Rose bengal-mediated photodynamic inactivation against periodontopathogens in vitro

Dongqing, Wang; Pan, Hui; Yan, Yuwei; Zhang, Fengqiu

doi:10.1016/j.pdpdt.2021.102250

Cited by 10 publications

(6 citation statements)

References 39 publications

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“… 53 160 μg/mL 450–470 nm LED 109 12 A promising alternative for treating periodontal pathogens, particularly in eradicating A. actinomycetemcomitans . 54 Erythrosine 25 μM 500–600 nm halogen-based composite curing light 663.72 mW/cm 2 39.82 The therapy can effectively reduce the amount of dental plaque microbes and may be useful for preventing and treating dental plaque in both daily life. 55 22 μM LED: 440–480 nm/diode laser: 830 nm LED: 570 mW/cm 2 diode laser: 400 mW/cm 2 – The blue light source used for photopolymerizing dental composite material can also be used in conjunction with the plaque disclosing agent erythrosine to significantly reduce the main Gram-negative periodontal pathogens.…”

Section: Photosensitizermentioning

confidence: 99%

“…explored the combination of RB and medium-power blue light for the treatment of periodontal pathogens, especially Aggregatibacter actinomycetemcomitans ( A. actinomycetemcomitans ) and showed that this treatment reduced inflammation and promoted the healing of periodontal pockets. 54 In short, RB-mediated aPDT may be a promising therapeutic tool for periodontal diseases.…”

Section: Photosensitizermentioning

confidence: 99%

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Antimicrobial photodynamic therapy for the treatment of oral infections: A systematic review

Jao

Ding

Chen

2023

Journal of Dental Sciences

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Section: Photosensitizermentioning

confidence: 99%

Section: Photosensitizermentioning

confidence: 99%

Antimicrobial photodynamic therapy for the treatment of oral infections: A systematic review

Jao

Ding

Chen

2023

Journal of Dental Sciences

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“…Green light with a peak absorption of 500–551 nm has been studied for its efficacy in aPDT along with the chemical substrate rose bengal (4,5,6,7-tetrachloro 2′,4′,5′,7′-tetraiodo). Rose bengal is a fluorescein derivative that absorbs light within the green spectral region (550 nm peak absorption) [ 92 ] and has been tested as a photosensitizer to eliminate cancer cells and for its anti-infective properties against numerous infectious agents [ 93 , 94 , 95 ], including those responsible for ocular infections [ 96 , 97 , 98 ]. Like many photosensitizers, it shows an affinity to Gram-positive bacteria, likely due to the lack of outer membrane that is characteristic of Gram-negative bacteria.…”

Section: Ocular Infections: Overcoming Therapeutic Challenges With No...mentioning

confidence: 99%

Managing Corneal Infections: Out with the old, in with the new?

Marasini,

Craig,

Dean

et al. 2023

Antibiotics

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There have been multiple reports of eye infections caused by antibiotic-resistant bacteria, with increasing evidence of ineffective treatment outcomes from existing therapies. With respect to corneal infections, the most commonly used antibiotics (fluoroquinolones, aminoglycosides, and cephalosporines) are demonstrating reduced efficacy against bacterial keratitis isolates. While traditional methods are losing efficacy, several novel technologies are under investigation, including light-based anti-infective technology with or without chemical substrates, phage therapy, and probiotics. Many of these methods show non-selective antimicrobial activity with potential development as broad-spectrum antimicrobial agents. Multiple preclinical studies and a limited number of clinical case studies have confirmed the efficacy of some of these novel methods. However, given the rapid evolution of corneal infections, their treatment requires rapid institution to limit the impact on vision and prevent complications such as scarring and corneal perforation. Given their rapid effects on microbial viability, light-based technologies seem particularly promising in this regard.

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“…In recent years the photodynamic activity of bengal rose activated with blue or green light against selected bacterial strains and fungi has been reported (de Oliveira Silva et al, 2023;Hung et al, 2022;Kitanaka et al, 2020;Wang et al, 2021). However, according to our knowledge, the differences between the sensitivity of Gram-positive and Gram-negative bacterial strains in the presence of this photosensitiser activated with green light have not described.…”

Section: Introductionmentioning

confidence: 99%

The effect of rose bengal activated with green diode laser light on selected Gram-positive and Gram-negative bacterial strains

Greczek-Stachura,

Różanowski,

Kania

2023

AUPCStudiaNaturae

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In recent years the photodynamic activity of rose bengal activated with green light against selected bacterial strains has been reported. However, according to our knowledge, the differences between the sensitivity of Gram-positive and Gram-negative bacterial strains in the presence of this photosensitizer have not been described. The aim of the conducted research was to examine the antibacterial effect of 535 nm wavelength diode laser light in the presence of rose bengal as photosensitizer on selected reference bacterial strains: Pseudomonas aeruginosa, Enterococcus faecalis, Escherichia coli, Klebsiella pneumoniae and Staphylococcus aureus. Sterile 96-well microtiter plates were used to determine the antibacterial activity of the green light and rose bengal solutions at various concentrations. The labelled bacterial suspensions were placed to each well of the 96-well microtiter plate filled with liquid medium LB and solution of rose bengal. The plates were exposed to green diode laser light. After 24 hours of incubation at 37oC, the turbidance was read in a spectrophotometer. The irradiation in the presence of photosensitizer can act in an antibacterial manner, either bacteriostatically or bactericidally. The tested strains exhibit different sensitivity to irradiation because of the structure of the cell wall, the presence of different bacterial pigments and photoreceptor proteins in some species of bacteria. Gram-positive bacteria, Staphylococcus aureus and Enterococcus faecalis were the most photosensitive strains due to the higher possibility of rose bengal penetration into the bacterial cell, leading to the bacteriostatic effect. Our results show that rose bengal may be applied in the treatment of Gram-positive infections.

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Rose bengal-mediated photodynamic inactivation against periodontopathogens in vitro

Cited by 10 publications

References 39 publications

Antimicrobial photodynamic therapy for the treatment of oral infections: A systematic review

Antimicrobial photodynamic therapy for the treatment of oral infections: A systematic review

Managing Corneal Infections: Out with the old, in with the new?

The effect of rose bengal activated with green diode laser light on selected Gram-positive and Gram-negative bacterial strains

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