Transcranial direct current stimulation versus intermittent theta-burst stimulation for the improvement of working memory performance

Razza, Laís B.; Luethi, Matthias S.; Zanão, Tamires; Smet, Stefanie De; Buchpiguel, Carlos Alberto; Busatto, Geraldo F.; Pereira, Juliana; Klein, Izio; Kappen, Mitchel; Moreno, María Alejandra; Baeken, Chris; Vanderhasselt, Marie‐Anne; Brunoni, André R.

doi:10.1016/j.ijchp.2022.100334

Cited by 9 publications

(12 citation statements)

References 43 publications

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“…This study was based on data from a previous trial that measured working memory performance of healthy subjects after a course of NIBS protocols. The original study used a factorial, double-blinded, within-subjects design, in which participants were allocated to receive four different NIBS interventions (tDCS, iTBS, combined tDCS+iTBS, and placebo) on different days, in a randomized order ( 22 ) (the study design can be visually checked in the Supplementary Figure S1). The focus of our study was to investigate only the results of the tDCS, iTBS, and placebo groups, as the combined protocol is a novel intervention used only twice over the DLPFC, and our main objective was to investigate the impact of within-individual variability in more standard NIBS techniques.…”

Section: Methodsmentioning

confidence: 99%

“…In our previous study ( 22 ), 24 healthy subjects with a mean age of 28.7 years (standard deviation (SD)=6.95) were included. They were right-handed volunteers, aged 18 to 45 years, both sexes, without neuropsychiatric disorders and/or clinical diseases.…”

Section: Methodsmentioning

confidence: 99%

“…TDCS was applied with a current of 2 mA through saline-soaked sponges of 25 cm 2 and lasted 20 min (Neuroconn DC-Stimulator, Germany). Placebo tDCS used the same montage but delivered only an active current of 30 s on the beginning of the tDCS session ( 22 ).…”

Section: Methodsmentioning

confidence: 99%

“…Therefore, based on our prior research ( 22 ), we proposed to investigate whether individual baseline cortical thicknesses of regions of interest (ROIs) in the brain are associated with working memory performance of healthy individuals submitted to tDCS, iTBS, and placebo in a within-subject design. Cortical thickness was chosen as the outcome as a previous study showed that it can account for a high variance in tDCS response ( 18 ).…”

Section: Introductionmentioning

confidence: 99%

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Cortical thickness is related to working memory performance after non-invasive brain stimulation

Razza,

Vanderhasselt,

Luethi

et al. 2023

Braz J Med Biol Res

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Non-invasive brain stimulation (NIBS) probing the dorsolateral prefrontal cortex (DLPFC) has been shown to have little effect on working memory. The variability of NIBS responses might be explained by inter-subject brain anatomical variability. We investigated whether baseline cortical brain thickness of regions of interest was associated with working memory performance after NIBS by performing a secondary analysis of previously published research. Structural magnetic resonance imaging data were analyzed from healthy subjects who received transcranial direct current stimulation (tDCS), intermittent theta-burst stimulation (iTBS), and placebo. Twenty-two participants were randomly assigned to receive all the interventions in a random order. The working memory task was conducted after the end of each NIBS session. Regions of interest were the bilateral DLPFC, medial prefrontal cortex, and posterior cingulate cortex. Overall, 66 NIBS sessions were performed. Findings revealed a negative significant association between cortical thickness of the bilateral dorsolateral prefrontal cortex and reaction time for both tDCS (left: P=0.045, right: P=0.037) and iTBS (left: P=0.007, right: P=0.007) compared to placebo. A significant positive association was found for iTBS and posterior cingulate cortex (P=0.03). No association was found for accuracy. Our findings provide the first evidence that individual cortical thickness of healthy subjects might be associated with working memory performance following different NIBS interventions. Therefore, cortical thickness could explain - to some extent - the heterogeneous effects of NIBS probing the DLPFC.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Cortical thickness is related to working memory performance after non-invasive brain stimulation

Razza,

Vanderhasselt,

Luethi

et al. 2023

Braz J Med Biol Res

View full text Add to dashboard Cite

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“…2018 ) but also can enhance cortical excitability of target areas during the stimulation of the brain region of interest ( Suppa et al. 2016 ; Razza et al. 2023 ).…”

Section: Introductionmentioning

confidence: 99%

EEG microstates analysis after TMS in patients with subacute stroke during the resting state

Zhang,

Yang,

Yao

et al. 2023

Cerebral Cortex

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To investigate whether intermittent theta burst stimulation over the cerebellum induces changes in resting-state electroencephalography microstates in patients with subacute stroke and its correlation with cognitive and emotional function. Twenty-four stroke patients and 17 healthy controls were included in this study. Patients and healthy controls were assessed at baseline, including resting-state electroencephalography and neuropsychological scales. Fifteen patients received lateral cerebellar intermittent theta burst stimulation as well as routine rehabilitation training (intermittent theta burst stimulation–RRT group), whereas 9 patients received only conventional rehabilitation training (routine rehabilitation training group). After 2 wk, baseline data were recorded again in both groups. Stroke patients exhibited reduced parameters in microstate D and increased parameters in microstate C compared with healthy controls. However, after the administration of intermittent theta burst stimulation over the lateral cerebellum, significant alterations were observed in the majority of metrics for both microstates D and C. Lateral cerebellar intermittent theta burst stimulation combined with conventional rehabilitation has a stronger tendency to improve emotional and cognitive function in patients with subacute stroke than conventional rehabilitation. The improvement of mood and cognitive function was significantly associated with microstates C and D. We identified electroencephalography microstate spatiotemporal dynamics associated with clinical improvement following a course of intermittent theta burst stimulation therapy.

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The Effects of Transcranial Direct Current Stimulation (tDCS) on the Cognitive Functions: A Systematic Review and Meta-analysis

Narmashiri,

Akbari

2023

Neuropsychol Rev

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Transcranial direct current stimulation versus intermittent theta-burst stimulation for the improvement of working memory performance

Cited by 9 publications

References 43 publications

Cortical thickness is related to working memory performance after non-invasive brain stimulation

Cortical thickness is related to working memory performance after non-invasive brain stimulation

EEG microstates analysis after TMS in patients with subacute stroke during the resting state

The Effects of Transcranial Direct Current Stimulation (tDCS) on the Cognitive Functions: A Systematic Review and Meta-analysis

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