Exosome-mediated cellular crosstalk within the tumor microenvironment upon irradiation

He, Chuanshi; Li, Ling; Wang, Linlin; Meng, Wanrong; Hao, Yaying; Zhu, Guiquan

doi:10.20892/j.issn.2095-3941.2020.0150

Cited by 27 publications

(15 citation statements)

References 100 publications

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“…At present, there are not many reports on bystander effects and exosomes produced after high-LET irradiation [ 446 , 447 , 448 ]. Interestingly, Yu et al [ 449 ] and He et al [ 450 ] reported that in exosomes (nanovesicles) derived from the serum of prostate cancer patients after treatment with CIRT (C-ions LET: 33.7 keV/μm), 66 Gy equivalents in daily fractions of 2.75 Gy equivalents) nine specific miRNAs were identified among which expression levels of miR654-3p and miR-378-5p could be correlated with CIRT efficacy and thus could serve as biomarkers for antitumor treatment efficacy [ 449 , 450 ]. This suggests that such exosomes may well be involved in beneficial bystander/abscopal effects [ 451 ] and in anticancer RT [ 452 ].…”

Section: Ionizing Radiation (Ir) Effects Involving Mitochondriamentioning

confidence: 99%

Role of Mitochondria in Radiation Responses: Epigenetic, Metabolic, and Signaling Impacts

Averbeck

Rodriguez-Lafrasse

2021

IJMS

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Until recently, radiation effects have been considered to be mainly due to nuclear DNA damage and their management by repair mechanisms. However, molecular biology studies reveal that the outcomes of exposures to ionizing radiation (IR) highly depend on activation and regulation through other molecular components of organelles that determine cell survival and proliferation capacities. As typical epigenetic-regulated organelles and central power stations of cells, mitochondria play an important pivotal role in those responses. They direct cellular metabolism, energy supply and homeostasis as well as radiation-induced signaling, cell death, and immunological responses. This review is focused on how energy, dose and quality of IR affect mitochondria-dependent epigenetic and functional control at the cellular and tissue level. Low-dose radiation effects on mitochondria appear to be associated with epigenetic and non-targeted effects involved in genomic instability and adaptive responses, whereas high-dose radiation effects (>1 Gy) concern therapeutic effects of radiation and long-term outcomes involving mitochondria-mediated innate and adaptive immune responses. Both effects depend on radiation quality. For example, the increased efficacy of high linear energy transfer particle radiotherapy, e.g., C-ion radiotherapy, relies on the reduction of anastasis, enhanced mitochondria-mediated apoptosis and immunogenic (antitumor) responses.

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Section: Ionizing Radiation (Ir) Effects Involving Mitochondriamentioning

confidence: 99%

Role of Mitochondria in Radiation Responses: Epigenetic, Metabolic, and Signaling Impacts

Averbeck

Rodriguez-Lafrasse

2021

IJMS

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“…Exosome-related research has focused on the exosome’s ability to efficiently transfer an array of selected cargos to recipient cells ( 49 ). Studies about the function of exosomes in malignant tumors have developed substantially compared with studies in other fields, and increasing evidence supports exosome-mediated intercellular crosstalk in the TME ( 50 , 51 ). Accumulating evidence has revealed that exosomes are involved in many features of malignant tumors, including neoplasia, progression, metastasis, angiogenesis, and drug resistance ( 52 – 55 ).…”

Section: Roles Of Exosome In the Initiation And Development Of Esccmentioning

confidence: 99%

Small Extracellular Vesicles in the Development, Diagnosis, and Possible Therapeutic Application of Esophageal Squamous Cell Carcinoma

et al. 2021

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Esophageal squamous cell carcinoma (ESCC) persists among the most lethal and broad-spreading malignancies in China. The exosome is a kind of extracellular vesicle (EV) from about 30 to 200 nm in diameter, contributing to the transfer of specific functional molecules, such as metabolites, proteins, lipids, and nucleic acids. The paramount role of exosomes in the formation and development of ESCC, which relies on promoting intercellular communication in the tumor microenvironment (TME), is manifested with immense amounts. Tumor-derived exosomes (TDEs) participate in most hallmarks of ESCC, including tumorigenesis, invasion, angiogenesis, immunologic escape, metastasis, radioresistance, and chemoresistance. Published reports have delineated that exosome-encapsulated cargos like miRNAs may have utility in the diagnosis, as prognostic biomarkers, and in the treatment of ESCC. This review summarizes the function of exosomes in the neoplasia, progression, and metastasis of ESCC, which improves our understanding of the etiology and pathogenesis of ESCC, and presents a promising target for early diagnostics in ESCC. However, recent studies of exosomes in the treatment of ESCC are sparse. Thus, we introduce the advances in exosome-based methods and indicate the possible applications for ESCC therapy in the future.

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“…EVs are typically cup-shaped, negative-staining, and round-shaped under transmission and cryogenic electron microscopy [9] . According to size and biogenic process, EVs can be divided into three main subgroups: (i) exosomes (30–100 nm), (ii) microvesicles (20–1000 nm), and (iii) apoptotic bodies (50–5000 nm) [10] .…”

Section: Extracellular Vesicles (Evs)mentioning

confidence: 99%

Extracellular vesicle-orchestrated crosstalk between cancer-associated fibroblasts and tumors

Wang

et al. 2021

Translational Oncology

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Exosome-mediated cellular crosstalk within the tumor microenvironment upon irradiation

Cited by 27 publications

References 100 publications

Role of Mitochondria in Radiation Responses: Epigenetic, Metabolic, and Signaling Impacts

Role of Mitochondria in Radiation Responses: Epigenetic, Metabolic, and Signaling Impacts

Small Extracellular Vesicles in the Development, Diagnosis, and Possible Therapeutic Application of Esophageal Squamous Cell Carcinoma

Extracellular vesicle-orchestrated crosstalk between cancer-associated fibroblasts and tumors

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