Zingerone (4-(four-hydroxy-3-methylphenyl) butane-two-1) modulates adjuvant-induced rheumatoid arthritis by regulating inflammatory cytokines and antioxidants

Bashir, Nazirah; Ahmad, Sheikh Bilal; Rehman, Muneeb U.; Muzamil, Showkeen; Bhat, Rahil Razak; Mir, Manzoor Ur Rahman; Shazly, Gamal A.; Ibrahim, Mohamed; Elossaily, Gehan M.; Sherif, Abdelrahman Y.; Kazi, Mohsin

doi:10.1080/13510002.2021.1907518

Cited by 19 publications

(11 citation statements)

References 71 publications

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“…Similarly, ZIN attenuated vancomycin-induced hepatotoxicity in rats with the same mechanism [40]. ZIN also showed the antioxidant and anti-inflammatory effects in multiple disease models [41][42][43]. Nevertheless, this is the first study reporting the positive role of ZIN on the polymicrobial sepsis model.…”

Section: Discussionmentioning

confidence: 74%

Zingerone Inhibits the Neutrophil Extracellular Trap Formation and Protects against Sepsis via Nrf2-Mediated ROS Inhibition

Zhu

Wang

Luo

et al. 2022

Oxidative Medicine and Cellular Longevity

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Neutrophils release chromatin and antimicrobial proteins to trap and kill microbes, which is termed as neutrophil extracellular trap (NET) formation. NETs play a pivotal role in host defense against infection. However, emerging evidence indicated that NETs also contribute to an exaggerated inflammatory response and organic injuries in sepsis. Zingerone, a natural compound extracted from Zingiber officinale, exerts antioxidant, anti-inflammatory, and antioncogenic properties. In this study, we found that treatment with zingerone reduced organ injury and improved the outcome in a cecal ligation puncture- (CLP-) induced polymicrobial sepsis model. Administration of zingerone also alleviates reactive oxygen species (ROS) accumulation and systematic inflammation in septic mice and inhibits neutrophil extracellular traps (NETs) formation in vivo and in vitro. Furthermore, inhibition of nuclear factor erythroid 2-related factor 2 (Nrf2) with its specific antagonist significantly counteracted the suppressive effects of zingerone on ROS and NETs and retarded the protective role of zingerone against sepsis-associated organ injury. In addition, exposure to zingerone does not affect phagocytic activity of neutrophils in vitro and bacterial dissemination in vivo. Above all, our results indicate that zingerone treatment obviously attenuates NET formation and inflammatory response via Nrf2-mediated ROS inhibition, thus providing a novel therapeutic strategy against sepsis-induced injury.

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Section: Discussionmentioning

confidence: 74%

Zingerone Inhibits the Neutrophil Extracellular Trap Formation and Protects against Sepsis via Nrf2-Mediated ROS Inhibition

Zhu

Wang

Luo

et al. 2022

Oxidative Medicine and Cellular Longevity

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“…A recent document explained that oral administration of zingerone, an active constituent of ginger (25 mg/kg, 3 weeks), to adjuvant-induced RA rats considerably decreased the amounts of NF-κB, transforming growth factor-beta (TGF-β), TNF-α, IL-1β, IL-6, and high-sensitivity C-reactive protein (hs-CRP), and significantly enhanced IL-10 levels. Moreover, zingerone restored the amounts of antioxidant enzymes [50]. Cedrol, a ginger active component, has been shown to improves RA by decreasing inflammation and preventing Janus kinase 3 (JAK3) phosphorylation [51].…”

Section: Zingiber Officinale (Ginger)mentioning

confidence: 99%

Action Mechanisms of Antirheumatic Herbal Medicines

Nakisa¹

2022

Rheumatoid Arthritis

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Rheumatoid arthritis (RA) is a chronic inflammatory and debilitating joint disorder that causes severe impairment and reduces the quality of life. The available synthetic medicines used as standard therapy for RA have numerous side effects that can compromise their therapeutic outcomes. Thus, the demand for alternative and complementary medicines is increasing. A search of English articles in PubMed, Scopus, Google Scholar, and Web of Science databases was carried out on probable mechanisms of action of herbs with the antirheumatic property. Herbal medicines stated in folk medicine face acceptance concerns by the medical community because of the lack of scientific documents regarding their physio-pharmacological mechanisms. This chapter aims to review the possible antirheumatic effects of various herbs, including Rosmarinus officinalis L., Curcuma longa, and Crocus sativus, their related mechanisms, and preclinical applications, in order to recall the therapeutic properties of herbal medicine. However, more clinical trials are required to confirm the safety and efficacy of these antirheumatic herbal medicines.

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“…[24][25][26] In addition, some scholars have found that turmeric contained in Shengjiang (Rhizoma Zingiberis Recens) has good antioxidant and anti-inflammatory effects, and has a certain effect on the prevention and treatment of arthritis-related diseases. 27…”

Section: Shengjiang (Rhizoma Zingiberis Recens)mentioning

confidence: 99%

Application of Huangqi Guizhi Wuwu Decoction in Orthopaedics and Traumatology

Tan

Wang

et al. 2022

Chinese medicine and natural products

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The Huangqi Guizhi Wuwu Decoction(HQGZWWT) is composed of Huangqi (Astragali Radix), Shaoyao (Paeoniae Radix Alba), Guizhi (Cinnamomi Ramulus), Shengjiang (Zingiberis Rhizoma Recens), and Dazao (Jujubae Fructus) which has various pharmacological anti-inflammatory, analgesic, antioxidant, antitumor, lipid-lowering, and immunity-regulating activities. It has certain advantages in the treatment of orthopaedic diseases, such as cervical spondylosis, scapulohumeral periarthritis, lumbar disc herniation, knee osteoarthritis, rheumatoid arthritis, myofascial pain syndrome, etc., with outstanding clinical efficacy, few adverse reactions, and high patient compliance. However, modern pharmacological researches on the whole prescription of HQGZWWT are insufficient and the therapeutic targets are not clear which needs further exploration. Besides, this prescription cannot treat all orthopaedic diseases, so we should adhere to the thinking of four diagnostics in traditional Chinese medicine (TCM), select prescriptions based on syndrome differentiation, closely follow the pathogenesis, innovate and expand its scope of application, reflect the application advantages of this prescription in orthopaedics and traumatology and improve the total clinical efficiency.

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Zingerone (4-(four-hydroxy-3-methylphenyl) butane-two-1) modulates adjuvant-induced rheumatoid arthritis by regulating inflammatory cytokines and antioxidants

Abstract: Kazi (2021) Zingerone (4-(four-hydroxy-3-methylphenyl) butane-two-1) modulates adjuvant-induced rheumatoid arthritis by regulating inflammatory cytokines and antioxidants,

Cited by 19 publications

References 71 publications

Zingerone Inhibits the Neutrophil Extracellular Trap Formation and Protects against Sepsis via Nrf2-Mediated ROS Inhibition

Zingerone Inhibits the Neutrophil Extracellular Trap Formation and Protects against Sepsis via Nrf2-Mediated ROS Inhibition

Action Mechanisms of Antirheumatic Herbal Medicines

Application of Huangqi Guizhi Wuwu Decoction in Orthopaedics and Traumatology

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