Magnetic PLGA microspheres loaded with SPIONs promoted the reconstruction of bone defects through regulating the bone mesenchymal stem cells under an external magnetic field

Zhao, Ying‐Zheng; Chen, Rui; Xue, Pengpeng; Luo, Lan-Zi; Zhong, B.; Tong, Meng-Qi; Chen, Bin; Yao, Qing; Yuan, Jiandong; Xu, He‐Lin

doi:10.1016/j.msec.2021.111877

Cited by 28 publications

(21 citation statements)

References 64 publications

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“…Poly(lactic-glycolic acid) (PLGA) microspheres loaded with SPIONs by a water-in-oil-in-water (W/O/W) emulsionsolvent evaporation method were prepared to overcome the toxicity and small residence for the massively exposed SPIONs at bone defects. 107 The produced microspheres presented an average diameter that ranged between 160 and 200 μm, observed by SEM, and in terms of magnetic properties, the magnetic hysteresis curves indicated that SPIONs were superparamagnetic with Ms of 42.5 ± 2.1 emu g −1 . Later, the effects of magnetic PLGA microspheres on the cell attachment, proliferation, and osteogenic differentiation of BMSCs were evaluated under a permanent magnet (50 mT), showing that magnetoactive microspheres significantly promoted the proliferation, migration, osteogenic differentiation of BMSCs and upregulation of the expression of osteogenesisrelated proteins in vivo, which in turn led to the promotion of bone repair and reconstruction.…”

Section: Tailoring Mnps For Biomedical Applicationsmentioning

confidence: 92%

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Magnetic Nanoparticles for Biomedical Applications: From the Soul of the Earth to the Deep History of Ourselves

Martins

Lima

Ribeiro

et al. 2021

ACS Appl. Bio Mater.

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Precisely engineered magnetic nanoparticles (MNPs) have been widely explored for applications including theragnostic platforms, drug delivery systems, biomaterial/device coatings, tissue engineering scaffolds, performance-enhanced therapeutic alternatives, and even in SARS-CoV-2 detection strips. Such popularity is due to their unique, challenging, and tailorable physicochemical/magnetic properties. Given the wide biomedical-related potential applications of MNPs, significant achievements have been reached and published (exponentially) in the last five years, both in synthesis and application tailoring. Within this review, and in addition to essential works in this field, we have focused on the latest representative reports regarding the biomedical use of MNPs including characteristics related to their oriented synthesis, tailored geometry, and designed multibiofunctionality. Further, actual trends, needs, and limitations of magneticbased nanostructures for biomedical applications will also be discussed.

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Section: Tailoring Mnps For Biomedical Applicationsmentioning

confidence: 92%

“…Recently, it was successfully developed PLGA microspheres with SPIONS for TE applications. 107 The authors showed that PLGA with 1.38 wt. % of SPIONS microspheres promoted the osteoblasts in vitro differentiation of bone mesenchymal stem cells after 2 weeks of cell culture.…”

Section: Applications: From the Known To The Unknownmentioning

confidence: 99%

Magnetic Nanoparticles for Biomedical Applications: From the Soul of the Earth to the Deep History of Ourselves

Martins

Lima

Ribeiro

et al. 2021

ACS Appl. Bio Mater.

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“…bFGF-NP was synthesized using a modified double emulsion solvent evaporation technique, as in a previous study ( Zhao et al, 2021 ). Initially, 0.1 g PLGA and 0.01 g P407 were dissolved in 2 ml dichloromethane to form an oil phase.…”

Section: Methodsmentioning

confidence: 99%

Red Blood Cell Membrane-Camouflaged PLGA Nanoparticles Loaded With Basic Fibroblast Growth Factor for Attenuating Sepsis-Induced Cardiac Injury

Hong

Zhao

et al. 2022

Front. Pharmacol.

