Synthesis of silver nanoparticles using
            <i>Ziziphus nummularia</i>
            leaf extract and evaluation of their antimicrobial, antioxidant, cytotoxic and genotoxic potential (4-in-1 system)

Padalia, Hemali; Chanda, Sumitra

doi:10.1080/21691401.2021.1903478

Cited by 18 publications

(13 citation statements)

References 36 publications

(36 reference statements)

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“…These silver nanoparticles exhibited efficient anti-microbial commotion against S. aureus, C. rubrum, S. typhimurium, P. aeruginosa, C. neoformans, C. albicans, and C. glabrata. Silver nanoparticles also exhibited good DPPH activity (IC 50 = 520 mg/mL) and ABTS activity (IC 50 = 55 mg/mL) [201]. A previous study confirmed for first time the capability of Otostegia persica for the bio-synthesis of silver nanoparticles.…”

Section: Synthesis Of Silver Nanoparticles Using Leaf Extracts: (2019-2020)mentioning

confidence: 52%

Green Synthesis of Metal and Metal Oxide Nanoparticles Using Different Plants’ Parts for Antimicrobial Activity and Anticancer Activity: A Review Article

et al. 2021

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Nanotechnology emerged as a scientific innovation in the 21st century. Metallic nanoparticles (metal or metal oxide nanoparticles) have attained remarkable popularity due to their interesting biological, physical, chemical, magnetic, and optical properties. Metal-based nanoparticles can be prepared by utilizing different biological, physical, and chemical methods. The biological method is preferred as it provides a green, simple, facile, ecofriendly, rapid, and cost-effective route for the green synthesis of nanoparticles. Plants have complex phytochemical constituents such as carbohydrates, amino acids, phenolics, flavonoids, terpenoids, and proteins, which can behave as reducing and stabilizing agents. However, the mechanism of green synthesis by using plants is still highly debatable. In this report, we summarized basic principles or mechanisms of green synthesis especially for metal or metal oxide (i.e., ZnO, Au, Ag, and TiO2, Fe, Fe2O3, Cu, CuO, Co) nanoparticles. Finally, we explored the medical applications of plant-based nanoparticles in terms of antibacterial, antifungal, and anticancer activity.

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Section: Synthesis Of Silver Nanoparticles Using Leaf Extracts: (2019-2020)mentioning

confidence: 52%

Green Synthesis of Metal and Metal Oxide Nanoparticles Using Different Plants’ Parts for Antimicrobial Activity and Anticancer Activity: A Review Article

et al. 2021

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“…Song et al [219] prepared multifunctional silver-embedded magnetic NPs; the silicaencapsulated magnetic NPs produce surface-enhanced solid Raman scattering signals to target breast cancer cells and floating leukemia cells [220]. A study showed developed carrier molecules such as chitosan to deliver silver to the cancer cells rather than using AgNPs directly.…”

Section: Anticancer Activity Of Agnpsmentioning

confidence: 99%

A Review on Silver Nanoparticles: Classification, Various Methods of Synthesis, and Their Potential Roles in Biomedical Applications and Water Treatment

Zahoor

Nazir

Iftikhar

et al. 2021

Water

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Recent developments in nanoscience have appreciably modified how diseases are prevented, diagnosed, and treated. Metal nanoparticles, specifically silver nanoparticles (AgNPs), are widely used in bioscience. From time to time, various synthetic methods for the synthesis of AgNPs are reported, i.e., physical, chemical, and photochemical ones. However, among these, most are expensive and not eco-friendly. The physicochemical parameters such as temperature, use of a dispersing agent, surfactant, and others greatly influence the quality and quantity of the synthesized NPs and ultimately affect the material’s properties. Scientists worldwide are trying to synthesize NPs and are devising methods that are easy to apply, eco-friendly, and economical. Among such strategies is the biogenic method, where plants are used as the source of reducing and capping agents. In this review, we intend to debate different strategies of AgNP synthesis. Although, different preparation strategies are in use to synthesize AgNPs such as electron irradiation, optical device ablation, chemical reduction, organic procedures, and photochemical methods. However, biogenic processes are preferably used, as they are environment-friendly and economical. The review covers a comprehensive discussion on the biological activities of AgNPs, such as antimicrobial, anticancer anti-inflammatory, and anti-angiogenic potentials of AgNPs. The use of AgNPs in water treatment and disinfection has also been discussed in detail.

