Structural brain measures linked to clinical phenotypes in major depression replicate across clinical centres

Yu, Meichen; Cullen, Nicholas; Linn, Kristin A.; Oathes, Desmond J.; Seok, Darsol; Cook, Philip A.; Duprat, Romain; Aselcioglu, Irem; Moore, Tyler M.; Davatzikos, Christos; Oquendo, María A.; Weissman, Myrna M.; Shinohara, Russell T.; Sheline, Yvette I.

doi:10.1038/s41380-021-01039-8

Cited by 24 publications

(11 citation statements)

References 73 publications

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“…The precuneus is a key node of the posteromedial cortex, engaging in a wide range of functions, e.g., self-related processing, consciousness, episodic memory, and visuo-spatial imagery ( 30 ). The function and structure of precuneus have been proved to be implicated in the neuropathology ( 31 – 34 ) and treatment ( 35 ) of MD. Furthermore, precuneus is a central region of the default-mode network, whose impairments have been widely reported in depression ( 36 , 37 ).…”

Section: Discussionmentioning

confidence: 99%

The Function and Structure of Precuneus Is Associated With Subjective Sleep Quality in Major Depression

Zhang

2022

Front. Psychiatry

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BackgroundPoor sleep quality is related to depression. However, the investigation of the neural basis for poor sleep quality in individuals with major depression (MD) is limited.MethodsResting state functional and structural MRI data were derived from 114 MD individuals and 74 normal controls (NCs). Fractional amplitude of low-frequency fluctuation (fALFF) and gray matter volume (GMV) were used to measure function and structure of the brain. Pittsburgh Sleep Quality Index (PSQI) was performed to evaluate subjective sleep quality. Correlations were carried out to investigate links of PSQI score with brain imaging indices in MD and NCs, separately. We also examined the differences in fALFF and GMV of brain regions related to PSQI score between MD and NCs.ResultsIn contrast to NCs, MD individuals had higher PSQI score. The higher PSQI score was associated with lower fALFF and lower GMV in bilateral precuneus in MD individuals. Moreover, the MD individuals exhibited increased fALFF in bilateral precuneus compared with NCs. However, the correlation between subjective sleep quality and neuroimaging parameters was not significant in NCs.ConclusionThe implication of these findings is that the function and structure of precuneus provides a neural basis for subjective poor sleep quality in MD. Understanding this may lead to better intervention of depression and associated sleep complaints.

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Section: Discussionmentioning

confidence: 99%

The Function and Structure of Precuneus Is Associated With Subjective Sleep Quality in Major Depression

Zhang

2022

Front. Psychiatry

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“…This finding does not align with the “bigger is better” hypothesis, which suggests that better brain functions and behavioural performance are associated with bigger brain areas 37 , and vice versa. For instance, in adults, reductions in CT in associative areas have been associated with neurodegeneration in clinical samples 38 , 39 . Alternatively, this association has been related with healthy maturation of the brain cortex during adolescence 40 and during lifespan 41 .…”

Section: Discussionmentioning

confidence: 99%

A cross-cohort replicable and heritable latent dimension linking behaviour to multi-featured brain structure

et al. 2022

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Identifying associations between interindividual variability in brain structure and behaviour requires large cohorts, multivariate methods, out-of-sample validation and, ideally, out-of-cohort replication. Moreover, the influence of nature vs nurture on brain-behaviour associations should be analysed. We analysed associations between brain structure (grey matter volume, cortical thickness, and surface area) and behaviour (spanning cognition, emotion, and alertness) using regularized canonical correlation analysis and a machine learning framework that tests the generalisability and stability of such associations. The replicability of brain-behaviour associations was assessed in two large, independent cohorts. The load of genetic factors on these associations was analysed with heritability and genetic correlation. We found one heritable and replicable latent dimension linking cognitive-control/executive-functions and positive affect to brain structural variability in areas typically associated with higher cognitive functions, and with areas typically associated with sensorimotor functions. These results revealed a major axis of interindividual behavioural variability linking to a whole-brain structural pattern.

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“…The present study considered IDPs generated from the T1-weighted structural MRI and dMRI, which have been used to study depression. 46 , 47 , 48 To our knowledge, this is the first population-scale study to examine associations between depressive symptoms and brain IDPs while evaluating visual function. The association between PHQ-2 score and GMV in the supracalcarine cortex was detectable in the whole cohort.…”

Section: Discussionmentioning

confidence: 99%

Association of Visual Health With Depressive Symptoms and Brain Imaging Phenotypes Among Middle-Aged and Older Adults

et al. 2022

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ImportanceVision loss and depression are common conditions with major health implications. However, mechanisms of the association of visual health (across the full acuity spectrum) with depression remain unclear.ObjectiveTo characterize the association between visual health and depression and investigate the association between depression and brain microstructure and macrostructure in subgroups divided by visual acuity.Design, Setting, and ParticipantsIn the UK Biobank Study cohort, 114 583 volunteers were included at baseline from March to June 2006 to July 2010. Habitual distance visual acuity was examined using the logarithm of the minimum angle of resolution (LogMAR) characters. Depression was identified based on Patient Health Questionnaire (PHQ) or through an interview-based psychiatric diagnosis. Subgroup participants completed multimodal magnetic resonance imaging (MRI) of the brain and PHQ evaluation during the imaging visit after 2014. Data were analyzed from May 5 to August 9, 2022.Main Outcomes and MeasuresDepression, depressive symptoms, and imaging-derived phenotypes from T1-weighted and diffusion MRI.ResultsOf the 114 583 participants from the UK Biobank Study, 62 401 (54.5%) were women, and the mean (SD) age was 56.8 (8.1) years (range, 39-72 years). A 1-line worse visual acuity (0.1 LogMAR increase) was associated with 5% higher odds of depression (odds ratio, 1.05 [95% CI, 1.04-1.07]) after adjustment for age, sex, race and ethnicity, Townsend index, educational qualifications, smoking, alcohol consumption, obesity, physical activity, history of hypertension, diabetes, hyperlipidemia, and family history of depression. Of the 7844 participants eligible for MRI analysis, there were linear associations between PHQ score and the left volume of gray matter in supracalcarine cortex (coefficient, 7.61 [95% CI, 3.90-11.31]) and mean isotropic volume fraction (ISOVF) in the right fornix (cres) and/or stria terminalis (coefficient, 0.003 [95% CI, 0.001-0.004]) after correction for multiple comparison. In addition, their association could be moderated by visual acuity, whereby increased PHQ score was associated with higher ISOVF levels only among those with poorer visual acuity (P = .02 for interaction).Conclusions and RelevanceThis study suggests an association between visual health and depression and that the diffusion characteristic of ISOVF in the fornix (cres) and/or stria terminalis is associated with depressive symptoms in participants with poorer visual acuity.

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Structural brain measures linked to clinical phenotypes in major depression replicate across clinical centres

Cited by 24 publications

References 73 publications

The Function and Structure of Precuneus Is Associated With Subjective Sleep Quality in Major Depression

The Function and Structure of Precuneus Is Associated With Subjective Sleep Quality in Major Depression

A cross-cohort replicable and heritable latent dimension linking behaviour to multi-featured brain structure

Association of Visual Health With Depressive Symptoms and Brain Imaging Phenotypes Among Middle-Aged and Older Adults

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