Introduction of Nanobiotechnology

Lee, Kwee-Yum; Pham, Xuan‐Hung; Rho, Won‐Yeop; Chang, Hyejin; Kim, Jaehi; Hahm, Eunil; Lee, Jong-Hun; Lee, Jun Young; Jun, Bong‐Hyun

doi:10.1007/978-981-33-6158-4_1

Cited by 6 publications

(7 citation statements)

References 20 publications

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“…Nowadays, the most frequently NMs used in nanomedicine are: 1) metal NPs and their oxides (gold, gold nanoclusters [GNCS/AuNCs], titanium, zinc, zinc oxide, thallium, platinum, silver, silica, iron oxide [IO], quantum dots [QDs], superparamagnetic iron oxide NPs [SPIONs], and upconverting NPs [UCNPs]); 2) carbon-based nanomaterials (carbon nanotubes [CNTs], fullerenes, nanodiamonds [NDs] graphene oxide [GO]); 3) organic NPs (dendrimers, ferritin, lipid-based NPs, micelles, and polymers); and 4) hybrid systems that have been created by combining organic and inorganic NPs ( Figure 3 ) ( Pelaz et al, 2017 ; Khan et al, 2018 ; Lee et al, 2021 ; Seaberg et al, 2021 ). Inorganic NPs have been employed in imaging techniques and biosensors.…”

Section: Nanomedicinementioning

confidence: 99%

“…Inorganic NPs have been employed in imaging techniques and biosensors. In contrast, NMs such as liposomes, lipid micelles, polymers, dendrimers, CNTs, CO, NDs, ribonucleic acid NPs (RNPs), and protein constructs have been used mainly in vaccines and drug delivery systems ( Anselmo and Mitragotri, 2016 ; Pelaz et al, 2017 ; Khan et al, 2018 ; Lee et al, 2021 ; Seaberg et al, 2021 ). Likewise, in the design of inorganic/organic hybrid systems, the properties of both types of molecules are considered.…”

Section: Nanomedicinementioning

confidence: 99%

“…For example, inorganic NPs like AuNPs, iron oxide NPs (IONPs), zinc oxide NPs (ZONPs), mesoporous silica NPs (MSNs), and graphene QDs (GQDs) can be photo-responsive, conductive, superparamagnetic, pH-responsive, catalytic, and photoluminescent. Similarly, organic NMs properties to be considered in the construction of hybrid systems are the response to stimuli such as pH, temperature and redox, biocompatibility, transmembrane delivery ability, cell stability, high loading function, solubility, nontoxicity, and stimuli/targeting ligands ( Lee et al, 2021 ; Seaberg et al, 2021 ). Some examples of organic nanomaterials that have been used in hybrid systems are dendrimers (poly-amidoamine [PAMAM]), polymers (poly-lactic-co-glycolic acid [PLGA], chitosan, poly-L-lysine [PLL]), liposomes, micelles, and cells membranes from white blood cells (WBCs), red blood cells (RBCs), cancer cells and mesenchymal stem cells (MSCs) ( Figure 3 ).…”

Section: Nanomedicinementioning

confidence: 99%

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Nanotechnology and Matrix Metalloproteinases in Cancer Diagnosis and Treatment

González-Ávila

Sommer²,

García-Hernández³

et al. 2022

Front. Mol. Biosci.

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Cancer is still one of the leading causes of death worldwide. This great mortality is due to its late diagnosis when the disease is already at advanced stages. Although the efforts made to develop more effective treatments, around 90% of cancer deaths are due to metastasis that confers a systemic character to the disease. Likewise, matrix metalloproteinases (MMPs) are endopeptidases that participate in all the events of the metastatic process. MMPs’ augmented concentrations and an increased enzymatic activity have been considered bad prognosis markers of the disease. Therefore, synthetic inhibitors have been created to block MMPs’ enzymatic activity. However, they have been ineffective in addition to causing considerable side effects. On the other hand, nanotechnology offers the opportunity to formulate therapeutic agents that can act directly on a target cell, avoiding side effects and improving the diagnosis, follow-up, and treatment of cancer. The goal of the present review is to discuss novel nanotechnological strategies in which MMPs are used with theranostic purposes and as therapeutic targets to control cancer progression.

