A novel zinc complex with antibacterial and antioxidant activity

Abstract

Background In order to enhance the antibacterial activity and reduce the toxicity of Zn2+, novel complexes of Zn(II) were synthesized. Results A water-soluble zinc-glucose-citrate complex (ZnGC) with antibacterial activity was synthesized at pH 6.5. The structure, morphology, characterization, acute toxicity, antibacterial and antioxidant activities, and in situ intestinal absorption were investigated. The results showed that zinc ion was linked with citrate by coordinate bond while the glucose was linked with it through intermolecular hydrogen bonding. The higher the molecular weight of sugar is, the more favorable it is to inhibit the formation of zinc citrate precipitation. Compared with ZnCl2, ZnGC complex presented better antibacterial activity against Staphylococcus aureus (S. aureus, Gram-positive) and Escherichia coli (E. coli, Gram-negative). Conclusions The results of acute toxicity showed no obvious toxicity in this test and in situ intestinal absorption study, suggesting that ZnGC complex could be used as a potential zinc supplement for zinc deficiency.

Photodynamic Alginate Zn-MOF Thermosensitive Hydrogel for Accelerated Healing of Infected Wounds

“…Compared with Ce6-Gel with Laser group, the Ce6@MOF-Gel with Laser had better wound healing effectivity, which may be related to the destruction of bacterial cell membranes by Zn-MOF and the improvement of PDT effects within bacteria. 23 In vivo antibacterial effects were further evaluated by the bacterial colony assay on day 13 (Figure 5d,e). Ce6@MOF-Gel with Laser group displayed higher bactericidal efficacy than that in PBS-Gel, Positive, Ce6-Gel with Laser, and MOF-Gel with Laser groups (P < 0.01), which was consistent with the results of in vitro antibacterial evaluation.…”

“…Zinc ions (Zn 2+ ), as a trace element required by normal physiological processes, can be easily metabolized and cleared without obvious side effects. They have an ideal antibacterial effect and are beneficial to cell proliferation and differentiation. − Therefore, the combination of Zn-MOF with PDT will efficiently suppress bacterial infection.…”

Zn-containing Wollastonite with Well-defined Microstructural and Good Antifungal Activity

“…Zn 2+ has superior antibacterial activity, owing to the antagonistic effect of Ca 2+ and Zn 2+ release. Zinc ions certainly disturbs the antibacterial activity and cellular reaction, thus providing an attractive bone ller alternate [8,9]. By means of raising the concentrations of zinc, antibacterial action extended in the inhibition zones as mentioned by El-Bassyouni et al, upon investigating the doping of the hydroxyapatite (HA) with diverse percentages of Zn [10] .…”

Highly specific fluorescent probes toward acetic acid via structural transformation of zinc complexes

“…Usually, transition organometallic probes possess the following characteristics: (1) highly luminous efficiency, long lifetime and high stability; (2) large Stokes shift of excitation and emission, and easy regulation of excitation and emission wavelengths; and (3) low cell imaging incubation concentration and less interference of normal cell activity. 26,27 Meanwhile, because of their low price and non-toxicity, easy functional modification and synthesis, photochemical stability, and desirable photophysical properties, 28–37 zinc complexes are widely used as excellent luminescent materials.…”