The protective effect of Naringenin against ovalbumin-induced allergic rhinitis in rats

Şahin, Abdulkadir; Sakat, Muhammed Sedat; Kılıç, Korhan; Aktan, Bülent; Yıldırım, Serkan; Kandemir, Fatih Mehmet; Dörtbudak, Muhammed Bahaeddin; Küçükler, Sefa

doi:10.1007/s00405-021-06769-7

Cited by 14 publications

(11 citation statements)

References 23 publications

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“…For estimating the nasal symptoms, the frequency of sneezing behaviors and nasal rubbing were counted. After internasal administration of OVA from days 22 to 28, the frequency of sneezing behavior and nasal rubbing was counted after 15 min and also counted the experimental conditions (blinded observation) (Şahin et al., 2021; Xu et al., 2021; Zhang & Kang, 2020).…”

Section: Methodsmentioning

confidence: 99%

Ajwain oil attenuates allergic response of ovalbumin‐induced allergic rhinitis via alteration of inflammatory, oxidative stress, and Th1/Th2 responses

Raghav²,

2021

J Food Biochem

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Background: Allergic rhinitis (AR) is an immune inflammatory‐related disorder that affects the nasal mucosa. Free radicals play a crucial role in the expansion of allergic reaction and the researcher used the antioxidant therapy to treat the disease. Trachyspermum ammi L. (Ajwain oil) is popular traditional medicine. It has been proved their potential effect on various diseases. Ajwain oil showed anti‐tumor, antioxidant, antidiabetic, anti‐inflammatory, and anti‐bacterial properties. Yet, the anti‐allergic effect of Ajwain oil is still not explored. In this experimental study, an ovalbumin (OVX)‐induced AR model was used to scrutinize the anti‐allergic, antioxidant and anti‐inflammatory effects of Ajwain oil. Materials and Methods: OVX was used to establish the AR model (sensitization days 1, 8, and 15) and given the oral treatment of Ajwain oil and Montelukast for 13 days. The spleen, lungs, and body weight were estimated. Sneezing, nasal discharge and rubbing are also estimated. Immunoglobin‐E (IgE), histamine, malondialdehyde (MDA), superoxide dismutase (SOD), heme oxygenase‐1 (HO‐1), nuclear factor erythroid 2‐related factor 2 (Nrf2), and inflammatory cytokines were scrutinized. Results: Ajwain oil significantly (p < .001) suppressed sneezing, nasal discharge and nasal rubbing along with increasing the spleen, lung and body weight. Ajwain oil significantly (p < .001) decreased the level of IgE, histamine, MDA, Nrf2, HO‐1, and increased the level of SOD. Ajwain oil significantly (p < .001) suppressed the number of eosinophils, neutrophils, macrophages, and epithelial cells. Ajwain oil significantly prevented the activation of the NF‐κBp65 and STAT3 signaling pathways that led to enhancing the synthesis of anti‐inflammatory cytokines and reducing the inflammatory, allergen‐specific type 2T helper cells (Th2), Th17 cytokines. Conclusion: The obtained data suggests that Ajwain oil has a promising anti‐allergic against allergic rhinitis in mice via anti‐allergic, antioxidant, and anti‐inflammatory effects. Practical applications Allergic rhinitis is a serious life‐threatening disease. Inflammatory reaction plays an important role in the expansion of AR diseases. Ajwain oil considerably increased the spleen weight and reduced lung weight. Ajwain oil suppressed the nasal rubbing, sneezing, and nasal discharge. Ajwain oil considerably suppressed the immunoglobin and inflammatory cytokines. The result suggests that Ajwain oil having the potential effect against the allergic rhinitis.

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Section: Methodsmentioning

confidence: 99%

Ajwain oil attenuates allergic response of ovalbumin‐induced allergic rhinitis via alteration of inflammatory, oxidative stress, and Th1/Th2 responses

Raghav²,

2021

J Food Biochem

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“…Oral administration of naringenin, a flavanone mostly found in citrus peel, was shown to significantly reduce nasal scratching score in rats with OVA-induced AR with improved histology in the nasal epithelium and decreased serum IgE, IL-4, and IL-5 [103]. In addition, naringenin inhibited TSLP production in PMA/Ionophore-activated human mast cells (HMC-1 cells) through inhibition of NF-κB and TSLP-induced mRNA expressions of IL-13, TNF-α, IL-17 receptors, and TSLP receptors in these cells [102]. Therefore, naringenin and many other flavonoids may have a protective role against allergic conditions in allergen-sensitized individuals by regulating TSLP, the key initiator of Th2-driven allergic inflammation.…”

