…”

Section: Resultsmentioning

confidence: 99%

Impact of individual factors on DNA methylation of drug metabolism genes: A systematic review

Bian

Zhao

et al. 2023

Environ and Mol Mutagen

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Individual differences in drug response have always existed in clinical treatment. Many non‐genetic factors show non‐negligible impacts on personalized medicine. Emerging studies have demonstrated epigenetic could connect non‐genetic factors and individual treatment differences. We used systematic retrieval methods and reviewed studies that showed individual factors' impact on DNA methylation of drug metabolism genes. In total, 68 studies were included, and half(n = 36) were cohort studies. Six aspects of individual factors were summarized from the perspective of personalized medicine: parental exposure, environmental pollutants exposure, obesity and diet, drugs, gender and others. The most research (n = 11) focused on ABCG1 methylation. The majority of studies showed non‐genetic factors could result in a significant DNA methylation alteration in drug metabolism genes, which subsequently affects the pharmacokinetic processes. However, the underlying mechanism remained unknown. Finally, some viewpoints were presented for future research.This article is protected by copyright. All rights reserved.

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Section: Resultsmentioning

confidence: 99%

Impact of individual factors on DNA methylation of drug metabolism genes: A systematic review

Bian

Zhao

et al. 2023

Environ and Mol Mutagen

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“…Several sample‐ and probe‐level quality control (QC) measures were applied (Aung et al, 2021). Samples were excluded if they were duplicates, had low overall array intensity, or a discrepancy between reported sex and empirically predicted sex.…”

Section: Methodsmentioning

confidence: 99%

Associations between accelerated parental biologic age, autism spectrum disorder, social traits, and developmental and cognitive outcomes in their children

et al. 2022

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Our findings suggest epigenetic aging could play a role in parental age risks on child brain development. Lay SummaryParental age is a risk factor for ASD; however, little is known about possible biologic aging changes that contribute to this association. We found that mothers with faster epigenetic aging and fathers with slower epigenetic aging, relative to their chronologic age, were at increased odds of having a child with ASD and/or decreased early learning, at 3 years of age. These findings suggest epigenetic aging in parents may play a role in neurodevelopment and ASD.

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“…176 Blood Pb levels were measured at 12–27 (+6) weeks gestation by AAS. Aung et al 177 reported on a novel epigenome study that identified correlations between maternal metal levels (Mn and Pb) and DNA hypermethylation at sites involved in immune responses and nervous system development. Blood Cd, Hg, Mn, Pb and Se were measured by ICP-MS and DNA methylation analysed on the Illumina 450 K array for 97 women in the Early Autism Risk Longitudinal Investigation.…”

Section: Applications: Clinical and Biological Materialsmentioning

confidence: 99%

Atomic spectrometry update: review of advances in the analysis of clinical and biological materials, foods and beverages

Patriarca

Barlow

Cross³

et al. 2022

J. Anal. At. Spectrom.

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Maternal blood metal concentrations and whole blood DNA methylation during pregnancy in the Early Autism Risk Longitudinal Investigation (EARLI)

Abstract: doi: medRxiv preprint NOTE: This preprint reports new research that has not been certified by peer review and should not be used to guide clinical practice.

Cited by 16 publications

References 59 publications

Impact of individual factors on DNA methylation of drug metabolism genes: A systematic review

Impact of individual factors on DNA methylation of drug metabolism genes: A systematic review

Associations between accelerated parental biologic age, autism spectrum disorder, social traits, and developmental and cognitive outcomes in their children

Atomic spectrometry update: review of advances in the analysis of clinical and biological materials, foods and beverages

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