Effects of Age, Sex, and Obesity on N-Terminal Pro B-Type Natriuretic Peptide Concentrations in the General Population

Choi, Hyo-In; Lee, Mi Yeon; Oh, Byeong Kil; Lee, Seung-Jae; Kang, Jeong Gyu; Lee, Sung Ho; Lee, Jong‐Young; Kim, Byung Jin; Kim, Bum Soo; Kang, Jin Ho; Sung, Ki‐Chul

doi:10.1253/circj.cj-20-1104

Cited by 16 publications

(9 citation statements)

References 23 publications

(15 reference statements)

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“…Our data concur with the results reported in the adult literature clearly demonstrating (after adjustment for age and sex) a negative association between BMI SDS and NT-proBNP levels [ 7 – 9 ]. We also observed significant negative associations between SDS of lipid levels (cholesterol, LDL cholesterol, and triglycerides) and NT-proBNP levels, which was more pronounced in boys.…”

Section: Discussionsupporting

confidence: 93%

“…Previous studies investigating NT-proBNP and hsTnT in children have limitations, conducted in small study populations, not encompassing all pediatric age groups, or confounded by being collected during presentation for inter-concurrent illness or surgery [ 3 – 6 ]. In adults, population-based studies showed consistently negative associations between NT-proBNP and metabolic markers, such as BMI and lipid levels [ 7 – 9 ], whereas the limited data available from pediatric cohorts have not demonstrated this correlation [ 10 , 11 ]. These divergent findings could be due to different metabolic mechanisms in childhood or secondary to a sampling error from small study participant numbers.…”

Section: Introductionmentioning

confidence: 99%

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Age-Dependent Reference Values for hs-Troponin T and NT-proBNP and Determining Factors in a Cohort of Healthy Children (The LIFE Child Study)

et al. 2022

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This study aimed to provide reliable pediatric reference values for N-terminal pro-brain natriuretic peptide (NT-proBNP) and high-sensitive Troponin T (hsTnT) obtained from a population of well children and investigate for associations with sex, pubertal status, body mass index (BMI), and serum lipid levels. We analyzed hsTnT and NT-proBNP values obtained from 4826 samples provided by 2522 children aged 0.25–18 years participating in a prospective longitudinal population-based cohort study, “LIFE child” in Leipzig, Germany (Poulain et al., Eur J Epidemiol 32:145–158, 2017). NT-proBNP values decreased throughout childhood from values over 400 ng/L at 3 months to 138 ng/L in females and 65 ng/L in males by 18 years of age. Values dropped rapidly with advancing pubertal stage. We found a strong association between lower NT-proBNP values and higher BMI or elevated serum lipids, the latter effect being more pronounced in males. For hsTnT levels, approximately half of the measurements were below the detection limit. However, 76% of those aged 3 months and 21% of those aged 6 months had values exceeding the adult cut-off limit. Females had slightly higher levels in the first 2 years of life but this was reversed during puberty. In males, there was an upward trend from pubertal stage 2 onward. We identified a positive association between hsTnT and BMI but a negative association with low-density lipoprotein (LDL) cholesterol and triglyceride levels in boys but not in girls. Based on a large number of healthy children, we have established reliable reference values for NT-proBNP and hsTnT for use in everyday clinical practice. We have also identified important associations between certain metabolic and cardiac markers.Clinical Trial Registration ClinicalTrial.gov (NCT02550236).

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Age-Dependent Reference Values for hs-Troponin T and NT-proBNP and Determining Factors in a Cohort of Healthy Children (The LIFE Child Study)

et al. 2022

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“…In the placebo group, the factor "Oxidative Stress", increased significantly (T = -2.21; p = 0.03), whereas in the active treatment group, there was no significant difference between inclusion and 48 months (T = 0.39; p = 0.70). NT-proBNP is a critical marker of the heart function, and its reference range in healthy individuals increases with increasing age after about 50 years of age [72,73]. In the present population (age 79-88), selenium supplementation was associated with reduced NT-proBNP-levels.…”

Section: Changes After Interventionmentioning

confidence: 61%

“…NT-proBNP is a critical marker of the heart function, and its reference range in healthy individuals increases with increasing age after about 50 years of age [ 72 , 73 ]. In the present population (age 79–88), selenium supplementation was associated with reduced NT-proBNP-levels.…”

