The Value of Neutrophil:Lymphocyte Ratio and Platelet:Lymphocyte Ratio in Predicting Clinical Severity in Children with Carbon Monoxide Poisoning

Bağcı, Zafer; Arslan, Abdullah; Arslan, Derya

doi:10.1007/s12098-021-03704-w

Cited by 8 publications

(8 citation statements)

References 26 publications

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“…Relative increase in LYM count is the most important determinant of PLR level reduction. Bağcı et al 40 reported that the degree of PLR reduction can help determine clinical severity of COP; however, we did not find statistically significant differences between the COP and control groups.…”

Section: Discussioncontrasting

confidence: 97%

“…Marchewka et al 49 reported that MPV was significantly negatively correlated with disease severity in COP. Akça et al and Bağcı et al 19,40 found no statistically significant difference between the severe COP group and mild to moderate COP group in terms of platelet count and MPV. According to previous research, the platelet count was statistically significantly higher in the severe group than in the control group in our study.…”

Section: Discussionmentioning

confidence: 91%

“…Although the number of leukocytes remains constant, a decrease in NEUs and an increase in LYMs can result in a significant decrease in NLR levels. The degree of NLR reduction can aid in determining clinical severity 40,41 . Moon et al found that over the first 12 hours after admission, patients with poor long-term neurological outcome had higher NEU, MON, and NLR levels as well as lower LYM counts than patients with a good outcome 42 .…”

Section: Discussionmentioning

confidence: 99%

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Clinical and Laboratory Characteristics Predicting the Severity of Carbon Monoxide Poisoning in Children

Güven

2023

Pediatr Emer Care

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Objectives: Carbon monoxide poisoning (COP) is extremely common throughout the world. The purpose of this study was to assess the demographic, clinical, and laboratory characteristics predicting the severity COP in children. Methods:The study included 380 children diagnosed with COP between January 2017 and January 2021 and 380 healthy controls. Carbon monoxide poisoning was diagnosed based on the medical history and a carboxyhemoglobin (COHb) level of more than 5%. The patients were classified as mild (COHb 10%), moderate (COHb 10%-25%), or severely (COHb > 25%) poisoned. Results:The mean age of the severe group was 8.60 ± 6.30, for the moderate group was 9.50 ± 5.81, for the mild group was 8.79 ± 5.94, and for the control group was 8.95 ± 5.98. The most common place of exposure was at home and all cases were affected accidentally. The coal stove was the most common source of exposure, followed by natural gas. The most common symptoms were nausea/vomiting, vertigo, and headache. Neurologic symptoms such as syncope, confusion, dyspnea, and seizures were more common in the severe group. A total of 91.3% of the children had hyperbaric oxygen therapy, 3.8% were intubated, and 3.8% were transferred to intensive care in the severe group, whereas no death or sequela was observed. Mean platelet volume and red cell distribution width had the highest area under the curve in the receiver operating characteristic analysis (0.659; 0.379). A positive and low statistically significant relationship was found between COHb levels and troponin and lactate levels in the severe group (P < 0.05).Conclusions: Carbon monoxide poisoning progressed more severely in children presented with neurological symptoms and have elevated red cell distribution width and mean platelet volume. Even in severe COP cases, satisfactory results have been obtained with early and appropriate treatment.

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Section: Discussioncontrasting

confidence: 97%

Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

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Clinical and Laboratory Characteristics Predicting the Severity of Carbon Monoxide Poisoning in Children

Güven

2023

Pediatr Emer Care

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“…According to the analyzes made in the study, there was no difference between the two groups in terms of MPV or platelet values, while the lymphocyte value was found to be higher in cases of severe poisoning. [11] In another study, patients were divided into 2 groups as those with and without severe CO poisoning, and WBC, lymphocyte, troponin, and MPV values were found to be higher in severe poisoning cases. [12] It was found that patients with high CO levels at admission had significantly higher troponin values in studies that examined patients with delayed neuropsychiatric sequelae after carbon monoxide poisoning.…”

