Abstract:Individual differences in drug response have always existed in clinical treatment. Many non‐genetic factors show non‐negligible impacts on personalized medicine. Emerging studies have demonstrated epigenetic could connect non‐genetic factors and individual treatment differences. We used systematic retrieval methods and reviewed studies that showed individual factors' impact on DNA methylation of drug metabolism genes. In total, 68 studies were included, and half(n = 36) were cohort studies. Six aspects of indi… Show more
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