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“…This increases the potential activity of the nanoparticles. [97]; Padalia, H. and Chanda, S., 2021 [98]; Padalia, H. and Chanda, S., 2021 [96], Khan et al, 2016 [94]; Parmar and Jangir, 2017 [95].…”

Section: Other Activitiesmentioning

confidence: 98%

“…Not only has green synthesis given more stable nanoparticles compared to other methods, but also it has been scalable and eco-friendly without any requirement for high temperatures and pressure or the use of toxic chemicals. So far, Ziziphus nummularia leaf extracts have been used in the green synthesis of silver [6,[94][95][96], gold [95], and zinc nanoparticles [97] (Figure 3). Indeed, during the formation of nanoparticles, the extract of Z. nummalaria functions as a reducing and stabilizing agent [96].…”

Section: Other Activitiesmentioning

confidence: 99%

“…So far, Ziziphus nummularia leaf extracts have been used in the green synthesis of silver [6,[94][95][96], gold [95], and zinc nanoparticles [97] (Figure 3). Indeed, during the formation of nanoparticles, the extract of Z. nummalaria functions as a reducing and stabilizing agent [96]. This increases the potential activity of the nanoparticles.…”

Section: Other Activitiesmentioning

confidence: 99%

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Ziziphus nummularia: A Comprehensive Review of Its Phytochemical Constituents and Pharmacological Properties

et al. 2022

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Ziziphus nummularia, a small bush of the Rhamnaceae family, has been widely used in traditional folk medicine, is rich in bioactive molecules, and has many reported pharmacological and therapeutic properties. Objective: To gather the current knowledge related to the medicinal characteristics of Z. nummularia. Specifically, its phytochemical contents and pharmacological activities in the treatment of various diseases such as cancer, diabetes, and cardiovascular diseases, are discussed. Methods: Major scientific literature databases, including PubMed, Scopus, ScienceDirect, SciFinder, Chemical Abstracts, Medicinal and Aromatic Plants Abstracts, Henriette′s Herbal Homepage, Dr. Duke′s Phytochemical and Ethnobotanical Databases, were searched to retrieve articles related to the review subject. General web searches using Google and Google scholar were also utilized. The search period covered articles published between 1980 and the end of October 2021.The search used the keywords ‘Ziziphus nummularia’, AND (‘phytochemical content’, ‘pharmacological properties, or activities, or effects, or roles’, ‘anti-inflammatory’, ‘anti-drought’, ‘anti-thermal’, ‘anthelmintic’, ‘antidiabetic’,’ anticancer’, ‘anticholinesterase’, ‘antimicrobial’, ‘sedative’, ‘antipyretic’, ‘analgesic’, or ‘gastrointestinal’). Results: This plant is rich in characteristic alkaloids, especially cyclopeptide alkaloids such as nummularine-M. Other phytochemicals, including flavonoids, saponins, glycosides, tannins, and phenolic compounds, are also present. These phytochemicals are responsible for the reported pharmacological properties of Z. nummularia, including anti-inflammatory, antioxidant, antimicrobial, anthelmintic, antidiabetic, anticancer, analgesic, and gastrointestinal activities. In addition, Z. nummularia has anti-drought and anti-thermal characteristics. Conclusion: Research into the phytochemical and pharmacological properties of Z. nummularia has demonstrated that this plant is a rich source of novel bioactive compounds. So far, Z. nummularia has shown a varied pharmacological profile (antioxidant, anticancer, anti-inflammatory, and cardioprotective), warranting further research to uncover the therapeutic potential of the bioactives of this plant. Taken together, Z. nummularia may represent a new potential target for the discovery of new drug leads.

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Synthesis of silver nanoparticles using Ziziphus nummularia leaf extract and evaluation of their antimicrobial, antioxidant, cytotoxic and genotoxic potential (4-in-1 system)

Cited by 18 publications

References 36 publications

Green Synthesis of Metal and Metal Oxide Nanoparticles Using Different Plants’ Parts for Antimicrobial Activity and Anticancer Activity: A Review Article

Green Synthesis of Metal and Metal Oxide Nanoparticles Using Different Plants’ Parts for Antimicrobial Activity and Anticancer Activity: A Review Article

A Review on Silver Nanoparticles: Classification, Various Methods of Synthesis, and Their Potential Roles in Biomedical Applications and Water Treatment

Ziziphus nummularia: A Comprehensive Review of Its Phytochemical Constituents and Pharmacological Properties

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