2021
DOI: 10.3389/fphys.2021.640021
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NO, ROS, RAS, and PVAT: More Than a Soup of Letters

Abstract: Perivascular adipose tissue (PVAT) has recently entered in the realm of cardiovascular diseases as a putative target for intervention. Notwithstanding its relevance, there is still a long way before the role of PVAT in physiology and pathology is fully understood. The general idea that PVAT anti-contractile effect is beneficial and its pro-contractile effect is harmful is being questioned by several reports. The role of some PVAT important products or systems such as nitric oxide (NO), reactive oxygen species … Show more

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Cited by 17 publications
(8 citation statements)
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“…It can then repair the tissue damage caused by excessive NO, improve the synthesis of NA in nerve fibres, and restore the function of adrenergic nerves. The role of NO and ROS (and their potential interaction) in the pathological role of PVAT still require further investigation since antioxidant approaches as therapeutic options have failed to improve PVAT actions in cardiovascular diseases [ 40 ].…”
Section: Discussionmentioning
confidence: 99%
“…It can then repair the tissue damage caused by excessive NO, improve the synthesis of NA in nerve fibres, and restore the function of adrenergic nerves. The role of NO and ROS (and their potential interaction) in the pathological role of PVAT still require further investigation since antioxidant approaches as therapeutic options have failed to improve PVAT actions in cardiovascular diseases [ 40 ].…”
Section: Discussionmentioning
confidence: 99%
“…By contrast, anti-inflammatory adipocytokines, particularly adiponectin, are reduced in dysfunctional PVAT [ 77 ]. Consequently, inflammation in obese PVAT exacerbates generation of ROS, particularly O 2 •– and H 2 O 2 [ 78 ]. Pharmacologically, co-incubation of obese PVAT-containing aortic segments with free radical scavengers and TNFα inhibitor could remarkably restore vascular function [ 79 ].…”
Section: Obesity and Pvatmentioning
confidence: 99%
“…Moreover, PVAT was also shown to play a critical role in vascular regulation by local secretion of RAS components, including Ang II, as well as production of other entities which regulate vessels, blood pressure and inflammation, including leptin, IL-6, catecholamines and prostanoids, resistin and adiponectin ( 234 , 259 , 260 ). Angiotensin and aldosterone are both present in PVAT tissue and modulate endothelial dysfunction as well as immune cell infiltration ( 261 ).…”
Section: Role Of Perivascular Adipose Tissue In Aaa Developmentmentioning
confidence: 99%