Industry 4.0 for pharmaceutical manufacturing: Preparing for the smart factories of the future

Arden, Nilou; Fisher, Adam C.; Tyner, Katherine M.; Yu, Lawrence X.; Lee, Sau L.; Kopcha, Michael

doi:10.1016/j.ijpharm.2021.120554

Cited by 180 publications

(169 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The literature lacks some research on the implementation of Industry 4.0 technologies in the plastic and petrochemical industries. Arden et al [67] presented a vision of pharmaceutical manufacturing in the future as well as some regulatory, technical, and logistical challenges that must be overcome for society to fully benefit from Industry 4.0. According to the findings, the implementation of Industry 4.0 technologies has the potential to significantly improve the flexibility, efficiency, agility, and quality of pharmaceutical manufacturing.…”

Section: Cloud Computing (Cc)mentioning

confidence: 99%

Impact of Industry 4.0 and Lean Manufacturing on the Sustainability Performance of Plastic and Petrochemical Organizations in Saudi Arabia

et al. 2021

View full text Add to dashboard Cite

Plastic and petrochemical industries are lagging behind in terms of environmental sustainability performance because of the nature of these industries. Although plastic and petrochemical industries have adopted lean manufacturing and/or Industry 4.0 technologies, more efforts are needed to enhance sustainable development. The purpose of this study is to explore the integrated impact of Industry 4.0 technologies and lean manufacturing on the sustainability performance of plastic and petrochemical industries in Saudi Arabia. Moreover, it investigates the casual relationship between Industry 4.0 technologies and sustainability performance as well as the direct linkage between Industry 4.0 and lean manufacturing. A questionnaire is used as the primary instrument for collecting data from 112 plastic and petrochemical organizations. A hypothesized relationship is formulated and then analyzed using the structural equation modeling (SEM) approach. The outcome of the analysis shows that Industry 4.0 and lean manufacturing have a positive impact on sustainability performance. The study also presents a list of valid constructs for Industry 4.0 technologies, lean manufacturing, and sustainability performance. Furthermore, the study shows that the plastic and petrochemical industries in Saudi Arabia acknowledge and recognize the contribution of Industry 4.0 technologies and lean manufacturing principles to the protection of the environment as a dimension of sustainability performance.

show abstract

Section: Cloud Computing (Cc)mentioning

confidence: 99%

Impact of Industry 4.0 and Lean Manufacturing on the Sustainability Performance of Plastic and Petrochemical Organizations in Saudi Arabia

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Both 3DP and ML are enabling features of the fourth industrial revolution, Industry 4.0, whereby traditional manufacturing methods are advanced and automated [179]. Despite both technologies existing for decades, it was only recently that the two began to merge (Figure 9).…”

Section: Applications Of ML In Pharmaceutical 3d Printingmentioning

confidence: 99%

Harnessing artificial intelligence for the next generation of 3D printed medicines

Elbadawi

McCoubrey

Gavins

et al. 2021

Advanced Drug Delivery Reviews

101

View full text Add to dashboard Cite

This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

show abstract

“…In this sector as well, digitization increases efficiency. It comes with full compliance as standard and allows you to update or improve your processes without having to revalidate them, saving your time and money ( Arden et al, 2021 ).…”

Section: The Digitization Process In Contract Development Manufacturing Organizations (Cdmo)mentioning

confidence: 99%

Digitalization in pharmaceutical industry: What to focus on under the digital implementation process?

Hole

Hole²,

McFalone-Shaw

2021

International Journal of Pharmaceutics: X

View full text Add to dashboard Cite

Digitalization of any manufacture industry is a key step in any progress of the production process. The process of digitalization includes both increased use of robotics, automatization solutions and computerization, thereby allowing to reduce costs, to improve efficiency and productivity, and to be flexible to changes. Pharmaceutical Industry (PI) has however been resistant to digitalization, mainly due to fair experience and complexity of the entailed development and manufacture processes. Nevertheless, there is a clear need to digitalize PI as the demand in both traditional and new drugs is constantly growing. Contract Development Manufacture Organizations (CDMOs) have a special digitalizing challenge. Digitalization of PI, and CDMO precisely, should be tightly related to the main aspects of Good Manufacture Practice (GMP), and, to succeed in PI digitalizing requires constant focus on GMP. Close collaboration with constantly changing stakeholders is another important factor which should be in focus during digitalization of CDMO. This paper represents an overview over the main aspects of CDMO digitalization and discusses both the opportunities and challenges of the process, focusing on the practical solutions for successive digital implementation.

show abstract

Industry 4.0 for pharmaceutical manufacturing: Preparing for the smart factories of the future

Cited by 180 publications

References 19 publications

Impact of Industry 4.0 and Lean Manufacturing on the Sustainability Performance of Plastic and Petrochemical Organizations in Saudi Arabia

Impact of Industry 4.0 and Lean Manufacturing on the Sustainability Performance of Plastic and Petrochemical Organizations in Saudi Arabia

Harnessing artificial intelligence for the next generation of 3D printed medicines

Digitalization in pharmaceutical industry: What to focus on under the digital implementation process?

Contact Info

Product

Resources

About