Section: Dietary Flavonoids and Other Phytochemicalsmentioning

confidence: 96%

The Role of Diet and Nutrition in Allergic Diseases

Zhang

2023

Nutrients

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Allergic diseases are a set of chronic inflammatory disorders of lung, skin, and nose epithelium characterized by aberrant IgE and Th2 cytokine-mediated immune responses to exposed allergens. The prevalence of allergic diseases, including asthma, allergic rhinitis, and atopic dermatitis, has increased dramatically worldwide in the past several decades. Evidence suggests that diet and nutrition play a key role in the development and severity of allergic diseases. Dietary components can differentially regulate allergic inflammation pathways through host and gut microbiota-derived metabolites, therefore influencing allergy outcomes in positive or negative ways. A broad range of nutrients and dietary components (vitamins A, D, and E, minerals Zn, Iron, and Se, dietary fiber, fatty acids, and phytochemicals) are found to be effective in the prevention or treatment of allergic diseases through the suppression of type 2 inflammation. This paper aims to review recent advances in the role of diet and nutrition in the etiology of allergies, nutritional regulation of allergic inflammation, and clinical findings about nutrient supplementation in treating allergic diseases. The current literature suggests the potential efficacy of plant-based diets in reducing allergic symptoms. Further clinical trials are warranted to examine the potential beneficial effects of plant-based diets and anti-allergic nutrients in the prevention and management of allergic diseases.

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“…[17] Citrus fruits contain the flavonoid naringenin, which has anti-inflammatory, antioxidant, and cardiovascular benefits. [18] By blocking pro-oxidant enzymes, it demonstrates its antioxidant benefits through ROS scavenging and metal ion chelation and abilities. [19] Naringenin demonstrated a protective effect against radiation-induced lung damage in a rat study investigating the radioprotective efficacy of the compound.…”

Section: Introductionmentioning

confidence: 99%

“…Citrus fruits contain the flavonoid naringenin, which has anti‐inflammatory, antioxidant, and cardiovascular benefits [18] . By blocking pro‐oxidant enzymes, it demonstrates its antioxidant benefits through ROS scavenging and metal ion chelation and abilities [19] .…”

Section: Introductionmentioning

confidence: 99%

Naringenin, Hesperidin and Quercetin Ameliorate Radiation‐Induced Damage In Rats: In Vivo And In Silico Evaluations

Uguz,

Avcı,

Palabıyık

et al. 2024

Chemistry & Biodiversity

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In this study, we sought to determine how well naringenin, hesperidin, and quercetin prevented damage brought on by radiotherapy. During the investigation, 48 adult female Sprague Dawley rats were used. Eight groups of eight rats each were formed by randomly assigning the rats to the groups. The normal control group was represented by Group 1. Group 2 rats were those that received a dose of 15 Gray (Gy) of radiotherapy. The rats assigned to Group 3 received only Naringenin, whereas those assigned to Group 4 received only quercetine, and those assigned to Group 5 received only hesperidin. Rats in group 6,7 and 8 were received naringenin, quarcetin and hesperidin at a dose of 50 mg/kg daily for one week prior to radiotheraphy exposition. After radiotheraphy and phenolic compounds rats were sacrificed and some metabolic enzyme (aldose reductase (AR), sorbitol dehydrogenase (SDH), paraoxonase‐1 (PON1), butyrylcholinesterase (BChE) and glutathione S‐transferase (GST)) activity was determined in eye and brain tissues. It was found that phenolic compounds have protective effect against radiation‐induced damage because of their anti‐diabetic antioxidant and anti‐inflammatory properties. Furthermore, hesperidin exhibited favorable binding affinity for BChE in silico compared to other enzymes.

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The protective effect of Naringenin against ovalbumin-induced allergic rhinitis in rats

Cited by 14 publications

References 23 publications

Ajwain oil attenuates allergic response of ovalbumin‐induced allergic rhinitis via alteration of inflammatory, oxidative stress, and Th1/Th2 responses

Ajwain oil attenuates allergic response of ovalbumin‐induced allergic rhinitis via alteration of inflammatory, oxidative stress, and Th1/Th2 responses

The Role of Diet and Nutrition in Allergic Diseases

Naringenin, Hesperidin and Quercetin Ameliorate Radiation‐Induced Damage In Rats: In Vivo And In Silico Evaluations

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