“…Associations between trisomy 12 and NOTCH1 mutations, as well as the deletion of 11q with SF3B1 or BIRC3 mutations, have been described, showing that these genetic mutations could further refine the prognosis of those cytogenetic subgroups [ 135 , 139 , 140 , 141 , 142 , 143 , 144 , 145 ]. Moreover, a recent study has shown that a subset of patients with a co-occurrence of 11q deletion and TP53 alterations had a highly adverse outcome [ 117 ]. By contrast, the mutations in MYD88 appeared in higher frequencies within 13q-deleted patients, being associated with a good prognosis and IGHV mutation [ 12 , 144 , 146 ].…”