Section: Resultsmentioning

confidence: 99%

Improved cardiovascular health by supplementation with selenium and coenzyme Q10: applying structural equation modelling (SEM) to clinical outcomes and biomarkers to explore underlying mechanisms in a prospective randomized double-blind placebo-controlled intervention project in Sweden

et al. 2022

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Purpose Selenium and coenzyme Q10 have synergistic antioxidant functions. In a four-year supplemental trial in elderly Swedes with a low selenium status, we found improved cardiac function, less cardiac wall tension and reduced cardiovascular mortality up to 12 years of follow-up. Here we briefly review the main results, including those from studies on biomarkers related to cardiovascular risk that were subsequently conducted. In an effort, to explain underlying mechanisms, we conducted a structured analysis of the inter-relationship between biomarkers. Methods Selenium yeast (200 µg/day) and coenzyme Q10 (200 mg/ day), or placebo was given to 443 elderly community-living persons, for 48 months. Structural Equation Modelling (SEM) was used to investigate the statistical inter-relationships between biomarkers related to inflammation, oxidative stress, insulin-like growth factor 1, expression of microRNA, fibrosis, and endothelial dysfunction and their impact on the clinical effects. The main study was registered at Clinicaltrials.gov at 30th of September 2011, and has the identifier NCT01443780. Results In addition to positive clinical effects, the intervention with selenium and coenzyme Q10 was also associated with favourable effects on biomarkers of cardiovascular risk. Using these results in the SEM model, we showed that the weights of the first-order factors inflammation and oxidative stress were high, together forming a second-order factor inflammation/oxidative stress influencing the factors, fibrosis (β = 0.74; p < 0.001) and myocardium (β = 0.65; p < 0.001). According to the model, the intervention impacted fibrosis and myocardium through these factors, resulting in improved cardiac function and reduced CV mortality. Conclusion Selenium reduced inflammation and oxidative stress. According to the SEM analysis, these effects reduced fibrosis and improved myocardial function pointing to the importance of supplementation in those low on selenium and coenzyme Q10.

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“…This new index is expected to be widely used clinically because it encompasses the advantages of both ANP and BNP as clinical indices. Furthermore, N-terminal pro BNP is regulated by various factors, 49 and the relationship between these factors and NPI should be clarified in the future. Finally, this factor is expected to be dynamic during treatment, and further research is needed to better assess at what stage of treatment it should be measured.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Value of Novel Natriuretic Peptide Index After Percutaneous Coronary Intervention

Horikoshi

Nakamura

Yamaguchi

et al. 2023

Circ J

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Natriuretic peptides not only exert physiological effects, but also act as clinical markers. ANP and BNP are powerful prognostic indicators and are widely used as clinical markers of cardiovascular disease. 2,13-16 For example, patients with higher plasma ANP concentrations after experiencing myocardial infarction (MI) have a poor long-term prognosis. 17 Also in MI, BNP is secreted in larger amounts than ANP from both the infarcted myocardium 15 and the surviving myocardium after being stimulated by ventricular wall stress. 18 Elevated natriuretic peptide levels are predictors of poor prognosis independently or with left ventricular ejection fraction (LVEF), regardless of the cause of hemodynamic compromise. 19,20 Furthermore, BNP is a predictor of poor prognosis not only in patients with various cardiovascular diseases, but also in the general population. 21 Given that ANP and BNP are powerful clinical markers, the significance of the simultaneous measurement of ANP and BNP was discussed by Ruskoaho and its usefulness pointed out: BNP reflects prolonged cardiac overload and ANP reflects acute rapid volume load or hemodynamic change by releasing ANP stored in the atrium. 22 This may

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Effects of Age, Sex, and Obesity on N-Terminal Pro B-Type Natriuretic Peptide Concentrations in the General Population

Cited by 16 publications

References 23 publications

Age-Dependent Reference Values for hs-Troponin T and NT-proBNP and Determining Factors in a Cohort of Healthy Children (The LIFE Child Study)

Age-Dependent Reference Values for hs-Troponin T and NT-proBNP and Determining Factors in a Cohort of Healthy Children (The LIFE Child Study)

Improved cardiovascular health by supplementation with selenium and coenzyme Q10: applying structural equation modelling (SEM) to clinical outcomes and biomarkers to explore underlying mechanisms in a prospective randomized double-blind placebo-controlled intervention project in Sweden

Prognostic Value of Novel Natriuretic Peptide Index After Percutaneous Coronary Intervention

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