Sesquiterpene Lactones and Diterpenes: Promising Therapeutic Candidates for Infectious Diseases, Neoplasms and Other Chronic Disorders

Sülsen, Valeria P.

doi:10.3390/molecules26051251

Cited by 6 publications

(11 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In particular, the chemical composition of S. aristata was published by Zdero et al [46] in which beyerene derivatives and other terpenoids were reported. In vitro antiparasitic efficacy has been described for many compounds belonging to these groups [13,[47][48][49]. Interestingly, the effect of the sesquiterpene lactone eupatoriopicrin was determined on an in vivo model of T. cruzi infection [50].…”

Section: Discussionmentioning

confidence: 99%

Antiparasitic Effects of Asteraceae Species Extracts on Echinococcus granulosus s.s

Albani

Borgo

Fabbri

et al. 2022

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Cystic echinococcosis is a zoonotic disease caused by the parasite Echinococcus granulosus sensu lato (s.l.), which is worldwide distributed and causes long-lasting infections in animals and humans. The existing treatment is limited to the use of benzimidazoles, mainly albendazole (ABZ). However, it has unwanted side effects and its efficacy is about 50%. The Asteraceae family includes plants that have therapeutic applications (medicinal species) and has an important role in new drug development. The species belonging to a different genus of this family show a wide range of anti-inflammatory, antimicrobial, antioxidant, hepatoprotective, and antiparasitic activities, among others. The aim of the present study was to evaluate the in vitro efficacy of extracts of four Asteraceae species against protoscoleces of E. granulosus sensu stricto (s.s.). On the other hand, the Stevia aristata extract was assessed on the murine cyst of E. granulosus (s.s.) and the efficacy of S. aristata extract was investigated in a murine model of CE. Stevia satureiifolia, S. aristata, Grindelia pulchella, and G. chiloensis extracts at 100 μg/mL caused a decrease in protoscoleces viability; however, S. aristata extract produced the greatest in vitro protoscolicidal effect. After 20 days of treatment with the highest concentration (100 μg/mL) of S. aristata extract, protoscoleces viability decreased to 0%. The tegumental changes observed by scanning electron microscopy were consistent with the reduction in vitality. The collapse of the germinal layer was registered in 60 ± 5.8% and 83.3 ± 12.0% of cysts treated during 4 days with 50 and 100 μg/ml, respectively. The half maximal effective concentration (EC50) value of the S. aristata extract against E. granulosus (s.s.) cysts was 47.86 μg/mL (96 h). The dosage of infected animals with the 50 mg kg−1 dose of S. aristata extract resulted in a significant reduction in cyst weight in comparison with the control group. In conclusion, S. aristata extract was demonstrated to exert a marked effect, both in vitro and in the murine model.

show abstract

Section: Discussionmentioning

confidence: 99%

Antiparasitic Effects of Asteraceae Species Extracts on Echinococcus granulosus s.s

Albani

Borgo

Fabbri

et al. 2022

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…Stevia genus is characterized by the presence of sesquiterpene lactones, diterpenoids and flavonoids, among other phytochemical groups (Borgo et al ., 2021). Anti-parasitic activity has been described for many compounds belonging to these groups (Sanchez Alberti et al ., 2018; Boniface and Ferreira, 2019; Sessa et al ., 2020; Sülsen, 2021). Sesquiterpene lactones are one of the major phytochemical groups of compounds present in the genus Stevia .…”

Section: Discussionmentioning

confidence: 99%

Anthelmintic activity ofStevia multiaristataextract againstEchinococcus granulosus sensu stricto