Section: Discussionmentioning

confidence: 97%

Karbon Monoksit Zehirlenme Şiddeti ile Kan Parametrelerinin İlişkisi

Atiş

SARIKAYA

YAMAÇ

2022

Journal of Contemporary Medicine

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Introduction: Carbon monoxide (CO) poisoning is one of the most common poisonings worldwide. Many studies have investigated the relationship between predictive parameters and CO poisoning severity. We aimed to investigate the relationship between blood parameter values with poor outcome in CO poisoning, and CO values measured in blood. Material and Method:This is a retrospective study. Patients who had CO levels ≥10% in their blood gas were included in the study. Patients were divided into 2 groups as those who required hyperbaric oxygen and those who do not. Demographic data such as age, gender of the patients, as well as CO levels in the blood gases of the patients, hemoglobin, leukocyte, neutrophil, platelet counts of the blood count, and MPV and PDW values were recorded. Also, creatinine, troponin, CRP, ALT values were recorded as well. Results:The study was conducted with 110 patients. The mean age of the patients was 46.80±18.18 years. When the parameters were examined, the median WBC count of patients with patients who required HBO therapy was 8. 73 [7.54-11.83], and the median WBC count of patients who did not require HBO therapy was 8.01 [6.96-9.72] (p=0.038). The median lymphocyte count of patients who required HBO therapy was determined as 2. 73 [1.85-3.36], and this value was found to be higher than patients who did not require HBO therapy (p=0.026).Conclusion: WBC and lymphocyte counts are higher in CO poisoning patients who required hyperbaric oxygen therapy. But these two values were not found to be independent risk factors in predicting hyperbaric oxygen therapy.

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“…In two studies, leukocyte values were found to be high in CO poisoning cases that required HBO treatment (25,26). In the study carried out by Bağcı et al (27), who divided patients presenting with CO poisoning into two groups as mild-moderate and severe, no difference was found between the two groups in terms of platelet counts. In the present study, there were patients with leukocytosis and thrombocytosis.…”

Section: E a R L Y A C C E S Smentioning

confidence: 96%

Çocuk Acile Karbonmonoksit Zehirlenmesi ile Başvuran Hastaların Değerlendirilmesi

Tekeli

Bolat

Ünay

2022

Düzce Tıp Fakültesi Dergisi

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Aim: Carbon monoxide poisoning is one of the significant causes of intoxication and presentation to pediatric emergency departments, especially in winter. The primary aim of this study was to evaluate the demographic characteristics, and clinical and laboratory findings of pediatric patients who presented to the pediatric emergency department with carbon monoxide poisoning, and the secondary aim was to examine the laboratory values of the patients with impaired consciousness. Material and Methods: The demographic and clinical characteristics and laboratory values of 162 patients presented to the pediatric emergency department due to carbon monoxide poisoning between 2017 and 2020 were retrospectively analyzed. The laboratory parameters of the patients with and without symptoms of impaired consciousness were compared. Results: The mean age of the patients was 8.94±5.33 years, and the gender distribution was homogenous. The highest frequency of presentation was during winter. Nausea, vomiting, and headache were the most common symptoms. Fifteen of the patients had impaired consciousness. While the laboratory values of the patients were generally within normal ranges, patients with high carboxyhemoglobin, lactate, and troponin values, and low pH were encountered. The carboxyhemoglobin and lactate levels of patients with impaired consciousness were found to be significantly higher than the patients without impaired consciousness (p<0.001 and p=0.019, respectively). Conclusion: Elevated carboxyhemoglobin and lactate levels were associated with impaired consciousness. Although carboxyhemoglobin levels are important for diagnosis and clinical follow-up, they should not be used as the only marker. High lactate and troponin levels, and low pH should also be taken into account.

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The Value of Neutrophil:Lymphocyte Ratio and Platelet:Lymphocyte Ratio in Predicting Clinical Severity in Children with Carbon Monoxide Poisoning

Cited by 8 publications

References 26 publications

Clinical and Laboratory Characteristics Predicting the Severity of Carbon Monoxide Poisoning in Children

Clinical and Laboratory Characteristics Predicting the Severity of Carbon Monoxide Poisoning in Children

Karbon Monoksit Zehirlenme Şiddeti ile Kan Parametrelerinin İlişkisi

Çocuk Acile Karbonmonoksit Zehirlenmesi ile Başvuran Hastaların Değerlendirilmesi

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