Magnetic Nanoparticles for Biomedical Applications: From the Soul of the Earth to the Deep History of Ourselves

Martins, Pedro M.; Lima, Antônio Carlos Pedroso de; Ribeiro, Sylvie; Lanceros‐Méndez, S.

doi:10.1021/acsabm.1c00440

Cited by 92 publications

(56 citation statements)

References 221 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Magnetic nanoparticles (MNPs) have become ubiquitous in biomedical applications such as therapeutic microbots, [42] hyperthermia therapy for cancer, [43,44] and SARS-CoV-2 detection strips [45] owning to their great colloidal stability, biocompatibility and thermal property. [46] In our lab, we have developed a MNPs-incorporating linear PCL-based SMP for simultaneous thermo-chemotherapy. An elevation in temperature up to 57 °C was obtained by the application of alternating magnetic field on linear PCL-film containing a large amount of MNPs of 46.1 wt%.…”

Section: Laser Actuation Simulations Of Smp Stringmentioning

confidence: 99%

Smart Shape‐Memory Polymeric String for the Contraction of Blood Vessels in Fetal Surgery of Sacrococcygeal Teratoma

Fulati

Uto

Iwanaga

et al. 2022

Adv Healthcare Materials

View full text Add to dashboard Cite

Shape-memory polymers (SMPs) are promising materials in numerous emerging biomedical applications owing to their unique shape-memory characteristics. However, simultaneous realization of high strength, toughness, stretchability while maintaining high shape fixity (R f ) and shape recovery ratio (R r ) remains a challenge that hinders their practical applications. Herein, a novel shape-memory polymeric string (SMP string) that is ultra-stretchable (up to 1570%), strong (up to 345 MPa), tough (up to 237.9 MJ m −3 ), and highly recoverable (R f averagely above 99.5%, R r averagely above 99.1%) through a facile approach fabricated solely by tetra-branched poly(𝝐-caprolactone) (PCL) is reported. Notably, the shape-memory contraction force (up to 7.97 N) of this SMP string is customizable with the manipulation of their energy storage capacity by adjusting the string thickness and stretchability. In addition, this SMP string displays a controllable shape-memory response time and demonstrates excellent shape-memory-induced contraction effect against both rigid silicone tubes and porcine carotids. This novel SMP string is envisioned to be applied in the contraction of blood vessels and resolves the difficulties in the restriction of blood flow in minimally invasive surgeries such as fetoscopic surgery of sacrococcygeal teratoma (SCT).

show abstract

Section: Laser Actuation Simulations Of Smp Stringmentioning

confidence: 99%

Smart Shape‐Memory Polymeric String for the Contraction of Blood Vessels in Fetal Surgery of Sacrococcygeal Teratoma

Fulati

Uto

Iwanaga

et al. 2022

Adv Healthcare Materials

View full text Add to dashboard Cite

show abstract

“…The most commonly used iron oxide magnetic nanoparticles (MNPs) for biomedical applications are magnetite-based (Fe 3 O 4 ) due to their good biocompatibility, chemical stability, low toxicity profile, and superior biodegradability [1][2][3][4]. Under the influence of a high-frequency alternating magnetic field (AMF), MNPs generate heat due to their dynamic hysteresis response, which depends on their static hysteresis characteristics and on their ability to follow the changes in the AMF through relaxation mechanisms (as N éel and Brown) [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Zn-Substitution on the Morphological, Magnetic, Cytotoxic, and In Vitro Hyperthermia Properties of Polyhedral Ferrite Magnetic Nanoparticles

