Insulin resistance and high molecular weight adiponectin in obese and non-obese patients with Polycystic Ovarian Syndrome (PCOS)

Shirazi, Farnaz Kamali Haghighi; Khodamoradi, Zohre; Jeddi, Marjan

doi:10.1186/s12902-021-00710-z

Cited by 35 publications

(24 citation statements)

References 35 publications

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“…Shirazi in 2021 [19] has showed in his crosssectional study a high incidence of insulin resistance in PCOS patients independent of obesity, and determined BMI related lower level of high molecular weight adiponectin in obese PCOS individuals.…”

Section: Discussionmentioning

confidence: 99%

The Value of Serum Adiponectin in Patients with Polycystic Ovary Syndrome

Deghaidy

Ahmed

Rakha

2021

JAMMR

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Background: Polycystic ovary syndrome (PCOS) is a common condition in women at reproductive age associated with reproductive and metabolic dysfunction. It may be the most common cause of anovulation, early pregnancy loss, and later pregnancy complications. Adiponectin is the most abundant adipokine and is mainly secreted from visceral fat cells. It might be responsible for the metabolic and neuroendocrine derangements characteristic of obesity and obesity-related disease, such as PCOS. We aimed to evaluate the level of serum adiponectin in PCOS and the potential use of adiponectin as a biomarker for PCOS. Methods: This case control study was carried on 100 patients, aged between 20–35 years, who were equally divided into four groups based on the diagnosis of PCOS; 2 case groups and 2 control groups. Group 1 were non-obese PCOS subjects with body mass index (BMI) <25 kg/m2. Group 2 were obese PCOS subjects with BMI >25 kg/m2. Control groups were selected as; group 3 were non-obese control group with BMI <25 kg/m2. Group 4 were obese control group with BMI >25 kg/m2. Results: Adiponectin was significantly lower in group 1 than group 3 and 4 (P2 and P3 <0.001). While it was significantly lower in group 2 than group 1, 3 and 4 and was significantly lower in group 4 than group 3 (P1 = 0.021, P4 and P5 <0.001). Conclusion: Serum adiponectin level may be taken into consideration as a biomarker for confirmation of PCOS diagnosis. The relationship between adiponectin and BMI suggests that adiponectin could serve as a marker for disease risk and provide opportunity for earlier intervention.

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Section: Discussionmentioning

confidence: 99%

The Value of Serum Adiponectin in Patients with Polycystic Ovary Syndrome

Deghaidy

Ahmed

Rakha

2021

JAMMR

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“…1,8,22 This unusual condition alters fat distribution pattern, obesity, muscle mass, and hormonal function such as hyperandrogenism and induces multiple health complications including dysfibrinolysis, intravascular thrombosis, dyslipidemia, cardiovascular risks, and PCOS (Figure 2). 1,8,22,41,42 Insulin stimulates gonadotrophinreleasing hormone (GnRH) secretion from the hypothalamus involving mitogen-activated protein kinase (MAPK) pathway and GnRH induces secretion of luteinizing hormone (LH) from adenohypophysis that augments ovarian steroidogenesis, specifically androgens. 22,43 Insulin suppresses insulin-like-growthfactor binding protein-1 (IGFBP-1) via PI3K pathway in hepatocyte and ovary that induces insulin-like-growth-factor-1 (IGF-1) availability.…”

Section: Crosstalk Between Insulin Resistance (Ir) and Pcosmentioning

confidence: 99%

An insight of association of insulin resistance with polycystic ovary syndrome

Basu¹,

Chakraborty²,

Samaddar³

et al. 2022

IJCAP

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Polycystic ovary syndrome (PCOS), a multifaceted condition, often has salient features like insulin resistance (IR). Abnormal alternation in insulin synthesis and function usually alters PCOS expressivity by deviating molecular and biochemical activity underlying this pathophysiology.This review intends to unveil the molecular basis of the genetic polymorphism of IR and its correlation with PCOS. It also highlights the existing methods of IR estimation. Searching of different articles using keywords including PCOS, IR, and polymorphism in various databases was performed to illustrate the review article.POCS, and IR are complex and multifactorial conditions in terms of the contributing factors, their interactions, and expressivity. Further studies on diversified genotype responses to environmental and ethnic variances are required for precise understanding.Insulin resistance (IR) and polycystic ovary syndrome (PCOS) are intricately interacted conditions that abnormally alter functions from genetic to organ system level. Complex gene-environment interactions make it difficult to understand the etiology and manifestation, and so diagnosis and management approaches of the heterogeneous pathophysiology are not foolproof. Further studies on genetic susceptibility related to ethnic distribution are essential for the implementation of personalized treatment of IR and PCOS.

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“…PCOS raises the risk of type 2 diabetes mellitus. Diseased women display resistance to insulin, independent of fat [ 2 ]. PCOS was assumed to occur from functional ovarian hyperandrogenism (FOH) generated by insufficient production of androgen [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

Insulin Resistance in Polycystic Ovarian Syndrome

Purwar¹,

Nagpure²

2022

Cureus

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Polycystic ovarian syndrome (PCOS) is one of the readily recognised endocrine gland illnesses in women, with an incidence range from 2.2% to 26% in India. Patients experiencing PCOS experience issues involving irregular menstrual periods, hirsutism, acne, being overweight, and impotence. Long-term, low-grade inflammation has emerged as a crucial factor leading to PCOS. A rise in glucose levels may stimulate oxidative stress and a troubling reaction from mononuclear cells (MNC) of females with PCOS, which normally do not rely on fat. This is required because MNC-derived macrophages are the major source of cytokine synthesis in big adipose tissue and similarly encourage adipocyte cytokine production. In summary, data reveal the substantial risks of insulin resistance in obese people who are suffering from PCOS. The findings of this specific lesson indicated that individuals with the conventional PCOS phenotype had obesity and higher insulin levels and insulin resistance, neglecting the absence of BMI differences from other phenotypes. These data show that insulin resistance is the most significant pathophysiological trait in people with PCOS.

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Insulin resistance and high molecular weight adiponectin in obese and non-obese patients with Polycystic Ovarian Syndrome (PCOS)

Cited by 35 publications

References 35 publications

The Value of Serum Adiponectin in Patients with Polycystic Ovary Syndrome

The Value of Serum Adiponectin in Patients with Polycystic Ovary Syndrome

An insight of association of insulin resistance with polycystic ovary syndrome

Insulin Resistance in Polycystic Ovarian Syndrome

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