The impact of simultaneous inoculation of Pseudomonas aeruginosa, Staphylococcus aureus, and Candida albicans on rodent burn wounds

Brandenburg, Kenneth S.; Weaver, Alan J.; Karna, S. L. Rajasekhar; Leung, Kai P.

doi:10.1016/j.burns.2021.02.025

Cited by 6 publications

(2 citation statements)

References 69 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…When it comes to invasive infection in burns, P. aeruginosa is the most common pathogen. It is necessary to inhibit its growth in order to prevent life-threatening burn infections [83,84]. Several studies showed that this microorganism has a great capacity to develop resistance against numerous antibiotics [85][86][87][88][89][90] through various mechanisms [86,[91][92][93].…”

Section: Rj Against P Aeruginosamentioning

confidence: 99%

See 1 more Smart Citation

Royal Jelly as a Nutraceutical Natural Product with a Focus on Its Antibacterial Activity

2022

View full text Add to dashboard Cite

Royal jelly (RJ) is one of the most valued natural products and is known for its health-promoting properties. Due to its therapeutic effects, it has been used in medicine since antiquity. Nowadays, several studies indicate that RJ acts as a powerful antimicrobial agent. Indeed, researchers shed light on its antioxidant and anticancer activity. RJ’s biological properties are related to its bioactive compounds, such as proteins, peptides, phenolic, and fatty acids. The aim of this review is to highlight recent findings on RJ’s main bioactive compounds correlated with its health-promoting properties. The available literature suggests that these bioactive compounds can be used as an alternative approach in order to enhance human health. Moreover, throughout this paper, we underline the prominent antibacterial effect of RJ against several target bacterial strains. In addition, we briefly discuss other therapeutic activities, such as antioxidative and anticancer effects, of this outstanding natural product.

show abstract

Section: Rj Against P Aeruginosamentioning

confidence: 99%

Section: Rj Against P Aeruginosamentioning

confidence: 99%

Royal Jelly as a Nutraceutical Natural Product with a Focus on Its Antibacterial Activity

2022

View full text Add to dashboard Cite

show abstract

An Injectable Living Hydrogel with Embedded Probiotics as a Novel Strategy for Combating Multifaceted Pathogen Wound Infections

Tao,

Zhang,

Wei

et al. 2024

Adv Healthcare Materials

View full text Add to dashboard Cite

Wound infections pose a significant challenge in healthcare, and traditional antibiotic treatments often result in the development of resistant pathogens. Addressing this gap, we introduced ProGel, a living hydrogel created by entrapping probiotic Lactobacillus plantarum as a therapeutic component within a gelatin matrix. With a double‐syringe system, ProGel can be easily mixed and applied, conforming swiftly to any wound shape and forming hydrogel in situ. It also demonstrated robust mechanical and self‐healing properties owing to the Schiff‐base bonds. ProGel sustained more than 80% viability of the entrapped L. plantarum while restricting their escape from the hydrogel. After a week of storage, more than 70% viability of the entrapped L. plantarum was preserved. Importantly, ProGel exhibited broad‐spectrum antimicrobial efficacy against pathogens commonly associated with wound infections, i.e., Pseudomonas aeruginosa (7Log reduction), Staphylococcus aureus (3‐7Log reduction), and Candida albicans (40‐70% reduction). Moreover, its cytocompatibility was affirmed through co‐culture with human dermal fibroblasts. The effectiveness of ProGel was further highlighted in more clinically relevant tests on human skin wound models infected with P. aeruginosa and S. aureus, where it successfully prevented the biofilm formation of these pathogens. This study showcases an injectable living hydrogel system for the management of complex wound infections.This article is protected by copyright. All rights reserved

show abstract

RETRACTED ARTICLE: Burn Wounds: Proliferating Site for Biofilm Infection

Wang

Li²,

et al. 2022

Appl Biochem Biotechnol

View full text Add to dashboard Cite

The impact of simultaneous inoculation of Pseudomonas aeruginosa, Staphylococcus aureus, and Candida albicans on rodent burn wounds

Cited by 6 publications

References 69 publications

Royal Jelly as a Nutraceutical Natural Product with a Focus on Its Antibacterial Activity

Royal Jelly as a Nutraceutical Natural Product with a Focus on Its Antibacterial Activity

An Injectable Living Hydrogel with Embedded Probiotics as a Novel Strategy for Combating Multifaceted Pathogen Wound Infections

RETRACTED ARTICLE: Burn Wounds: Proliferating Site for Biofilm Infection

Contact Info

Product

Resources

About