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Cardiac injury is recognized as a major contributor to septic shock and a major component of the multiple organ dysfunction associated with sepsis. Emerging evidence shows that regulation of the intramyocardial oxidative stress and inflammatory response has a promising prospect. Basic fibroblast growth factor (bFGF) exhibits anti-inflammatory and antioxidant properties. In this study, red blood cell membrane-camouflaged poly (lactide-co-glycolide) nanoparticles were synthesized to deliver bFGF (bFGF-RBC/NP) for sepsis-induced cardiac injury. The in vitro experiments revealed that bFGF-RBC/NP could protect cardiomyocytes from oxidative and inflammatory damage. In addition, the antioxidant and anti-inflammatory properties of bFGF-RBC/NP against cardiac injury were validated using data from in vivo experiments. Collectively, our study used bFGF for the treatment of sepsis-induced cardiac injury and confirmed that bFGF-RBC/NP has therapeutic benefits in the treatment of myocardial dysfunction. This study provides a novel strategy for preventing and treating cardiac injury in sepsis.

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“…2 ). Administration of these microspheres into rat femoral bone together with an external magnetic field remarkably improved the bone defect [ 98 ].…”

Section: Ionps In Combination With Non-carbohydrate Polymers For Msc Labellingmentioning

confidence: 99%

Iron Oxide Nanoparticles in Mesenchymal Stem Cell Detection and Therapy

Mehta

2022

Stem Cell Rev and Rep

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Mesenchymal stem cells (MSCs) exhibit regenerative and reparative properties. However, most MSC-related studies remain to be translated for regular clinical usage, partly due to challenges in pre-transplantation cell labelling and post-transplantation cell tracking. Amidst this, there are growing concerns over the toxicity of commonly used gadolinium-based contrast agents that mediate in-vivo cell detection via MRI. This urges to search for equally effective but less toxic alternatives that would facilitate and enhance MSC detection post-administration and provide therapeutic benefits in-vivo. MSCs labelled with iron oxide nanoparticles (IONPs) have shown promising results in-vitro and in-vivo. Thus, it would be useful to revisit these studies before inventing new labelling approaches. Aiming to inform regenerative medicine and augment clinical applications of IONP-labelled MSCs, this review collates and critically evaluates the utility of IONPs in enhancing MSC detection and therapeutics. It explains the rationale, principle, and advantages of labelling MSCs with IONPs, and describes IONP-induced intracellular alterations and consequent cellular manifestations. By exemplifying clinical pathologies, it examines contextual in-vitro, animal, and clinical studies that used IONP-labelled bone marrow-, umbilical cord-, adipose tissue- and dental pulp-derived MSCs. It compiles and discusses studies involving MSC-labelling of IONPs in combinations with carbohydrates (Venofer, ferumoxytol, dextran, glucosamine), non-carbohydrate polymers [poly(L-lysine), poly(lactide-co-glycolide), poly(L-lactide), polydopamine], elements (ruthenium, selenium, gold, zinc), compounds/stains (silica, polyethylene glycol, fluorophore, rhodamine B, DAPI, Prussian blue), DNA, Fibroblast growth Factor-2 and the drug doxorubicin. Furthermore, IONP-labelling of MSC exosomes is reviewed. Also, limitations of IONP-labelling are addressed and methods of tackling those challenges are suggested. Graphical Abstract

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Magnetic PLGA microspheres loaded with SPIONs promoted the reconstruction of bone defects through regulating the bone mesenchymal stem cells under an external magnetic field

Cited by 28 publications

References 64 publications

Magnetic Nanoparticles for Biomedical Applications: From the Soul of the Earth to the Deep History of Ourselves

Magnetic Nanoparticles for Biomedical Applications: From the Soul of the Earth to the Deep History of Ourselves

Red Blood Cell Membrane-Camouflaged PLGA Nanoparticles Loaded With Basic Fibroblast Growth Factor for Attenuating Sepsis-Induced Cardiac Injury

Iron Oxide Nanoparticles in Mesenchymal Stem Cell Detection and Therapy

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