Obstructive sleep apnea is associated with impaired renal function in patients with diabetic kidney disease

Zamarrón, Ester; Oriol, Ana Jaureguízar; García‐Sánchez, Aldara; Díaz-Cambriles, Trinidad; Alonso-Fernández, Alberto; Lores, Vanesa; Mediano, Olga; Rodríguez-Rodríguez, Paula; Cabello-Pelegrín, Sheila; Morales, Enrique; Ramirez-Prieto, María Teresa; Valiente-Díaz, María Isabel; Gómez-García, Teresa; García‐Río, Francisco

doi:10.1038/s41598-021-85023-w

Cited by 20 publications

(9 citation statements)

References 51 publications

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“…A multicenter, observational, cross-sectional study using 214 DKD patients showed that UACR was higher in DKD with severe OSA relative to moderate OSA, mild OSA, or non-OSA subjects. Additionally, this study showed that the estimated GFR (eGFR) decreased in an OSA severity-dependent manner [90]. OSA-induced intermittent hypoxia and increased sympathetic nerve activity are associated with increased vascular complications, including endothelial damage and hypertension that leads to renal dysfunction [91].…”

Section: Sars-cov-2 Infection Exacerbates Diabetes-induced Renal Comp...mentioning

confidence: 84%

SARS-CoV-2 infection and Diabetes: Pathophysiological Mechanism of Multi-System Organ Failure

Roy¹,

Runa²

2022

Preprint

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Since the discovery of the Coronavirus disease 2019 (COVID-19) outbreak, a vast majority of studies have been carried out that confirmed the worst outcome of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in people with preexisting health conditions, including diabetes, obesity, hypertension, cancer, and cardiovascular diseases. Likewise, diabetes itself is one of the leading causes of global public health concerns that impose a heavy global burden on public health as well as socio-economic development. Both diabetes and SARS-CoV-2 infection have their independent ability to induce the pathogenesis and severity of multi-system organ dysfunction, while the co-existence of these two culprits can accelerate the pathophysiology and magnify the severity of the diseases. However, the exact pathophysiology of multi-system organ failure in diabetic patients after SARS-CoV-2 infection is still obscure. This review summarized the organ-specific possible molecular mechanisms of SARS-CoV-2 and diabetes-induced pathophysiology of several diseases of multiple organs, including the lungs, heart, kidney, brain, eyes, gastrointestinal system, and bones, and subsequent manifestation of multi-system organ failure.

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Section: Sars-cov-2 Infection Exacerbates Diabetes-induced Renal Comp...mentioning

confidence: 84%

SARS-CoV-2 infection and Diabetes: Pathophysiological Mechanism of Multi-System Organ Failure

Roy¹,

Runa²

2022

Preprint

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“…However, previous studies have indicated that nap duration and OSA may also be linked to eGFR in both healthy individuals and those with diabetes [18,[20][21][22] . It is also found that OSA and nap time may affect sleep duration [23,24] .…”

Section: Discussionmentioning

confidence: 99%

Association between sleep duration and estimated glomerular filtration rate in Chinese patients with diabetes: evidence from a cross-sectional study

Fu,

Deng,

Gan

et al. 2024

Preprint

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Previous epidemiological studies have demonstrated associations between sleep duration and diabetes, vascular complications and cardiovascular disease in diabetic patients. However, few studies have so far explored the effect of sleep time on estimated glomerular filtration rate (eGFR) in diabetic patients. This study was performed for the purpose of exploring the relationship between sleep duration and eGFR in diabetic patients. This study analyzed 1389 patients with diabetes. Sleep duration at night was categorized into four groups: very short (< 6h), short (6-6.9h), optimal (7-8h), and long (> 8h). The association of sleep duration with eGFR was analyzed using univariate linear regression, and generalized additive models were applied to assess the nonlinear relationship between sleep duration and eGFR. Compared to optimal sleep duration (7-8h), both long sleep duration (> 8h) and very short sleep duration (< 6h) were associated with level of eGFR (β = -3.63, 95%CI: -5.54 to -1.71, P = 0.0002 and β = -4.79, 95%CI: -8.55 to -1.03, P = 0.0126, respectively). The smooth curve showed there is a U-shaped relationship between sleep duration and eGFR levels. The results of this study show that both very short and long sleep durations were associated with low eGFR in diabetics.

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“…Sleep disorder can lead to inflammation, oxidative stress, endothelial dysfunction, increased sympathetic tone, activation of the renin-angiotensin system, circadian timing dysfunction and subsequent systemic and intraglomerular pressure, which hereby adversely affects kidney function ( 24 – 26 , 31 , 32 ). Another possible explanation is the impact of sleep disorder on hypertension ( 33 , 34 ), diabetes ( 35 , 36 ), obesity ( 37 ), and metabolic syndrome ( 38 ), which were known to accelerate deterioration of kidney function.…”

Section: Discussionmentioning

confidence: 99%

Association of sleep characteristics with renal function in menopausal women without recognized chronic kidney disease

Tong

Li²,

Hu³

et al. 2022

Front. Psychiatry

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ObjectiveTo delineate the association between sleep characteristics and renal function in peri-post menopause free of Chronic kidney disease (CKD) as well as cardiometabolic and hormone indicators.MethodsCross-sectional data from a total of 823 Han-Chinese women aged 40–67 years who visited the Menopause Clinic in the Shanghai Sixth People’s Hospital from November 2011 to November 2020 were analyzed through the Pittsburgh Sleep Quality Index (PSQI) and serum cystatin C (Cys-C). Logistic regression models were used to assess the association between cumulative/each sleep parameter and renal function after adjusting for cardiometabolic variables.ResultsAfter confounding factors, we identified that poor perceived sleep quality, shorter sleep duration (<6 h), low sleep efficiency (<75%), delayed sleep latency and worse sleep disturbance elevated more than doubled the odds ratio for declining renal function (≥0.91 mg/dL, the highest Cys-C) in postmenopause in a graded fashion. Meanwhile, multiple logistic regression analysis revealed that sleep disorder (PSQI ≥ 8), late postmenopause, highest quartile independently increased the odds ratio for declining renal function (OR 2.007, 95% CI: 1.408–2.861, OR = 3.287, 95%CI: 3.425–8.889, OR = 2.345, 95% CI: 1.310–4.199, respectively), while participants with menopausal hormone replacement (MHT) lower the odds of declining renal function (OR = 0.486, 95% CI: 0.324–0.728).ConclusionThe findings proposed that maintaining good sleep quality should be attached great importance to postmenopausal women, which provides clinical evidence for the feasible early detection and effective prevention such as MHT of renal disease progression in postmenopausal women.

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Obstructive sleep apnea is associated with impaired renal function in patients with diabetic kidney disease

Cited by 20 publications

References 51 publications

SARS-CoV-2 infection and Diabetes: Pathophysiological Mechanism of Multi-System Organ Failure

SARS-CoV-2 infection and Diabetes: Pathophysiological Mechanism of Multi-System Organ Failure

Association between sleep duration and estimated glomerular filtration rate in Chinese patients with diabetes: evidence from a cross-sectional study

Association of sleep characteristics with renal function in menopausal women without recognized chronic kidney disease

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