Mitochondria-derived vesicles and their potential roles in kidney stone disease

Chaiyarit, Sakdithep; Thongboonkerd, Visith

doi:10.1186/s12967-023-04133-3

Cited by 7 publications

(2 citation statements)

References 196 publications

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“…The functions of renal structures depend on fatty acid β-oxidation and mitochondrial oxidative phosphorylation, during which a large number of ROS are formed [38]. Thus, the balance between the production of mitochondrial ROS and their neutralization via the AOD system is crucial for the normal function of mitochondria in the kidneys [39]. Most studies have claimed that mitochondrial dysfunction and the development of OS are the main pathogenetic factors responsible for the initiation and progression of DN [3,40].…”

Section: Dn: the Significance Of Determining Osmentioning

confidence: 99%

Diabetic Nephropathy: Significance of Determining Oxidative Stress and Opportunities for Antioxidant Therapies

Darenskaya

Kolesnikov

Semenova

et al. 2023

IJMS

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Diabetes mellitus (DM) belongs to the category of socially significant diseases with epidemic rates of increases in prevalence. Diabetic nephropathy (DN) is a specific kind of kidney damage that occurs in 40% of patients with DM and is considered a serious complication of DM. Most modern methods for treatments aimed at slowing down the progression of DN have side effects and do not produce unambiguous positive results in the long term. This fact has encouraged researchers to search for additional or alternative treatment methods. Hyperglycemia has a negative effect on renal structures due to a number of factors, including the activation of the polyol and hexosamine glucose metabolism pathways, the activation of the renin–angiotensin–aldosterone and sympathetic nervous systems, the accumulation of advanced glycation end products and increases in the insulin resistance and endothelial dysfunction of tissues. The above mechanisms cause the development of oxidative stress (OS) reactions and mitochondrial dysfunction, which in turn contribute to the development and progression of DN. Modern antioxidant therapies for DN involve various phytochemicals (food antioxidants, resveratrol, curcumin, alpha-lipoic acid preparations, etc.), which are widely used not only for the treatment of diabetes but also other systemic diseases. It has also been suggested that therapeutic approaches that target the source of reactive oxygen species in DN may have certain advantages in terms of nephroprotection from OS. This review describes the significance of studies on OS biomarkers in the pathogenesis of DN and analyzes various approaches to reducing the intensity of OS in the prevention and treatment of DN.

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Section: Dn: the Significance Of Determining Osmentioning

confidence: 99%

Diabetic Nephropathy: Significance of Determining Oxidative Stress and Opportunities for Antioxidant Therapies

Darenskaya

Kolesnikov

Semenova

et al. 2023

IJMS

View full text Add to dashboard Cite

show abstract

“…Following publication of the original article [ 1 ], we have been notified that the Funding note was mentioned incorrectly. It should be as follows:…”

mentioning

confidence: 99%

Correction: Mitochondria-derived vesicles and their potential roles in kidney stone disease

Chaiyarit

Thongboonkerd

2023

J Transl Med

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The movement of mitochondria in breast cancer: internal motility and intercellular transfer of mitochondria

Libring,

Berestesky,

Reinhart-King

2024

Clin Exp Metastasis

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As a major energy source for cells, mitochondria are involved in cell growth and proliferation, as well as migration, cell fate decisions, and many other aspects of cellular function. Once thought to be irreparably defective, mitochondrial function in cancer cells has found renewed interest, from suggested potential clinical biomarkers to mitochondria-targeting therapies. Here, we will focus on the effect of mitochondria movement on breast cancer progression. Mitochondria move both within the cell, such as to localize to areas of high energetic need, and between cells, where cells within the stroma have been shown to donate their mitochondria to breast cancer cells via multiple methods including tunneling nanotubes. The donation of mitochondria has been seen to increase the aggressiveness and chemoresistance of breast cancer cells, which has increased recent efforts to uncover the mechanisms of mitochondrial transfer. As metabolism and energetics are gaining attention as clinical targets, a better understanding of mitochondrial function and implications in cancer are required for developing effective, targeted therapeutics for cancer patients.

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Mitochondria-derived vesicles and their potential roles in kidney stone disease

Cited by 7 publications

References 196 publications

Diabetic Nephropathy: Significance of Determining Oxidative Stress and Opportunities for Antioxidant Therapies

Diabetic Nephropathy: Significance of Determining Oxidative Stress and Opportunities for Antioxidant Therapies

Correction: Mitochondria-derived vesicles and their potential roles in kidney stone disease

The movement of mitochondria in breast cancer: internal motility and intercellular transfer of mitochondria

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