et al. 2021

View full text Add to dashboard Cite

Cystic echinococcosis is a zoonotic disease caused by the larval stage of the parasite Echinococcus granulosus sensu lato. The available anti-parasitic treatment is mostly limited to a continuous administration of albendazole. However, due to its numerous side-effects and efficacy of around 50%, there is a need to find new drugs to improve the treatment for this disease. In the current study, the in vitro and in vivo efficacy of a Stevia multiaristata extract against E. granulosus sensu stricto (s.s.) was demonstrated. Stevia multiaristata extract (100 and 50 μg mL−1) caused a quick viability decrease on protoscoleces which was consistent with the observed tegumental alterations. Loss of turgidity was detected in 95 ± 3.4% of cysts incubated with S. multiaristata extract during 2 days (100 μg mL−1) and the collapse of the germinal layer was observed in 60 ± 9.3% of cysts treated with 100 μg mL−1 of the S. multiaristata extract during 4 days. The half maximal effective concentration value was 69.6 μg mL−1 and the selectivity index for E. granulosus s.s. cysts was 1.9. In this clinical efficacy study, the treatment of infected mice with the S. multiaristata extract (50 mg kg−1) caused a significant decrease in the weight of the cysts compared with the control group. These results coincided with the tissue damage observed in the cysts at the ultrastructural level. In conclusion, we observed high protoscolicidal and cysticidal effects, and significant reduction in the weight of the cysts in experimentally infected mice following treatment with the S. multiaristata extract.

show abstract

“…Tseng) (Wüpper et al., 2020), and red beet ( Beta vulgaris L.) (Mikolajczyk‐Bator & Kikut‐Ligaj, 2016), imparting them a remarkable bitter taste. Terpenoids are natural compounds derived from isoprene and could be classified into six groups based on their number of carbon atoms: monoterpenes (C10), sesquiterpenes (C15), diterpenes (C20), triterpenes (C30), tetraterpenes (C40), and polyterpenes (C > 40) (Sülsen, 2021). Monoterpenes are volatile aromatic compounds in plants that often constitute parts of the so‐called essential oils, such as limonene, a‐terpinene, and phellandrene (Böttger et al., 2018).…”

Section: Classification Of Bitter Compoundsmentioning

confidence: 99%

“…Due to their various biological effects on human health, plant terpenoids have received growing interest as promising sources of therapeutic agents for many diseases, such as cancer, infection disease, and other chronic disorders (Patlolla & Rao, 2012; Sülsen, 2021). Despite the impoartance of terpenoids in medicine and food science, their sensory properties have been poorly studied, and a better understanding of the molecular basis for their great bitterness is required.…”

Section: Classification Of Bitter Compoundsmentioning

confidence: 99%

An overview of bitter compounds in foodstuffs: Classifications, evaluation methods for sensory contribution, separation and identification techniques, and mechanism of bitter taste transduction

Yan

Hua-rong

2022

Comp Rev Food Sci Food Safe

View full text Add to dashboard Cite

The bitter taste is generally considered an undesirable sensory attribute. However, bitter-tasting compounds can significantly affect the overall flavor of many foods and beverages and endow them with various beneficial effects on human health. To better understand the relationship between chemical structure and bitterness, this paper has summarized the bitter compounds in foodstuffs and classified them based on the basic skeletons. Only those bitter compounds that are confirmed by human sensory evaluation have been included in this paper. To develop food products that satisfy consumer preferences, correctly ranking the key bitter compounds in foodstuffs according to their contributions to the overall bitterness intensity is the precondition. Generally, three methods were applied to screen out the key bitter compounds in foods and beverages and evaluate their sensory contributions, including dose-over-threshold factors, taste dilution analysis, and spectrum descriptive analysis method. This paper has discussed in detail the mechanisms and applications of these three methods. Typical procedures for separating and identifying the main bitter compounds in foodstuffs have also been summarized. Additionally, the activation of human bitter taste receptors (TAS2Rs) and the mechanisms of bitter taste transduction are outlined. Ultimately, a conclusion has been drawn to highlight the current problems and propose potential directions for further research.

show abstract

Sesquiterpene Lactones and Diterpenes: Promising Therapeutic Candidates for Infectious Diseases, Neoplasms and Other Chronic Disorders

Abstract: Nature is an important source for the discovery of new bioactive compounds. [...]

Cited by 6 publications

References 22 publications

Antiparasitic Effects of Asteraceae Species Extracts on Echinococcus granulosus s.s

Antiparasitic Effects of Asteraceae Species Extracts on Echinococcus granulosus s.s

Anthelmintic activity ofStevia multiaristataextract againstEchinococcus granulosus sensu stricto

An overview of bitter compounds in foodstuffs: Classifications, evaluation methods for sensory contribution, separation and identification techniques, and mechanism of bitter taste transduction

Contact Info

Product

Resources

About