et al. 2021

View full text Add to dashboard Cite

The clinical translation of magnetic hyperthermia (MH) needs magnetic nanoparticles (MNPs) with enhanced heating properties and good biocompatibility. Many studies were devoted lately to the increase in the heating power of iron oxide MNPs by doping the magnetite structure with divalent cations. A series of MNPs with variable Zn/Fe molar ratios (between 1/10 and 1/1) were synthesized by using a high-temperature polyol method, and their physical properties were studied with different techniques (Transmission Electron Microscopy, X-ray diffraction, Fourier Transform Infrared Spectroscopy). At low Zn doping (Zn/Fe ratio 1/10), a significant increase in the saturation magnetization (90 e.m.u./g as compared to 83 e.m.u./g for their undoped counterparts) was obtained. The MNPs’ hyperthermia properties were assessed in alternating magnetic fields up to 65 kA/m at a frequency of 355 kHz, revealing specific absorption rates of up to 820 W/g. The Zn ferrite MNPs showed good biocompatibility against two cell lines (A549 cancer cell line and BJ normal cell line) with a drop of only 40% in the viability at the highest dose used (500 μg/cm2). Cellular uptake experiments revealed that the MNPs enter the cells in a dose-dependent manner with an almost 50% higher capacity of cancer cells to accommodate the MNPs. In vitro hyperthermia data performed on both cell lines indicate that the cancer cells are more sensitive to MH treatment with a 90% drop in viability after 30 min of MH treatment at 30 kA/m for a dose of 250 μg/cm2. Overall, our data indicate that Zn doping of iron oxide MNPs could be a reliable method to increase their hyperthermia efficiency in cancer cells.

show abstract

“…On the other hand, magnetic nanoparticles with surface modification, the introduction of a variety of functional groups, are versatile candidates for highly promising supports with unique features such as outstanding magnetic response and high dispersion in solvents, [26–29] which can be conveniently manipulated by an external magnetic field. At present, they have been successfully created as fascinating platforms united with biomedicine, synthetic chemistry and material science [30–32] . In continuation of our ongoing research for the development of catalytic oxidation system, [25,33–35] we were very interested to investigate the synthesis and the performance of our heterogeneous AZADO‐based catalysts through employing magnetic polystyrene nanospheres (MPNs), consisting of fine Fe 3 O 4 nanoparticles encapsulated by chloromethylated polystyrene shell, for the support.…”

Section: Introductionmentioning

confidence: 99%

“…At present, they have been successfully created as fascinating platforms united with biomedicine, synthetic chemistry and material science. [30][31][32] In continuation of our ongoing research for the development of catalytic oxidation system, [25,[33][34][35] we were very interested to investigate the synthesis and the performance of our heterogeneous AZADO-based catalysts through employing magnetic polystyrene nanospheres (MPNs), consisting of fine Fe 3 O 4 nanoparticles encapsulated by chloromethylated polystyrene shell, for the support. Up to now, there have been no reports on the MPNs decorated with the stable azaadamantane-type-nitroxyl radicals for the alcohol oxidation.…”

Section: Introductionmentioning

confidence: 99%

Heterogeneous Catalysis for Oxidation of Alcohol via 1‐Methyl‐2‐azaadamanane N‐oxyl Immobilized on Magnetic Polystyrene Nanosphere

Guo

Wang

et al. 2022

ChemistrySelect

View full text Add to dashboard Cite

Heterogeneous selective oxidation of alcohol to carbonyl compounds with stable organic nitroxyl radicals is highly attractive yet grand challenging. Described herein is a highly promising heterogeneous strategy for this reaction in which a catalytic amount of 1-methyl-2-azaadamanane N-oxyl immobilized on magnetic polystyrene nanosphere (1-Me-AZADO/ MPNs) was used and a series of carbonyl compounds were obtained from various alcohols in 73-99 % isolated yields and high selectivity (> 99 %) under Anelli conditions, thus offering a greener and more convenient methods in the synthesis of carbonyl compounds. The attractive features of convenient magnetic separation (within seconds), good recyclability (up to 20 runs) and fast reaction rates (5-20 min) were very efficient to improve the utility of azaadamantane-type-nitroxyl radicals in the oxygenation.

show abstract

Magnetic Nanoparticles for Biomedical Applications: From the Soul of the Earth to the Deep History of Ourselves

Cited by 92 publications

References 221 publications

Smart Shape‐Memory Polymeric String for the Contraction of Blood Vessels in Fetal Surgery of Sacrococcygeal Teratoma

Smart Shape‐Memory Polymeric String for the Contraction of Blood Vessels in Fetal Surgery of Sacrococcygeal Teratoma

The Effect of Zn-Substitution on the Morphological, Magnetic, Cytotoxic, and In Vitro Hyperthermia Properties of Polyhedral Ferrite Magnetic Nanoparticles

Heterogeneous Catalysis for Oxidation of Alcohol via 1‐Methyl‐2‐azaadamanane N‐oxyl Immobilized on Magnetic Polystyrene Nanosphere

Contact Info

Product

Resources

About