NO, ROS, RAS, and PVAT: More Than a Soup of Letters

Barp, Clarissa Germano; Bonaventura, Daniella; Assreuy, Jamil

doi:10.3389/fphys.2021.640021

Cited by 17 publications

(8 citation statements)

References 78 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It can then repair the tissue damage caused by excessive NO, improve the synthesis of NA in nerve fibres, and restore the function of adrenergic nerves. The role of NO and ROS (and their potential interaction) in the pathological role of PVAT still require further investigation since antioxidant approaches as therapeutic options have failed to improve PVAT actions in cardiovascular diseases [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

Berberine ameliorates mesenteric vascular dysfunction by modulating perivascular adipose tissue in diet-induced obese in rats

Wang

Geng

et al. 2022

BMC Complement Med Ther

View full text Add to dashboard Cite

Background Berberine (BBR) has been found to have antiobesity effects, and obesity can lead to adipose tissue degeneration. As a special adipose tissue, perivascular adipose tissue (PVAT) is closely related to vascular function and affects vasoconstriction and relaxation. What happens to PVAT in the early stages of diet-induced obesity and how BBR affects vascular function is the focus of our experimental study. Methods Sprague–Dawley rats were fed a high-fat diet (fat 34% kcal) for 4 weeks to simulate early obesity. Obese rats were treated with BBR (200 mg/kg) or metformin (MET, 100 mg/kg) by gavage for 2 weeks. The mesenteric arterioles were studied by atomic force microscopy (AFM). The force vs. time curves were observed and analysed to indicate vascular function. Nitric oxide (NO) and noradrenaline (NA) release was quantified using an organ bath with fluorescence assays and ELISA, respectively. Network pharmacology was used to analyse the overlapping targets related to BBR and obesity-related diseases, and the expression of NOS in mesenteric PVAT was further analysed with immunohistochemistry and real-time PCR. The serum inflammatory factor levels were tested. Results BBR significantly reduced the levels of blood glucose, blood lipids and inflammatory factors in serum. It also effectively improved abnormal mesenteric vasoconstriction and relaxation in obese rats. There was no significant change in mesenteric vascular structure, but NO production and eNOS expression were significantly increased in mesenteric PVAT (P < 0.01), and NA was decreased (P < 0.05) in obese rats. All these changes in the mesenteric arterioles and PVAT of obese rats were reversed by treatment with BBR and MET. Conclusions In diet-induced obesity in rats, the function of vasoconstriction and relaxation in mesenteric arterioles is altered, NO is increased, and NA is decreased in mesenteric PVAT. All these changes were reversed by BBR, suggesting a novel effect of BBR in ameliorating mesenteric vascular dysfunction by regulating PVAT.

show abstract

Section: Discussionmentioning

confidence: 99%

Berberine ameliorates mesenteric vascular dysfunction by modulating perivascular adipose tissue in diet-induced obese in rats

Wang

Geng

et al. 2022

BMC Complement Med Ther

View full text Add to dashboard Cite

show abstract

“…By contrast, anti-inflammatory adipocytokines, particularly adiponectin, are reduced in dysfunctional PVAT [ 77 ]. Consequently, inflammation in obese PVAT exacerbates generation of ROS, particularly O 2 •– and H 2 O 2 [ 78 ]. Pharmacologically, co-incubation of obese PVAT-containing aortic segments with free radical scavengers and TNFα inhibitor could remarkably restore vascular function [ 79 ].…”

Section: Obesity and Pvatmentioning

confidence: 99%

Perivascular adipose tissue: Fine-tuner of vascular redox status and inflammation

et al. 2023

View full text Add to dashboard Cite

“…Moreover, PVAT was also shown to play a critical role in vascular regulation by local secretion of RAS components, including Ang II, as well as production of other entities which regulate vessels, blood pressure and inflammation, including leptin, IL-6, catecholamines and prostanoids, resistin and adiponectin ( 234 , 259 , 260 ). Angiotensin and aldosterone are both present in PVAT tissue and modulate endothelial dysfunction as well as immune cell infiltration ( 261 ).…”

Section: Role Of Perivascular Adipose Tissue In Aaa Developmentmentioning

confidence: 99%

Immune and inflammatory mechanisms of abdominal aortic aneurysm

Márquez-Sánchez

Koltsova

2022

Front. Immunol.

View full text Add to dashboard Cite

Abdominal aortic aneurysm (AAA) is a life-threatening cardiovascular disease. Immune-mediated infiltration and a destruction of the aortic wall during AAA development plays significant role in the pathogenesis of this disease. While various immune cells had been found in AAA, the mechanisms of their activation and function are still far from being understood. A better understanding of mechanisms regulating the development of aberrant immune cell activation in AAA is essential for the development of novel preventive and therapeutic approaches. In this review we summarize current knowledge about the role of immune cells in AAA and discuss how pathogenic immune cell activation is regulated in this disease.

show abstract

NO, ROS, RAS, and PVAT: More Than a Soup of Letters

Cited by 17 publications

References 78 publications

Berberine ameliorates mesenteric vascular dysfunction by modulating perivascular adipose tissue in diet-induced obese in rats

Berberine ameliorates mesenteric vascular dysfunction by modulating perivascular adipose tissue in diet-induced obese in rats

Perivascular adipose tissue: Fine-tuner of vascular redox status and inflammation

Immune and inflammatory mechanisms of abdominal aortic aneurysm

Contact Info

Product

Resources

About