Prognostic Value of Novel Natriuretic Peptide Index After Percutaneous Coronary Intervention

Abstract

Natriuretic peptides not only exert physiological effects, but also act as clinical markers. ANP and BNP are powerful prognostic indicators and are widely used as clinical markers of cardiovascular disease. 2,13-16 For example, patients with higher plasma ANP concentrations after experiencing myocardial infarction (MI) have a poor long-term prognosis. 17 Also in MI, BNP is secreted in larger amounts than ANP from both the infarcted myocardium 15 and the surviving myocardium after being stimulated by ventricular wall stress. 18 Elevated natriuretic peptide levels are predictors of poor prognosis independently or with left ventricular ejection fraction (LVEF), regardless of the cause of hemodynamic compromise. 19,20 Furthermore, BNP is a predictor of poor prognosis not only in patients with various cardiovascular diseases, but also in the general population. 21 Given that ANP and BNP are powerful clinical markers, the significance of the simultaneous measurement of ANP and BNP was discussed by Ruskoaho and its usefulness pointed out: BNP reflects prolonged cardiac overload and ANP reflects acute rapid volume load or hemodynamic change by releasing ANP stored in the atrium. 22 This may