Effects of combined theta burst stimulation and transcranial direct current stimulation of the dorsolateral prefrontal cortex on stress

Transcranial direct current stimulation versus intermittent theta-burst stimulation for the improvement of working memory performance

“…However, the combination of different NIBS interventions over the DLPFC has been less investigated. In this context, our findings are in line with the results of a recent study that showed no superiority of the combination tDCS-iTBS, compared to iTBS alone, over the DLPFC, on stress response ( De Smet et al, 2021 ). In turn, synergistic effects between tDCS and neurocognitive techniques ( Dedoncker et al, 2021 ) have been previously reported.…”

“…While these are promising findings, studies combining NIBS protocols in humans have focused primarily on evaluating cortical excitability, a brain outcome that is relatively easier to measure than the ones available for the DLPFC. In fact, only two trials used tDCS to precondition the DLPFC before a course of excitatory rTMS protocol for depression and stress outcomes ( De Smet et al, 2021 ; Loo et al, 2009 ), but no study investigated the cognitive findings of this combination.…”

Effects of neuromodulation on cognitive and emotional responses to psychosocial stressors in healthy humans

“…Stressor tDCS/dlPFC (left) Anodal Stress : ↑ RT and accuracy (n-back) Stress : N/A Stress : ↑ cortisol, ↑ HR, HRV, ↑ PNS activation (LF power ↓ & HF power ↑) No interaction effect (accuracy or RT) N/A No interaction effect (cortisol, HR, HRV, or LF/HF bands) 2 groups (active vs. sham) 2. NIBS - 10–20 system 0.5 mA 30s ramp up/ramp down Control: None (1 session) 19mins Sham: Yes NIBS : None NIBS : N/A NIBS : LF/HF bands NOTE: Only responders analyzed De Smet et al (2021) ♀ & ♂ 18–45 yrs (N = 69) Within subjects crossover (active vs. sham tDCS) + active iTBS 1. NIBS 1 tDCS/dlPFC (bifrontal) tDCS Anode and cathode were respectively placed over F3 and F4 2 mA 30s ramp up/ramp down 20mins Sham: Yes Stress : N/A Stress : ↑ perceived stress & negative affect Stress : ↑ BP, HR, HRV, and EDA N/A No interaction effect (perceived stress and negative affect) No interaction effect (BP, HR, HRV, or EDA) Control: None 2.…”

Resting HRV as a trait marker of rumination in healthy individuals? A large cross-sectional analysis

“…A group of 1245 healthy participants (197M/1048F) with a mean age of 21.55 (SD = 3.05, ranging from 17-48 years old) were included in our dataset. All subjects participated in 14 experiments in our laboratory, the specific experimental information is listed in the supplementary material (Allaert et al, 2021(Allaert et al, , 2022De Smet et al, 2021;DeWandel et al, 2022;. Although there were differences in the inclusion criteria from study to study, all studies excluded participants with cardiovascular disease and psychiatric disorders.…”