A microbial marriage reminiscent of mitochondrial evolution

Lewis, William H.; Ettema, Thijs J. G.

doi:10.1038/d41586-021-00500-6

Cited by 2 publications

(1 citation statement)

References 11 publications

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“…The evolutionary origin of mitochondria is from archaebacteria that ordinarily transport vesicles in order to communicate with other living microorganisms, escape from host immune systems, and eliminate self-damaged materials [ 30 , 31 ]. Thus, MDVs formation has been proposed as the ancient homeostatic process in living cells at mitochondrial level under physiologic and mild stress conditions [ 21 , 32 ].…”

Section: Overview Of Mdvsmentioning

confidence: 99%

Mitochondria-derived vesicles and their potential roles in kidney stone disease

Chaiyarit

Thongboonkerd

2023

J Transl Med

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Recent evidence has shown significant roles of mitochondria-derived vesicles (MDVs) in mitochondrial quality control (MQC) system. Under mild stress condition, MDVs are formed to carry the malfunctioned mitochondrial components, such as mitochondrial DNA (mtDNA), peptides, proteins and lipids, to be eliminated to restore normal mitochondrial structure and functions. Under severe oxidative stress condition, mitochondrial dynamics (fission/fusion) and mitophagy are predominantly activated to rescue mitochondrial structure and functions. Additionally, MDVs generation can be also triggered as the major MQC machinery to cope with unhealthy mitochondria when mitophagy is unsuccessful for eliminating the damaged mitochondria or mitochondrial fission/fusion fail to recover the mitochondrial structure and functions. This review summarizes the current knowledge on MDVs and discuss their roles in physiologic and pathophysiologic conditions. In addition, the potential clinical relevance of MDVs in therapeutics and diagnostics of kidney stone disease (KSD) are emphasized.

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