Infective Endocarditis Due to <i>Corynebacterium</i> Species: Clinical Features and Antibiotic Resistance

Bläckberg, Anna; Falk, Linn; Oldberg, Karl; Olaison, Lars; Rasmussen, Magnus

doi:10.1093/ofid/ofab055

Cited by 18 publications

(11 citation statements)

References 22 publications

(15 reference statements)

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“… 12 The incidence is rare, but the mortality rate is substantial. A previous study 13 has reported 4246 IE cases caused by various pathogens over a 10-year period, only 30 of which were caused by Corynebacterium . The incidence rate during that period was as low as 0.032 IE/10 5 annually.…”

Section: Discussionmentioning

confidence: 99%

Corynebacterium striatum Endocarditis After Renal Transplantation Confirmed by Metagenomic Next-Generation Sequencing: Case Report and Literature Review

Zheng¹,

Shang²,

Du³

et al. 2022

IDR

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Background Potent immune-suppressive therapy has been demonstrated to increase the risk of infective endocarditis (IE) in renal recipients. Reports of Corynebacterium striatum ( C. striatum ) endocarditis in renal recipients are scarce, thus limiting understanding of the disease. Case Presentation We describe a case of native valve endocarditis caused by C. striatum in a 35-year-old male patient. The young man with end-stage renal failure underwent kidney transplantation because of autosomal dominant polycystic kidney disease. Ceftazidime was administered after the surgery according to routine procedures, and the patient was discharged on the 14th day after the surgery without any evidence of infection. The patient experienced fever on the 56th day, and Corynebacterium was cultured from the patient’s blood, in agreement with the results of testing of the donor kidney preservation solution. On the 64th day, multiple thromboses were found in the right external iliac artery, particularly around the anastomotic orifice of the transplanted renal artery. Vegetation was found in the posterior mitral valve tip on the 65th day. The patient had symptoms of persistent angina pectoris and chest tightness and underwent mitral valve replacement and vegetative resection. The patient eventually died. C. striatum was detected in the mitral valve and vegetation tissue with metagenomic next-generation sequencing. Conclusion C. striatum may cause endocarditis and endanger patients’ lives and thus warrants greater attention. Genotypic assays such as metagenomic next-generation sequencing are demonstrated to be effective in confirming species identity. Adequate anti-infection therapy and early surgery are required after IE is discovered.

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Section: Discussionmentioning

confidence: 99%

Corynebacterium striatum Endocarditis After Renal Transplantation Confirmed by Metagenomic Next-Generation Sequencing: Case Report and Literature Review

Zheng¹,

Shang²,

Du³

et al. 2022

IDR

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“…Notably, 70% of cases involved prosthetic valve endocarditis. All Corynebacterium isolates were susceptible to vancomycin, while resistance to penicillin G was commonly observed [ 10 ]. Therefore, our patient presented a unique case of Corynebacterium NVE, which is notable due to the typically high mortality rate associated with this condition.…”

Section: Discussionmentioning

confidence: 99%

Unusual Presentation of Corynebacterium Endocarditis in a Patient Without Conventional Risk Factors: A Case Report

Mohammadi,

Youssef,

Mohammadi

2024

Cureus

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Infective endocarditis (IE) is a widespread condition marked by the infection of native or prosthetic heart valves, the endocardial surface, or an indwelling cardiac device. While native-valve IE is uncommon, patients with IE represent a diverse spectrum. Some respond well to treatment with few complications, while others face severe complications and an increased risk of mortality. Various factors contribute to this outcome, including delayed diagnosis, underlying health conditions like immunocompromised status or chronic diseases, and intravenous drug use. The most prevalent causes of IE are typically streptococci and staphylococci. IE attributed to Corynebacterium species is an exceptionally rare phenomenon, especially in individuals lacking conventional risk factors. This report presents a distinctive case involving Corynebacterium endocarditis in a 63-year-old female with a medical history encompassing intracranial aneurysm, hypothyroidism, and alcoholic cirrhosis. The patient's initial symptoms included shortness of breath, neck pain, and generalized weakness. Despite an initial focus on mild flu-like symptoms and a suspected urinary tract infection, subsequent evaluation unveiled pancytopenia and positive blood cultures for Corynebacterium striatum , culminating in the diagnosis of mitral valve endocarditis. This intricate clinical scenario, replete with numerous complications, underscores the significance of considering unusual pathogens in atypical presentations of IE. It prompts further exploration into the underlying mechanisms contributing to such infrequent occurrences.

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“…In previous studies Corynebacterium spp. have been associated with CIED-associated endocarditis [7,8,[11][12][13][14][15]. In a study examining 30 IE episodes due to Corynebacterium spp., the median age of the patients was 71 years and 77% of them were male.…”

Section: Discussionmentioning

confidence: 99%

“…In the literature, Corynebacterium spp. defined into subtypes by using the VITEK 2 Compact (Biomerioux, France) automated system and the 16S rDNA sequence analysis methods [7,8,[11][12][13][14][15]. Our patient was a 55-year old man and the subspecies analysis could not be performed because such examinations could not be performed in our center.…”

Section: Discussionmentioning

confidence: 99%

Corynebacterium endocarditis in a patient with a cardiac implantable electronic device

Alkan¹,

Küçük²,

ŞAHİN³

et al. 2022

Iberoam J Med

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Cardiac implantable electronic device (CIED) infections have been rising around the world. Many microorganisms can lead to this disease. Corynebacterium species are catalase-positive Gram-positive bacilli, also known as "diphtheroids" or "coryneform" bacteria, were once almost universally dismissed as contamination when recovered from patients, but they are now increasingly being linked to serious infections and have the ability to form biofilms and rarely cause CIED infections and this can be complicated as infective endocarditis. Corynebacterium spp. are frequently overlooked as contaminants in blood cultures, yet they can cause a serious infective endocarditis (IE). Antibiotic resistance is increasing among Corynebacterium spp., and this makes treatment more challenging. There are few reports of IE caused by Corynebacterium spp., and more research is needed. Here, we report a case of 55- year old man with Corynebacterium spp. cardiac device-related infective endocarditis.

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Infective Endocarditis Due to Corynebacterium Species: Clinical Features and Antibiotic Resistance

Cited by 18 publications

References 22 publications

Corynebacterium striatum Endocarditis After Renal Transplantation Confirmed by Metagenomic Next-Generation Sequencing: Case Report and Literature Review

Corynebacterium striatum Endocarditis After Renal Transplantation Confirmed by Metagenomic Next-Generation Sequencing: Case Report and Literature Review

Unusual Presentation of Corynebacterium Endocarditis in a Patient Without Conventional Risk Factors: A Case Report

Corynebacterium endocarditis in a patient with a cardiac implantable electronic device

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