Regulating metal–organic frameworks as stationary phases and absorbents for analytical separations

Meng, Shasha; Xu, Ming; Han, Ting; Gu, Yuhao; Gu, Zhi‐Yuan

doi:10.1039/d0ay02310h

Cited by 18 publications

(9 citation statements)

References 98 publications

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“…MOFs are a class of microporous crystalline hybrid materials, which have been widely used for the chromatographic separation of various molecules. [130][131][132] However, it is still a challenge for MOFs to separate biomolecules with larger size, for example, proteins. Recently, Choi, Kim, et al used a discriminate etching method (silver catalyzed decarboxylation, Figure 8a) to introduce larger pores within MOFs.…”

Section: Mofsmentioning

confidence: 99%

Emerging Nanoporous Materials for Biomolecule Separation

Song

Bao

Shen

et al. 2022

Adv Funct Materials

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Biomolecule separation plays a vital role in downstream applications ranging from omics research, structure analysis, and drug purification to clinical diagnosis. Among all existing materials and technologies towards biomolecule separation, nanoporous materials take the leading place. To achieve efficient biomolecule separation, the interface of nanoporous materials is always modified with a monolayer containing specific functional groups. However, the monolayer modification strategy still encounters bottlenecks due to extremely low abundance of target biomolecules, strong interference from high‐abundance background biomolecules, similar characteristics of compounds, unspecific adsorption, et al. Recently, several emerging nanoporous materials, which are prepared without the monolayer modification process, have been reported for high‐efficient, high‐specific, and rapid biomolecule separation. In this review, the authors summarize the emerging nanoporous materials for biomolecule separation, mainly focusing on the design principle and separation performance that are different from classical nanoporous materials. First, the classic design strategy of monolayer modification is discussed and the recent progress with this aspect is introduced. Then, emerging nanoporous materials beyond monolayer modification are introduced. At last, future developments, challenges, and great promise of biomolecule separation nanoporous materials are discussed.

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Section: Mofsmentioning

confidence: 99%

Emerging Nanoporous Materials for Biomolecule Separation

Song

Bao

Shen

et al. 2022

Adv Funct Materials

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“…Alkane isomers [139,140] 1000-1600 MOF-508 Xylene isomers [141] MIL-47 Ethylbenzene [142] Note: Adapted from McNair et al [10] and Grob et al [12] form free radicals, which cross-link to form a more stable, higher molecular weight gum phase. The cross-linking increases the thermal stability of the column as well as its insolubility in solvents, thus favouring cold rinsing and extending the lifetime of the stationary phase.…”

Section: Mof Mil-101mentioning

confidence: 99%

Experimental methods in chemical engineering: Gas chromatography—GC

et al. 2022

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Gas chromatography (GC) separates volatile and semi‐volatile liquids and gases based on their affinity for a stationary phase, either a thin liquid or a polymer layer on a solid. A gaseous mobile phase carries the volatile compounds from an injection port to a column with the stationary phase and then to an amdetector. The most common detectors are based on mass spectrometry (MS), thermal conductivity, and flame ionization. A furnace houses the columns and maintains or ramps temperatures to increase the separation efficiency—reduce run time or increase peak separation (resolution). The analyst chooses the chemistry of the stationary phase and the physical structure of the columns based on the polarity and functional groups of the solute. Packed columns tolerate impurities better than capillary columns that have a greater separating power and bleed the functional groups less. Efficiency is best when the sample polarity matches the column polarity. High temperatures and contamination cause columns to bleed the active components, which reduces the resolution but might also introduce ghost peaks to the chromatogram. The Web of Science assigned 15 000 articles to chemical engineering that mention GC and gas chromatography as keywords. Since 2017, it has indexed close to 1000 new articles every year. A bibliometric analysis classifies these contributions into four clusters: (1) pyrolysis and biomass, (2) GC–MS and extraction, (3) lignin and aromatics, and (4) decomposition and kinetics.

