Unraveling the riverine antibiotic resistome: The downstream fate of anthropogenic inputs

Lee, Jangwoo; Ju, Feng; Maile-Moskowitz, Ayella; Beck, Karin; Maccagnan, Andreas; McArdell, Christa S.; Molin, Marco Dal; Fenicia, Fabrizio; Vikesland, Peter J.; Pruden, Amy; Stamm, Christian; Bürgmann, Helmut

doi:10.1016/j.watres.2021.117050

Cited by 61 publications

(51 citation statements)

References 33 publications

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“…As expected, the tributaries were the overwhelming contribution of the dispersal source to the Chishui River, and the other external immigrations may have a limited dispersal to the river. This was inconsistent with the previous studies, which showed that livestock, domestic sewage discharge, and agriculture were the main contributors of river pollution ( Liu G. et al, 2018 ; Lee et al, 2021 ). This discrepancy might be explained by the Chishui River is located in a karst area, and the external immigrations cannot reach the Chishui River due to that the immigrations may infiltrate into the groundwater quickly.…”

Section: Discussioncontrasting

confidence: 97%

Deterministic processes shape bacterial community assembly in a karst river across dry and wet seasons

Zhang

Yang

et al. 2022

Front. Microbiol.

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Karst rivers are particularly vulnerable to bacterial pollution because immigrations are easily diffused from the surrounding environments due to their strong hydraulic connectivity. However, the assembly mechanism in shaping riverine bacterial biogeography is still poorly understood, especially for an ecosystem in the karst area. Here, 16S rRNA genes were used to explore the spatiotemporal and biogeographical patterns of bacterial communities from the Chishui River in the dry and wet seasons, and explore the impact of external immigration on the assembly of water bacterial communities. Our results showed clear spatiotemporal patterns of bacterial communities with a more pronounced seasonal rather than spatial fluctuation, which appeared to be dependent on seasonal-related environmental factors (e.g., temperature and turbidity). The bacterial communities exhibited a significant (p < 0.05) distance–decay pattern in both seasons, and they had a stronger distance–decay relationship in the dry season than in the wet season. However, most of the biomarkers of different external immigrations did not show significant (p > 0.05) distance–decay patterns along the Chishui river, implying that the biomarkers could be used as indicators of external immigration (e.g., OTU_125 and OTU_536). Also, the tributaries were the main external immigration (20.44–83.68%) for the Chishui River, while other terrestrial immigration (e.g., livestock, the soil of the cropland, brewing wastewater treatment plant, and sewages) showed relatively little influence, which could be due to the hydrodynamic conditions (e.g., fragile rock–soil system and hydrological structure) of the karst river. Additionally, the assembly of water bacterial communities in the Chishui river was governed by more determinism (50.7–85.7%) than stochasticity (14.3–49.3%) in both the dry and wet seasons. We demonstrated that the bacterial community’s substantial variations are largely shaped by deterministic processes, thereby providing a better understanding of spatiotemporal patterns and mechanisms of the bacterial community in karst river waters.

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Section: Discussioncontrasting

confidence: 97%

Deterministic processes shape bacterial community assembly in a karst river across dry and wet seasons

Zhang

Yang

et al. 2022

Front. Microbiol.

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“…The resistome concept has been recently developed (Bello-López et al, 2019;Lim et al, 2018), including in the case of rivers (Lee et al, 2021;Lekunberri et al, 2018). The resistome is the set of all genes (chromosomic ones responsible for innate resistance and genes acquired by genome changes, which can be inherited in a stable manner from generation to generation or via HGT) that directly or indirectly contribute to AR in the various bacteria (environmental and clinically important pathogens).…”

Section: Evaluation Of Possible Horizontal Transfer Of Resistant Genesmentioning

confidence: 99%

Antimicrobial Resistance in Rivers: A Review of the Genes Detected and New Challenges

Grenni

2022

Enviro Toxic and Chemistry

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River ecosystems are very important parts of the water cycle and an excellent habitat, food, and drinking water source for many organisms, including humans. Antibiotics are emerging contaminants which can enter rivers from various sources. Several antibiotics and their related antibiotic resistance genes (ARGs) have been detected in these ecosystems by various research programs and could constitute a substantial problem. The presence of antibiotics and other resistance cofactors can boost the development of ARGs in the chromosomes or mobile genetic elements of natural bacteria in rivers. The ARGs in environmental bacteria can also be transferred to clinically important pathogens. However, antibiotics and their resistance genes are both not currently monitored by national or international authorities responsible for controlling the quality of water bodies. For example, they are not included in the contaminant list in the European Water Framework Directive or in the US list of Water-Quality Benchmarks for Contaminants. Although ARGs are naturally present in the environment, very few studies have focused on non-impacted rivers to assess the background ARG levels in rivers, which could provide some useful indications for future environmental regulation and legislation. The present study reviews the antibiotics and associated ARGs most commonly measured and detected in rivers, including the primary analysis tools used for their assessment. In addition, other factors that could enhance antibiotic resistance, such as the effects of chemical mixtures, the effects of climate change, and the potential effects of the coronavirus disease 2019 pandemic, are discussed.

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“…Recent investigations provided strong evidence that APMs are vehicles for AMR ( 16 , 21 , 25 , 26 ), potentially aggravating bacterial pathogenesis. In addition to the environmental microbiomes of soil ( 27 , 28 ), surface water ( 29 , 30 ), urban wastewater treatment plants ( 31 , 32 ), hospitals ( 33 ), and seawater ( 34 ), antibiotic resistance determinants (ARDs) were also widespread in airborne microbiomes ( 35 , 36 ). ARDs of most of the common and last-line antibiotics, including colistin and vancomycin, have been detected in the air ( 16 ).…”

Section: Introductionmentioning

confidence: 99%

Regionalization and Shaping Factors for Microbiomes and Core Resistomes in Atmospheric Particulate Matters

Tong

et al. 2022

mSystems

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Unraveling the riverine antibiotic resistome: The downstream fate of anthropogenic inputs

Cited by 61 publications

References 33 publications

Deterministic processes shape bacterial community assembly in a karst river across dry and wet seasons

Deterministic processes shape bacterial community assembly in a karst river across dry and wet seasons

Antimicrobial Resistance in Rivers: A Review of the Genes Detected and New Challenges

Regionalization and Shaping Factors for Microbiomes and Core Resistomes in Atmospheric Particulate Matters

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