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Section: Nanomedicinementioning

confidence: 99%

Section: Nanomedicinementioning

confidence: 99%

Section: Nanomedicinementioning

confidence: 99%

See 1 more Smart Citation

Nanotechnology and Matrix Metalloproteinases in Cancer Diagnosis and Treatment

González-Ávila

Sommer²,

García-Hernández³

et al. 2022

Front. Mol. Biosci.

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“…Nanotechnology has made significant contributions to the development of modern society and is currently receiving considerable attention as a result of its potential to break through current stagnation and open up new horizons for technological advancement [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 ]. Quantum dots (QDs) are one type of nanomaterial that has been studied intensively over the last 30 years, and both significant and continuous advances in their domain have been made since their introduction in the 1980s [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Application of Silica-Coated Quantum Dots in Biomedicine

Pham

Park

Ham

et al. 2021

IJMS

Self Cite

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Quantum dots (QDs) are semiconductor nanoparticles with outstanding optoelectronic properties. More specifically, QDs are highly bright and exhibit wide absorption spectra, narrow light bands, and excellent photovoltaic stability, which make them useful in bioscience and medicine, particularly for sensing, optical imaging, cell separation, and diagnosis. In general, QDs are stabilized using a hydrophobic ligand during synthesis, and thus their hydrophobic surfaces must undergo hydrophilic modification if the QDs are to be used in bioapplications. Silica-coating is one of the most effective methods for overcoming the disadvantages of QDs, owing to silica’s physicochemical stability, nontoxicity, and excellent bioavailability. This review highlights recent progress in the design, preparation, and application of silica-coated QDs and presents an overview of the major challenges and prospects of their application.

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“…Nowadays, nanomaterials are increasingly being used for disease control, as their specific physico-chemical properties allow them to more easily enter plants and interact with invasive pathogens in plants (Lee et al 2021). Silver nanoparticles (AgNPs) are the most widely explored antibacterial nano-agent due to the broadspectrum antimicrobial properties and robust inhibition on bacteria, viruses, and fungi (Zhang et al 2022).…”

mentioning

confidence: 99%

Biosynthesized silver nanoparticles inhibit Pseudomonas syringae pv. tabaci by directly destroying bacteria and inducing plant resistance in Nicotiana benthamiana

Jiang

Xiang

et al. 2022

Phytopathol Res

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Silver (Ag)-containing agents or materials are widely used today in plant protection for their antimicrobial activity. In view of the superior inhibitory ability of biosynthesized (aldehyde-modified sodium alginate based) silver nanoparticles (AgNPs) against plant pathogenic fungi in our previous research, here we explored the antagonistic effect of biosynthesized AgNPs on plant pathogenic bacteria and the underlying mechanism. We selected Pseudomonas syringae pv. tabaci, the causal agent of tobacco wildfire disease, as the target and found that 1.2 μg/mL biosynthesized AgNPs completely inhibited the growth of P. syringae pv. tabaci in vitro and in vivo by partly destroying the cell membrane structure of the pathogen, resulting in cytoplasmic leakage. Moreover, Nicotiana benthamiana treated with 1.2 μg/mL biosynthesized AgNPs exhibited a significant upregulation of nonexpressor of pathogenesis-related genes 1 (NPR1) and pathogenesis-related gene 2 (PR2), the typical markers of the salicylic acid (SA)-mediated defense system, and an increase in peroxidase (POD) and polyphenol oxidase (PPO) activities as well as the production of reactive oxygen species (ROS). Furthermore, biosynthesized AgNPs treatment increased the chlorophyll content and dry weight of N. benthamiana. Overall, we demonstrated that biosynthesized AgNPs at a low concentration have high inhibitory effect on the pathogen causing tobacco wildfire disease by destroying bacterial cell membrane and inducing defense resistance in host plant. These results lay a theoretical foundation for further application of biosynthesized AgNPs in the control of plant bacterial diseases.

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Introduction of Nanobiotechnology

Cited by 6 publications

References 20 publications

Nanotechnology and Matrix Metalloproteinases in Cancer Diagnosis and Treatment

Nanotechnology and Matrix Metalloproteinases in Cancer Diagnosis and Treatment

Synthesis and Application of Silica-Coated Quantum Dots in Biomedicine

Biosynthesized silver nanoparticles inhibit Pseudomonas syringae pv. tabaci by directly destroying bacteria and inducing plant resistance in Nicotiana benthamiana

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