Circadian Rhythms and the Transcriptional Feedback Loop (Nobel Lecture)**

Rosbash, Michael

doi:10.1002/anie.202015199

Cited by 33 publications

(14 citation statements)

References 112 publications

(49 reference statements)

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“…Rusak and Zucker [ 49 ] published a seminal paper in the Journal of Physiology in 1979 that declared rhythms in temporal organization to be comparable to homeostasis in promoting organismal fitness. Michael Rosbash’s 2017 Nobel Lecture [ 50 ] emphasized that optimal circadian organization, including temporal coupling or separation of various physiological, metabolic, and behavioral processes, is closely tied to fitness. Given the longstanding emphasis on integration within the field of physiology and acknowledgment that many crucial physiological processes vary across the day, one might reasonably expect publications in the field to emphasize time-of-day information in the methods section.…”

Section: Resultsmentioning

confidence: 99%

Time of day as a critical variable in biology

et al. 2022

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Background Circadian rhythms are important for all aspects of biology; virtually every aspect of biological function varies according to time of day. Although this is well known, variation across the day is also often ignored in the design and reporting of research. For this review, we analyzed the top 50 cited papers across 10 major domains of the biological sciences in the calendar year 2015. We repeated this analysis for the year 2019, hypothesizing that the awarding of a Nobel Prize in 2017 for achievements in the field of circadian biology would highlight the importance of circadian rhythms for scientists across many disciplines, and improve time-of-day reporting. Results Our analyses of these 1000 empirical papers, however, revealed that most failed to include sufficient temporal details when describing experimental methods and that few systematic differences in time-of-day reporting existed between 2015 and 2019. Overall, only 6.1% of reports included time-of-day information about experimental measures and manipulations sufficient to permit replication. Conclusions Circadian rhythms are a defining feature of biological systems, and knowing when in the circadian day these systems are evaluated is fundamentally important information. Failing to account for time of day hampers reproducibility across laboratories, complicates interpretation of results, and reduces the value of data based predominantly on nocturnal animals when extrapolating to diurnal humans.

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Section: Resultsmentioning

confidence: 99%

Time of day as a critical variable in biology

et al. 2022

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“…The Drosophila circadian clock system contains fewer circadian pacemaker neurons than humans, which enabled functional studies and, likely, the most precise definition of the molecular, genetic, physiological, and behavioral aspects of any circadian clock system [281]. In the fly, the setup of the circadian rhythm is regulated largely at the transcriptional level by the daily expression cycle of several genes, including period (per) [282][283][284] and timeless (tim) [285], as well as the pigment dispersing factor (pdf ) found in circadian pacemaker neurons [286] (reviewed in [287,288]). While the complex mammalian circadian rhythm relies on multiple clocks (reviewed in [289]), the basic organization of the oscillators is conserved between flies and mammals and several key proteins are also conserved.…”

Section: Melatonin Treatments In Drosophila Models Of Neurological Diseasementioning

confidence: 99%

Empowering Melatonin Therapeutics with Drosophila Models

et al. 2021

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Melatonin functions as a central regulator of cell and organismal function as well as a neurohormone involved in several processes, e.g., the regulation of the circadian rhythm, sleep, aging, oxidative response, and more. As such, it holds immense pharmacological potential. Receptor-mediated melatonin function mainly occurs through MT1 and MT2, conserved amongst mammals. Other melatonin-binding proteins exist. Non-receptor-mediated activities involve regulating the mitochondrial function and antioxidant cascade, which are frequently affected by normal aging as well as disease. Several pathologies display diseased or dysfunctional mitochondria, suggesting melatonin may be used therapeutically. Drosophila models have extensively been employed to study disease pathogenesis and discover new drugs. Here, we review the multiple functions of melatonin through the lens of functional conservation and model organism research to empower potential melatonin therapeutics to treat neurodegenerative and renal diseases.

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“…Understanding the complexity and heterogenicity in the pathogenesis of CRDs is essential to nullifying the unmet needs in the treatment of CRDs. The overall survival of organisms and their wellbeing depend on their synchronicity with their internal periodic cycles and the daily rotational cycles of the earth [9]. This synchronicity in mammals is controlled by a time-keeping system, or a biological clock, the suprachiasmatic nuclei (SCN) of the anterior hypothalamus brain region, the master circadian pacemaker of an organism that anticipates and reacts accordingly to the changes occurring in both the external and internal environments [10].…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Chronotherapy Targeting Respiratory Diseases

et al. 2021

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Respiratory diseases contribute to a significant percentage of mortality and morbidity worldwide. The circadian rhythm is a natural biological process where our bodily functions align with the 24 h oscillation (sleep–wake cycle) process and are controlled by the circadian clock protein/gene. Disruption of the circadian rhythm could alter normal lung function. Chronotherapy is a type of therapy provided at specific time intervals based on an individual’s circadian rhythm. This would allow the drug to show optimum action, and thereby modulate its pharmacokinetics to lessen unwanted or unintended effects. In this review, we deliberated on the recent advances employed in chrono-targeted therapeutics for chronic respiratory diseases.

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Circadian Rhythms and the Transcriptional Feedback Loop (Nobel Lecture)**

Cited by 33 publications

References 112 publications

Time of day as a critical variable in biology

Time of day as a critical variable in biology

Empowering Melatonin Therapeutics with Drosophila Models

Recent Advances in Chronotherapy Targeting Respiratory Diseases

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