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“…这种选择性主要来源于 MOFs 结构中特有的孔的尺寸、形状对不同大小的气体分子的"分子筛"效应, 以及 MOFs 中的金属离子或有机配体与极性不同的分析物之间相互作用力的差异. 与常用的聚硅氧烷、聚乙二醇、沸石、碳材料等商用化固定相材料相比, MOFs 的优势在于结构中的孔径大小和孔内的化学环境具有多样性和可调控性, 这就为气体混合物的分离提供了更多的选择 [88][89] . 此外, 大部分 MOFs 具有良好的化学稳定性和热稳定性, 使用它们代替有机聚合物类的固定相, 可以解决后者存在的活性位点在含水、氧气的环境中不稳定, 容易造成固定相降解流失的问题.…”

Section: Mofs 在微型气体预富集器中的应用unclassified

Application of Metal-Organic Frameworks in Gas Pre-concentration, Pre-separation and Detection

Xu¹,

Qu²,

Chang³

et al. 2022

Acta Chimica Sinica

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Gas separation and detection technology is closely related to people's daily production and life. With the emergence of various detection equipment, it has made remarkable progress in recent decades. Gas sensing materials play an important role in the process of gas separation and detection. Compared with traditional gas sensing materials, metal-organic frameworks (MOFs), as a new type of porous materials, has ultra-large surface area, extremely high porosity, regular pore structure and adjustable pore size. These unique advantages make MOFs particularly suitable as promising candidates for the gas pre-concentration, pre-separation and detection, so as to realize the collection and enhancement of low concentration gas, the separation of complex gas mixtures, and the reliable detection of trace target gases. The detection ability and separation efficiency are greatly improved eventually. Therefore, MOFs are expected to surpass the traditional materials, and their application in gas separation and detection deserves the attention of both academia and industry. Keywords gas detection; metal-organic frameworks; gas preconcentrator; gas chromatographic column; gas sensor 1 引言人类对大自然中气味的探索由来已久, 最新的研究结果显示人的嗅觉系统可以分辨出超过一万亿种不同的气味组合 [1] . 而随着科学研究的快速发展以及检测技术的不断进步, 出现了大量可用于气体分析的新型装置, 使人们实现了从仅能对气味进行简单的定性区分到可以定量地检测出复杂气体混合物中各种组分含量的突破. 基于这些检测装置, 在过去的几十年里, 气体检测技术已经成为了与工业制造、农业生产、环境监测、医学诊断、食品安全以及法医鉴定等许多研究领域息息相关的重要研究方向 [2][3][4][5] .目前, 常见的气体分析系统中的核心部件包括气体预富集器、气相色谱柱和气体传感器 [4] . 其中, 气体预富集器内填充了具有很强的气体吸附能力的富集材料, 可以在一段时间内吸附大量的被测气体, 随后通过热脱附的方式在短时间内释放出这些气体分子, 从而将低浓度的目标气体浓缩至可被后续传感器检测到的浓度 [6][7][8] . 而气相色谱柱针对的是复杂的气体混合物, 利用混合气体中不同组分与色谱柱固定相之间相互作用力的差异, 实现各种气体的逐一分离 [9][10][11][12] . 气体传感器通过检测涂覆在其表面的敏感膜与气体分子发生相互作用后产生的光学、电学或其他材料固有性质的变化, 并将这些变化转换为可测量的电信号, 从而实现被测气体种类和浓度的检测 [13][14][15] . 近些年来, 随着微加工技术的突破, 出现了灵敏度高、体积小、功耗低的微型气体预富集器 (micro preconcentrator, μPC) [16][17][18] 、微型气相色谱柱 (micro gas chromatography, μGC) [19][20][21] 和微型气体传感器 [22][23] , 以及由它们构成的便携式气体检测系统 [24][25][26][27][28] . 这些小型化装置的出现, 使得气体检测过程不仅限于实

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Regulating metal–organic frameworks as stationary phases and absorbents for analytical separations

Abstract: Metal-organic frameworks (MOFs) are highly ordered framework systems composed of metal centers and organic linkers through coordination bonds. The diversity of metal elements and easily modified organic ligands, together with...

Cited by 18 publications

References 98 publications

Emerging Nanoporous Materials for Biomolecule Separation

Emerging Nanoporous Materials for Biomolecule Separation

Experimental methods in chemical engineering: Gas chromatography—GC

Application of Metal-Organic Frameworks in Gas Pre-concentration, Pre-separation and Detection

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