Associations of plasma PAPP-A2 and genetic variations with salt sensitivity, blood pressure changes and hypertension incidence in Chinese adults

Wang, Yang; Jia, Hao; Gao, Weihua; Zou, Ting; Shi, Yiting; Du, Ming-Fei; Zhang, Xiaoyu; Chu, Chao; Liao, Yue‐Yuan; Chen, Chen; Wang, Dan; Ma, Qiang; Hu, Jiawen; Wang, Keke; Yu, Yan; Sun, Yue; Hu, Gui-Lin; Niu, Ze-Jiaxin; Zhou, Hao-Wei; Xi, Zhiyong; Wang, Xin; Li, Chunhua; Chen, Fang-Yao; Gao, Ke; Zhang, Jie; Guan, Yongjuan; Chang, John; Yang, Tie‐Lin; Mu, Jianjun

doi:10.1097/hjh.0000000000002846

Cited by 16 publications

(38 citation statements)

References 45 publications

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“…In addition, we used the truncated product method (TPM), which combines P values from each SNP association analysis, to evaluate the overall associations of UMOD gene with longitudinal BP changes and the incidence of hypertension ( 19 , 24 , 35 ). Gene-based analysis is a method that can evaluate the association between a trait and a candidate gene, and is performed with R software (version 3.0.1; http://www.r-project.org ).…”

Section: Methodsmentioning

confidence: 99%

“…Assembled from April to November 2004, the Baoji Salt-Sensitive Study cohort consists of 514 adults from 124 families in seven villages in Baoji, Shaanxi, China. The detailed design of this study has been published previously (19)(20)(21)(22)(23)(24). To explore the associations of UMOD genetic variations with longitudinal BP changes and hypertension incidence, we followed up this cohort in 2009 and 2012.…”

Section: Incidence Of Hypertensionmentioning

confidence: 99%

“…Genomic DNA was isolated and purified from the whole blood samples by the GoldMag-Mini kits (GoldMag Co. Ltd. Xian, China). All the genotyping experiments were completed by CapitalBio (CapitalBio Corp, Beijing, China) as previously described (19)(20)(21)(22)24).…”

Section: Snp Selection and Genotypingmentioning

confidence: 99%

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Associations of Serum Uromodulin and Its Genetic Variants With Blood Pressure and Hypertension in Chinese Adults

Wang

Shi

et al. 2021

Front. Cardiovasc. Med.

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Background: Uromodulin, also named Tamm Horsfall protein, has been associated with renal function and regulation of sodium homeostasis. We aimed to examine the associations of serum uromodulin levels and its genetic variants with longitudinal blood pressure (BP) changes and hypertension incidence/risk.Methods: A total of 514 participants from the original Baoji Salt-Sensitive Study cohort were genotyped to examine the associations of genetic variations in uromodulin gene with the longitudinal BP changes and the incidence of hypertension over 8 years of follow-up. In addition, 2,210 subjects from the cohort of Hanzhong Adolescent Hypertension Study were used to investigate the relationships between serum uromodulin levels and the risk of hypertension.Results: SNPs rs12917707 and rs12708631 in the uromodulin gene were significantly associated with the longitudinal BP changes over 8 years of follow-up. SNP rs12708631 was significantly associated with the incidence of hypertension over 8 years. In addition, gene-based analyses supported the associations of uromodulin gene with the longitudinal BP changes and hypertension incidence in Baoji Salt-Sensitive Study cohort. Furthermore, serum uromodulin levels in the hypertensive subjects were lower than in the normotensive subjects (25.5 ± 1.1 vs. 34.7 ± 0.7 ng/mL). Serum uromodulin levels decreased gradually as BP levels increased (34.6, 33.2, 27.8, and 25.0 ng/mL for subjects with normotension, high-normal, grade 1 hypertension, and grade 2 hypertension, respectively). Serum uromodulin was significantly associated with the lower risk of hypertension [0.978 (0.972–0.984)] in Hanzhong Adolescent Hypertension Study cohort.Conclusion: This study shows that uromodulin is associated with blood pressure progression and development of hypertension.

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Section: Methodsmentioning

confidence: 99%

Section: Incidence Of Hypertensionmentioning

confidence: 99%

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Associations of Serum Uromodulin and Its Genetic Variants With Blood Pressure and Hypertension in Chinese Adults

Wang

Shi

et al. 2021

Front. Cardiovasc. Med.

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“…By contrast, it has been described that PAPP-A is one of the most enriching proteins of cardiac-resident progenitor cells (CPCs)’s secreted exosomes, where it might function as protective, releasing surrounding ligands including IGF-I [ 37 ]. Moreover, increased levels of PAPP-A have been associated with hypertension and hypertensive disorders [ 38 ], although the precise mechanism underlying the pathogenesis of hypertension remains poorly understood. The correlation of PAPP-A with pregnancy-induced hypertension has been extensively demonstrated [ 39 , 40 ] and PAPP-A has been proposed as a biomarker for the early diagnosis of pre-eclampsia [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

Increase in Ischemia-Modified Albumin and Pregnancy-Associated Plasma Protein-A in COVID-19 Patients

Sánchez

Gasalla

Sánchez‐Chapado

et al. 2021

JCM

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This study was undertaken due to the urgent need to explore reliable biomarkers for early SARS-CoV-2 infection. We performed a retrospective study analyzing the serum levels of the cardiovascular biomarkers IL-6, TNF-α, N-terminal pro-B natriuretic peptide, cardiac troponin T (cTnT), ischemia-modified albumin (IMA) and pregnancy-associated plasma protein-A (PAPP-A) in 84 patients with COVID-19.Patients were divided into three groups according to their RT-qPCR and IgG values: acute infection (n = 35), early infection (n = 25) or control subjects (n = 24). Levels of biomarkers were analyzed in patient serum samples using commercially available ELISA kits. Results showed a significant increase in IMA and PAPP-A levels in the early infected patients. Moreover, multivariate analysis and receiver operating characteristic (ROC) curve showed that IMA and PAPP-A had excellent discrimination value for the early stage of COVID-19. For IMA, the area under the ROC curve (AUC) had a value of 0.94 (95% confidence interval (CI): 0.881–0.999). Likewise, the serum level of PAPP-A was significantly higher in patients with early infection than in the control subjects (AUC = 0.801 (95% CI: 0.673–0.929)). The combined use of IMA and PAPP-A enhanced the sensitivity for total SARS-CoV-2-infected patients to 93%. These results suggest that the increased levels of PAPP-A and IMA shed light on underlying mechanisms of COVID-19 physiopathology and might be used as efficient biomarkers with high sensitivity and specificity for the early stage of COVID-19. Importantly, when monitoring pregnancy and cardiovascular diseases using PAPP-A or IMA levels, a SARS-CoV-2 infection should be discarded for proper interpretation of the results.

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“…In addition, we used the truncated product method (TPM), which combines P values from each SNP association analysis, to evaluate the overall associations of UMOD gene with longitudinal BP changes and the incidence of hypertension (19,24,35). Genebased analysis is a method that can evaluate the association between a trait and a candidate gene, and is performed with R software (version 3.0.1; http://www.r-project.org).…”

Section: Statistical Analysesmentioning

confidence: 99%

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Associations of plasma PAPP-A2 and genetic variations with salt sensitivity, blood pressure changes and hypertension incidence in Chinese adults

Abstract: Supplemental Digital Content is available in the text

Cited by 16 publications

References 45 publications

Associations of Serum Uromodulin and Its Genetic Variants With Blood Pressure and Hypertension in Chinese Adults

Associations of Serum Uromodulin and Its Genetic Variants With Blood Pressure and Hypertension in Chinese Adults

Increase in Ischemia-Modified Albumin and Pregnancy-Associated Plasma Protein-A in COVID-19 Patients

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